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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Konje, Justin C. / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica


IMPACT FACTOR 2018: 1.361
5-year IMPACT FACTOR: 1.578

CiteScore 2018: 1.29

SCImago Journal Rank (SJR) 2018: 0.522
Source Normalized Impact per Paper (SNIP) 2018: 0.602

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1619-3997
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Volume 38, Issue 6

Issues

Comparative analysis of insulin-like growth factor binding protein-1 (IGFBP-1), placental alpha-microglobulin-1 (PAMG-1) and nitrazine test to diagnose premature rupture of membranes in pregnancy

Shephali Tagore
  • Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Kenneth Kwek
  • Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2010-08-13 | DOI: https://doi.org/10.1515/jpm.2010.099

Abstract

Purpose: To compare insulin-like growth factor binding protein-1 (IGFBP-1) (non-phosphorylated), placental alpha-microglobulin-1 (PAMG-1) and nitrazine test to diagnose premature rupture of membrane to allow gestation-specific management.

Methods: We recruited 100 women with signs or symptoms of premature rupture of membranes (PROM), between 17 and 37 weeks at a tertiary referral center.

Results: In 100 women in whom PAMG-1 was performed, sensitivity was 92.7%, specificity was 100%, positive predictive value (PPV) was 100% and negative predictive value (NPV) was 95.2%. IGFBP-1 was performed in 94 women, the sensitivity was 87.5%, specificity was 94.4%, PPV was 92.1% and NPV was 91.1%. In 98 women in whom nitrazine test was performed, the sensitivity was 85%, specificity was 39.7%, PPV was 49.3% and NPV was 79.3%.

Conclusion: PAMG-1 was the most accurate test in diagnosing rupture of membranes and had the highest sensitivity, specificity, PPVs and NPVs.

Keywords: Insulin-like growth factor binding protein-1 (non-phosphorylated); placental alpha-microglobulin-1; premature rupture of membranes

About the article

Corresponding author: Dr. Shephali Tagore MBBS, DRCOG, MD, MRCOG Department of Maternal Fetal Medicine KK Women's and Children's Hospital 100 Bukit Timah Road Singapore 229899 Tel.: +65 81211676 Fax: +65 63941017


Received: 2010-03-01

Revised: 2010-05-19

Accepted: 2010-05-21

Published Online: 2010-08-13

Published Online: 2010-08-13

Published in Print: 2010-11-01


Citation Information: Journal of Perinatal Medicine, Volume 38, Issue 6, Pages 609–612, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm.2010.099.

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