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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Milner, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

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Online
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1619-3997
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In This Section
Volume 39, Issue 3 (May 2011)

Issues

Amniotic lamellar body counts can predict the occurrence of respiratory distress syndrome as well as transient tachypnea of the newborn (TTN)

Hiroyuki Tsuda
  • Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Nagoya, Japan
  • Department of Fetal and Maternal Medicine, Nagara Medical Center, Gifu City, Japan
  • Email:
/ Yuichiro Takahashi
  • Department of Fetal and Maternal Medicine, Nagara Medical Center, Gifu City, Japan
/ Shigenori Iwagaki
  • Department of Fetal and Maternal Medicine, Nagara Medical Center, Gifu City, Japan
/ Yasushi Uchida
  • Department of Pediatrics, Nagara Medical Center, Gifu City, Japan
/ Ichiro Kawabata
  • Department of Fetal and Maternal Medicine, Nagara Medical Center, Gifu City, Japan
/ Masahiro Hayakawa
  • Department of Pediatrics, Nagoya University School of Medicine, Nagoya, Japan
/ Seiji Sumigama
  • Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Nagoya, Japan
/ Hiromi Hayakawa
  • Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Nagoya, Japan
/ Tomomi Kotani
  • Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Nagoya, Japan
/ Fumitaka Kikkawa
  • Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Nagoya, Japan
Published Online: 2011-02-11 | DOI: https://doi.org/10.1515/jpm.2011.006

Abstract

Aims: The purpose of this study is to predict the occurrence of transient tachypnea of the newborn (TTN) using amniotic lamellar body count (LBC) and compare the LBCs in neonates with TTN with the LBCs in neonates with respiratory distress syndrome (RDS) and controls.

Methods: Three hundred and eighty-one amniotic fluid samples were obtained at cesarean section from 27 to 40 weeks of gestation. Samples were analyzed immediately without centrifugation and the number of lamellar bodies was counted.

Results: The LBC in amniotic fluid ranged from 1,000 to 577,000/μL. An LBC cut-off value of 48,500/μL resulted in 84.7% sensitivity, 76.2% specificity, and 98.1% negative predictive value for predicting TTN. The LBC in neonates with TTN was significantly lower than that in controls (50,000 vs. 122,000; P<0.001) and significantly higher than that in neonates with RDS (50,000 vs. 21,000; P=0.042).

Conclusions: We established a cut-off value of LBC for predicting the occurrence of TTN. The LBC in neonates with TTN was significantly lower than that in controls. Amniotic LBC can be a useful marker to predict if neonatal respiratory management is required.

Keywords: Amniotic fluid; cesarean section; lamellar body; respiratory distress syndrome; transient tachypnea of the newborn

About the article

Corresponding author: Hiroyuki Tsuda, MD Department of Obstetrics and Gynecology Nagoya University School of Medicine 65 Tsurumai-cho Showa-ku Nagoya 466-8550 Japan Tel./Fax: +81-52-744-2261


Received: 2010-07-19

Revised: 2010-10-02

Accepted: 2010-10-21

Published Online: 2011-02-11

Published Online: 2011-02-11

Published in Print: 2011-05-01



Citation Information: Journal of Perinatal Medicine, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm.2011.006. Export Citation

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[1]
Hiroyuki Tsuda, Akihiro Hirakawa, Tomomi Kotani, Seiji Sumigama, Yukio Mano, Tomoko Nakano, Kenji Imai, Ichiro Kawabata, Yuichiro Takahashi, Shigenori Iwagaki, and Fumitaka Kikkawa
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[2]
C. Kart, S. Guven, E. S. Guvendag Guven, D. Armangil, and A. Mentese
Journal of Obstetrics & Gynaecology, 2014, Page 1
[3]
Hiroyuki Tsuda, Tomomi Kotani, Seiji Sumigama, Yukio Mano, Li Hua, and Fumitaka Kikkawa
Journal of Maternal-Fetal and Neonatal Medicine, 2014, Page 1
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Hiroyuki Tsuda, Tomomi Kotani, Seiji Sumigama, Yukio Mano, Li Hua, Hiromi Hayakawa, Masahiro Hayakawa, Yoshiaki Sato, and Fumitaka Kikkawa
Early Human Development, 2014, Volume 90, Number 1, Page 51

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