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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

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In This Section
Volume 42, Issue 1 (Jan 2014)


Does the presence of thyroid antibodies affect the course and outcome of pregnancy in type 1 diabetic women?

Vasiliki Sarantopoulou
  • First Endocrine Section, Diabetes Centre, Alexandra Hospital, Athens, Greece
/ Vasiliki Vasileiou
  • First Endocrine Section, Diabetes Centre, Alexandra Hospital, Athens, Greece
/ Leda Sarika
  • First Endocrine Section, Diabetes Centre, Alexandra Hospital, Athens, Greece
/ George Philippou
  • First Endocrine Section, Diabetes Centre, Alexandra Hospital, Athens, Greece
/ Maria Alevizaki
  • Endocrine Unit, Department of Clinical Therapeutics, School of Medicine, Athens University, Athens, Greece
/ Aris Antsaklis
  • First Department of Obstertrics and Gynecology, University of Athens, Athens, Greece
/ Eleni Anastasiou
  • Corresponding author
  • First Endocrine Section, Diabetes Centre, Alexandra Hospital, Athens, Greece
  • Email:
Published Online: 2013-08-29 | DOI: https://doi.org/10.1515/jpm-2012-0273


Objective: The aim of the study was to evaluate the significance of the presence of thyroid peroxidase autoantibodies (anti-TPO Abs) in type 1 diabetes mellitus (DM1) pregnant women relative to the course of pregnancy and, especially, with regard to metabolic control, thyroid function, maternal complications and neonatal outcome.

Methods: In a prospective observational study of 91 DM1 women with singleton pregnancies, anti-TPO, anti-thyroglobulin, thyroid-stimulating hormone (TSH), and free thyroxine index (T4/thyroid binding capacity) were measured in each trimester. At each visit, HbA1c, body mass index, and units of insulin per kilogram were recorded, as were complications and pregnancy outcome.

Results: Twenty-one (27%) of the 78 women who met the inclusion criteria presented with positive anti-TPO Abs. There were no differences regarding glycemic control (HbA1c) or insulin dose. First-trimester TSH levels were significantly higher in the anti-TPO-positive group than in the anti-TPO-negative group. Finally, no differences were observed regarding diabetic or obstetric complications and neonatal outcome.

Conclusion: One fourth of DM1 pregnant women presented with positive anti-TPO Abs. However, the presence of anti-TPO Abs does not seem to be related with worse metabolic control or adverse pregnancy outcome. Further investigation is needed; meanwhile, the effort for early treatment of thyroid dysfunction and strict metabolic control in all DM1 women should be continued.

Keywords: Diabetes type 1; metabolic control; thyroid antibodies; TSH


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About the article

Corresponding author: Eleni Anastasiou, First Endocrine Section, Diabetes Centre, Alexandra Hospital, 80 Vas. Sofias St, Athens 11528, Greece, E-mail:

Received: 2012-11-21

Accepted: 2013-07-15

Published Online: 2013-08-29

Published in Print: 2014-01-01

Citation Information: Journal of Perinatal Medicine, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm-2012-0273. Export Citation

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