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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Milner, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Ogata, Edward / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

9 Issues per year

IMPACT FACTOR increased in 2015: 1.798
Rank 46 out of 120 in category Pediatrics in the 2015 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 0.731
Source Normalized Impact per Paper (SNIP) 2014: 0.687
Impact per Publication (IPP) 2014: 1.483

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Historical notes on immaturity. Part 2: Surviving against the odds

Michael Obladen
  • Department of Neonatology, Charité University Medicine, Berlin, Germany
  • :
Published Online: 2011-07-05 | DOI: https://doi.org/10.1515/jpm.2011.057


Survivors of immaturity of outstanding intelligence include Fortunio Licetus, born in 1577, and Isaac Newton, born in 1643. Reliable descriptions began appearing around 1820, and over a dozen infants were born weighing under 1000 g and before World War II, who developed normally. From 1876 to 2006, the birth weight at which half of the infants survived dropped from 2200 to 600 g. Statistics depended on how abortion, stillbirth and live birth were defined, which differed greatly from country to country. WHO definitions in 1993 required the registration of all infants weighing 500 g (22 complete weeks) or above. This definition was not universally adopted, resulting in considerable underreporting. Many medical societies issued ethical recommendations concerning the obligatory or optional treatment of immature infants. The “window”, at which treatment is optional has been set at 22–23 weeks (Japan, Germany), 23–24 weeks (UK, USA, Canada), or 24–26 weeks (France, Netherlands, Switzerland). Instead of assessing an infant's individual prognosis, and ignoring its gender, co-morbidities, and particular cause of premature delivery, these rules frequently relied on gestational age alone to initiate or withhold life support.

Keywords: Border of viability; extremely low birthweight; history; immaturity; infant; mortality; newborn

Corresponding author: Prof. Dr. Michael Obladen Department of Neonatology Charité University Medicine Berlin Augustenburger Platz 1 13353 Berlin Germany Tel.: +49 30 (0)30 450566122 Fax: +49 30 (0)30 450566922

Received: 2010-11-26

Revised: 2011-02-24

Accepted: 2011-03-15

Published Online: 2011-07-05

Published Online: 2011-07-05

Published in Print: 2011-09-01

Citation Information: Journal of Perinatal Medicine. Volume 39, Issue 5, Pages 571–577, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm.2011.057, July 2011

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