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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Milner, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

9 Issues per year

IMPACT FACTOR 2016: 1.577
5-year IMPACT FACTOR: 1.705

CiteScore 2016: 1.49

SCImago Journal Rank (SJR) 2016: 0.602
Source Normalized Impact per Paper (SNIP) 2016: 0.832

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Volume 39, Issue 3 (May 2011)


Does prenatal antibiotic therapy compromise the diagnosis of early-onset infection and management of the neonate?

Agnieszka Kordek
  • Department of Neonatal Diseases, Pomeranian Medical University, Szczecin, Poland
/ Andrzej Torbé
  • Department of Obstetrics and Gynecology, Pomeranian Medical University, Szczecin, Poland
  • Email:
/ Wojciech Podraza
  • Chair and Department of Medical Physics, Pomeranian Medical University, Szczecin, Poland
/ Beata Łoniewska
  • Department of Neonatal Diseases, Pomeranian Medical University, Szczecin, Poland
/ Joanna Jursa-Kulesza
  • Chair and Department of Microbiology and Immunology, Pomeranian Medical University, Szczecin, Poland
/ Jacek Rudnicki
  • Department of Neonatal Diseases, Pomeranian Medical University, Szczecin, Poland
Published Online: 2011-05-03 | DOI: https://doi.org/10.1515/jpm.2011.031


Aim: To assess the impact of prenatal antibiotic treatment on procalcitonin (PCT) and C-reactive protein (CRP) concentrations in cord blood, and on the rate of positive neonatal blood cultures.

Methods: Neonates with early-onset infection (Group A; n=46) were compared with healthy controls (Group B; n=240). We evaluated the relationship between prenatal antibiotic therapy and early-onset infection, and for interactions with antibiotic therapy in the neonate immediately after birth.

Results: In the Group A antibiotics were administered significantly more often prenatally and more often to neonates just after birth. The percentage of negative blood cultures in infected neonates was higher when antibiotic treatment was instituted prenatally. Differences in cord blood PCT and CRP concentrations were significant between both groups and were independent of prenatal antibiotic treatment. Streptococcus agalactiae was the most frequent species.

Conclusions: Almost one-third of neonates present with early-onset infection in spite of prenatal antibiotic therapy. Cord blood PCT and CRP measurements may be helpful in the diagnosis of infection also in cases when antibiotic therapy was started prenatally. Prenatal antibiotic administration reduced the number of positive blood cultures in neonates with early-onset infection and was associated with a greater rate of antibiotic treatment after birth in neonates without infection.

Keywords: Blood cultures; C-reactive protein; inborn infection; prenatal antibiotic therapy; procalcitonin

About the article

Corresponding author: Prof. Andrzej Torbé Department of Obstetrics and Gynecology Pomeranian Medical University Al. Powstańców Wielkopolskich 72 70-111 Szczecin Poland Tel./Fax: +48 91 4661350

Received: 2010-05-25

Revised: 2011-01-10

Accepted: 2011-01-24

Published Online: 2011-05-03

Published Online: 2011-05-03

Published in Print: 2011-05-01

Citation Information: Journal of Perinatal Medicine, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm.2011.031.

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