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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Konje, Justin C. / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica


IMPACT FACTOR 2018: 1.361
5-year IMPACT FACTOR: 1.578

CiteScore 2018: 1.29

SCImago Journal Rank (SJR) 2018: 0.522
Source Normalized Impact per Paper (SNIP) 2018: 0.602

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1619-3997
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Volume 40, Issue 3

Issues

Maternal and fetal cord blood lipids in intrauterine growth restriction

Ulrich Pecks / Meike Brieger
  • Department of Obstetrics and Gynecology of the University Hospital of the RWTH Aachen, Germany
  • Other articles by this author:
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/ Barbara Schiessl
  • Department of Obstetrics and Gynecology of the University Hospital of the RWTH Aachen, Germany
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  • De Gruyter OnlineGoogle Scholar
/ Dirk O. Bauerschlag
  • Department of Obstetrics and Gynecology of the University Hospital of the RWTH Aachen, Germany
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  • De Gruyter OnlineGoogle Scholar
/ Daniela Piroth
  • Department of Obstetrics and Gynecology of the University Hospital of the RWTH Aachen, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Benjamin Bruno
  • Department of Obstetrics and Gynecology of the University Hospital of the RWTH Aachen, Germany
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  • De Gruyter OnlineGoogle Scholar
/ Christina Fitzner / Thorsten Orlikowsky / Nicolai Maass
  • Department of Obstetrics and Gynecology of the University Hospital of the RWTH Aachen, Germany
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/ Werner Rath
  • Department of Obstetrics and Gynecology of the University Hospital of the RWTH Aachen, Germany
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Published Online: 2012-01-06 | DOI: https://doi.org/10.1515/jpm.2011.135

Abstract

Aim: Small for gestational age neonates (SGA) could be subdivided into two groups according to the underlying causes leading to low birth weight. Intrauterine growth restriction (IUGR) is a pathologic condition with diminished growth velocity and fetal compromised well-being, while non-growth restricted SGA neonates are constitutionally (genetically determined) small. Antenatal sonographic measurements are used to differentiate these two subgroups. Maternal metabolic changes contribute to the pathogenesis of IUGR. A disturbed lipid metabolism and cholesterol supply might affect the fetus, with consequences for fetal programming of cardiovascular diseases. We evaluated fetal serum lipids and hypothesized a more atherogenic lipoprotein profile in IUGR fetuses.

Methods: Umbilical cord serum lipids and oxidative modified, low-density lipoprotein (oxLDL) concentrations were measured by colorimetric enzymatic measurements, or by ELISA. Values of IUGR (n=36) and constitutionally small for gestational age neonates (SGA, n=22) were compared with those of healthy, adequate for gestational age, born neonates (CN, n=97). SAS-statistic software was used and two-way ANOVA was adjusted for gestational age at delivery.

Results: Fetal high-density lipoprotein cholesterol (HDL-C) and total cholesterol (TC) concentrations were found to be lower in the IUGR compared to the CN and SGA groups (HDL-C: P<0.001, TC: P<0.01). Atherogenic indices, including the oxLDL/LDL-C ratio, were increased in the IUGR compared to the CN group (oxLDL/LDL-C ratio: P<0.001).

Conclusion: Our results support the hypothesis of a disturbed cholesterol supply in IUGR fetuses. Born SGA has been shown to be a risk factor for developing cardiovascular disease later in life. Since HDL-C has anti-inflammatory properties, a reduced HDL-C during fetal development, and an increase in atherogenic indices, might provide a link to this observation in IUGR fetuses.

Keywords: Atherogenic index; cholesterol; IUGR; oxLDL; prematurity

About the article

Corresponding author: Ulrich Pecks, MD Department of Obstetrics and Gynecology University Hospital of the RWTH Aachen Pauwelsstraße 30 52074 Aachen Germany Tel.: +49 241 80 36065 Fax: +49 241 80 82476


Received: 2011-08-08

Revised: 2011-11-15

Accepted: 2011-11-21

Published Online: 2012-01-06

Published in Print: 2012-04-01


Citation Information: Journal of Perinatal Medicine, Volume 40, Issue 3, Pages 287–296, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm.2011.135.

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