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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Konje, Justin C. / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica

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Volume 41, Issue 5


The correlation of ultrasonographic placental architecture with placental histology in the low-risk primigravid population

Sharon M. Cooley / Jennifer C. Donnelly / Thomas Walsh / Corrina McMahon / John Gillan / Michael P. Geary
Published Online: 2013-03-21 | DOI: https://doi.org/10.1515/jpm-2013-0015


Aim: To determine the association, if any, between placental architecture findings assessed ultrasonographically at 22 and 36 weeks and placental histology.

Methods: There was prospective recruitment of 1011 low-risk primigravids from the antenatal clinic at the Rotunda Hospital, Dublin, Ireland. Ultrasound of the placenta was performed at 22 and 36 weeks and histological assessment was made of the placenta of all participants.

Results: Complete data pertaining to ultrasound and placental histology was available for 810 women (80%). Placental calcification on ultrasound in the third trimester was associated with a higher incidence of placental infarction identified following placental histology (80.0% vs. 21.5%; P=0.009: r=0.115). The placental thickness on ultrasound in the second trimester was less in cases complicated by chorioamnionitis (2.62 cm vs. 3.07 cm; P=0.039: r=–0.176). Chronic villitis was associated with a statistically significant increased incidence of antenatal placental infarction identified on ultrasound in the third trimester (10.7% vs. 1.9%; P=0.020: r=0.113). Intervillous thrombi occurred more frequently in cases with reduced placental thickness on ultrasound in the second trimester (3.0 cm vs. 3.3 cm; P=0.035: r=–0.171).

Conclusions: Antenatal ultrasound of the placenta may aid detection of placental disease, particularly in the identification of placental infarction.

Keywords: Calcification; histology; infarction; placental architecture; ultrasound


  • [1]

    Becroft DM, Thompson JM, Mitchell EA. Placental infarcts, intervillous fibrin plaques, and intervillous thrombi: incidences, cooccurrences, and epidemiological associations. Pediatr Dev Pathol. 2004;7:26–34.PubMedGoogle Scholar

  • [2]

    Cooley SM, Donnelly JC, Walsh T, McMahon C, Gillan J, Geary MP. The impact of ultrasonographic placental architecture on antenatal course, labor and delivery in a low-risk primigravid population. J Matern Fetal Neonatal Med. 2011;24:493–7.Web of ScienceGoogle Scholar

  • [3]

    Cooley SM, Reidy FR, Mooney EE, McAuliffe FM. Antenatal suspicion of ischemic placental disease and coexistence of maternal and fetal placental disease: analysis of over 500 cases. Am J Obstet Gynecol. 2011;205:576.e1–6.Web of ScienceGoogle Scholar

  • [4]

    Drooger JC, Troe JW, Borsboom GJ, Hofman A, Mackenbach JP, Moll HA, et al. Ethnic differences in prenatal growth and the association with maternal and fetal characteristics. Ultrasound Obstet Gynecol. 2005;26:115–22.PubMedCrossrefGoogle Scholar

  • [5]

    Feeley L, Mooney EE. Villitis of unknown aetiology: correlation of recurrence with clinical outcome. J Obstet Gynaecol. 2010;30:476–9.Web of SciencePubMedCrossrefGoogle Scholar

  • [6]

    Fox H. Pathology of the placenta. Clin Obstet Gynecol. 1986;13:501–19.Google Scholar

  • [7]

    Fox H. The pathology of the placenta. 2nd ed. Philadelphia, PA: WB Saunders; 1997.Google Scholar

  • [8]

    Gersell DJ. Chronic villitis, chronic chorioamnionitis, and maternal floor infarction. Semin Diagn Pathol. 1993;10:251–66.PubMedGoogle Scholar

  • [9]

    Grannum P, Berkowitz RL, Hobbins JC. The ultrasonic changes in the maturing placenta and their relationship to fetal pulmonic maturity. Am J Obstet Gynecol. 1979;133:915–22.Google Scholar

  • [10]

    Jauniaux E, Campbell S. Ultrasonographic assessment of placental abnormalities. Am J Obstet Gynecol. 1990;163:1650–8.PubMedCrossrefGoogle Scholar

  • [11]

    Kraus FT, Redline R, Gersell DJ, editors. AFIP. Atlas of nontumor pathology: placental pathology. Washington, DC: American Registry of Pathology; 2004.Google Scholar

  • [12]

    Linduska N, Dekan S, Messerschmidt A, Kasprian G, Brugger PC, Chalubinski K. Placental pathologies in fetal MRI with pathohistological correlation. Placenta. 2009;30:555–9.PubMedWeb of ScienceCrossrefGoogle Scholar

  • [13]

    Newton ER. Chorioamnionitis and intraamniotic infection. Clin Obstet Gynecol. 1993;36:795–808.CrossrefPubMedGoogle Scholar

  • [14]

    Redline RW. Recurrent villitis of bacterial etiology. Pediatr Pathol Lab Med. 1996;16:995–1001.PubMedGoogle Scholar

  • [15]

    Redline RW. Placental pathology: a systematic approach with clinical correlations. Placenta. 2008;29(Suppl A):S86–91.Web of ScienceCrossrefGoogle Scholar

  • [16]

    Redline RW, Boyd T, Campbell V, Hyde S, Kaplan C, Khong TY, et al. Maternal vascular underperfusion: nosology and reproducibility of placental reaction patterns. Pediatr Dev Pathol. 2004;7:237–49.PubMedGoogle Scholar

  • [17]

    Rodriguez JG, Porter HJ, Andrews HS, Soothill PW. Placental lesions: is growth a predictor of bad outcome? Fetal Diagn Ther. 1997;12:163–6.PubMedCrossrefGoogle Scholar

  • [18]

    Salafia CM, Yampolsky M, Misra DP, Shlakhter O, Haas D, Eucker B, et al. Placental surface shape, function, and effects of maternal and fetal vascular pathology. Placenta. 2010;31:958–62.PubMedWeb of ScienceCrossrefGoogle Scholar

  • [19]

    Sepulveda W, Rojas I, Robert JA, Schnapp C, Alcalde JL. Prenatal detection of velamentous insertion of the umbilical cord: a prospective color Doppler ultrasound study. Ultrasound Obstet Gynecol. 2003;21:564–9.PubMedCrossrefGoogle Scholar

  • [20]

    Severi FM, Bocchi C, Visentin A, Falco P, Cobellis L, Florio P, et al. Uterine and fetal cerebral Doppler predict the outcome of third-trimester small-for-gestational age fetuses with normal umbilical artery. Doppler. Ultrasound Obstet Gynecol. 2002;19:225–8.PubMedCrossrefGoogle Scholar

  • [21]

    Torrance HL, Bloemen MC, Mulder EJ, Nikkels PG, Derks JB, de Vries LS, et al. Predictors of outcome at 2 years of age after early intrauterine growth restriction. Ultrasound Obstet Gynecol. 2010;36:171–7.Google Scholar

  • [22]

    Vedmedovska N, Rezeberga D, Teibe U, Melderis I, Donders GG. Placental pathology in fetal growth restriction. Eur J Obstet Gynecol Reprod Biol. 2011;155:36–40.PubMedCrossrefGoogle Scholar

  • [23]

    Yampolsky M, Salafia CM, Shlakhter O, Haas D, Eucker B, Thorp J. Centrality of the umbilical cord insertion in a human placenta influences the placental efficiency. Placenta. 2009;30:1058–64.Web of ScienceCrossrefGoogle Scholar

About the article

Corresponding author: Sharon M. Cooley, Rotunda Hospital, Dublin, Ireland, Tel.: +353-876380889, Fax: +353-18726572

Received: 2013-01-22

Accepted: 2013-02-25

Published Online: 2013-03-21

Published in Print: 2013-09-01

Citation Information: Journal of Perinatal Medicine, Volume 41, Issue 5, Pages 505–509, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm-2013-0015.

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