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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Milner, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

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In This Section
Volume 42, Issue 1 (Jan 2014)

Issues

Resuscitation at birth in neonates with meningomyelocele

Simone Aparecida Basso da Silva
  • Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, SP, Brazil
/ Maria Fernanda Branco de Almeida
  • Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, SP, Brazil
/ Antonio Fernandes Moron
  • Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, SP, Brazil
/ Sérgio Cavalheiro
  • Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, SP, Brazil
/ Patrícia Alessandra Dastoli
  • Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, SP, Brazil
/ Ruth Guinsburg
  • Corresponding author
  • Email:
Published Online: 2013-08-29 | DOI: https://doi.org/10.1515/jpm-2013-0021

Abstract

Aims: Compare the need for neonatal resuscitation procedures between newborn infants with and without meningomyelocele (MMC).

Results: This retrospective case-control study included 94 neonates with MMC, defined as open spinal dysraphism with exposure of nervous tissue, and 94 controls without malformations, paired with MMC infants by gender, mode of delivery, gestational age and time of birth. Infants were born at a university hospital in São Paulo, Brazil, from 2001 to 2010. After adjusting for perinatal variables (prenatal care, maternal hypertension, birth during the day shift, cephalic presentation, meconium in the amniotic fluid, gestational age <37 weeks and small-for-gestational-age infants), MMC increased the chance of positive pressure ventilation at birth [odds ratio (OR) 4.55 95% confidence interval (CI) 1.82–11.41], intubation at birth (OR 3.94 95% CI 1.14–13.59) and 1-min Apgar score 95% CI 0.99–7.57).

Conclusion: MMC is an independent factor associated with the need for positive pressure ventilation and intubation at birth.

Keywords: Cardiopulmonary resuscitation; infant; meningomyelocele; newborn

References

  • [1]

    Adzick NS. Fetal myelomeningocele: natural history, pathophysiology, and in-utero intervention. Semin Fetal Neonatal Med. 2010;15:9–14. [Web of Science]

  • [2]

    Adzick NS, Thom EA, Spong CY, Brock JW III, Burrows PK, Johnson MP, et al. A randomized trial of prenatal versus postnatal repair of myelomeningocele. N Engl J Med. 2011;364:993–1004. [Web of Science]

  • [3]

    Alexander GR, Kogan MD, Himes JH. 1994–1996 U.S. singleton birth weight percentiles for gestational age by race, Hispanic origin, and gender. Matern Child Health J. 1999;3:225–31.

  • [4]

    Ballard JL, Khoury JC, Wedig K, Wang L, Eilers-Walsman BL, Lipp R. New Ballard Score, expanded to include extremely premature infants. J Pediatr. 1991;119:417–23.

  • [5]

    Bowman RM, Boshnjaku V, McLone DG. The changing incidence of myelomeningocele and its impact on pediatric neurosurgery: a review from the Children’s Memorial Hospital. Childs Nerv Syst. 2009;25:801–6. [Crossref] [Web of Science]

  • [6]

    Castilla EE, Orioli IM, Lopez-Camelo JS, Dutra Mda G, Nazer-Herrera J. Latin American Collaborative Study of Congenital Malformations (ECLAMC). Preliminary data on changes in neural tube defect prevalence rates after folic acid fortification in South America. Am J Med Genet A. 2003;123A:123–8. [PubMed]

  • [7]

    Cuppen I, Eggink AJ, Lotgering FK, Rotteveel JJ, Mullaart RA, Roeleveld N. Influence of birth mode on early neurological outcome in infants with myelomeningocele. Eur J Obstet Gynecol Reprod Biol. 2011;156:18–22. [Web of Science]

  • [8]

    Danzer E, Finkel RS, Rintoul NE, Bebbington MW, Schwartz ES, Zarnow DM, et al. Reversal of hindbrain herniation after maternal-fetal surgery for myelomeningocele subsequently impacts on brain stem function. Neuropediatrics. 2008;39:359–62. [Web of Science]

  • [9]

    de Almeida MF, Guinsburg R, da Costa JO, Anchieta LM, Freire LM, Campos D Jr. Non-urgent caesarean delivery increases the need for ventilation at birth in term newborn infants. Arch Dis Child Fetal Neonatal Ed. 2010;95:F326–30. [Web of Science]

  • [10]

    de Almeida MF, Guinsburg R, da Costa JO, Anchieta LM, Freire LM, Junior DC. Resuscitative procedures at birth in late preterm infants. J Perinatol. 2007;27:761–5. [Crossref]

  • [11]

    Doctor BA, O’Riordan MA, Kirchner HL, Shah D, Hack M. Perinatal correlates and neonatal outcomes of small for gestational age infants born at term gestation. Am J Obstet Gynecol. 2001;185:652–9.

  • [12]

    Dolk H, De Wals P, Gillerot Y, Lechat MF, Ayme S, Cornel M, et al. Heterogeneity of neural tube defects in Europe: the significance of site of defect and presence of other major anomalies in relation to geographic differences in prevalence. Teratology. 1991;44:547–59. [Crossref] [PubMed]

  • [13]

    Guha-Ray DK. Open spina bifida (OSB) and intrapartum fetal distress. J Reprod Med. 1977;19:277–9.

  • [14]

    Holinger PC, Holinger LD, Reichert TJ, Holinger PH. Respiratory obstruction and apnea in infants with bilateral abductor vocal cord paralysis, meningomyelocele, hydrocephalus, and Arnold-Chiari malformation. J Pediatr. 1978;92:368–73.

  • [15]

    Kattwinkel J. Textbook of neonatal resuscitation. 4th ed. Elk Grove Village, IL: American Academy of Pediatrics/American Heart Association; 2000.

  • [16]

    Leone TA, Rich W, Finer NN. Neonatal intubation: success of pediatric trainees. J Pediatr. 2005;146:638–41.

  • [17]

    Nascimento LF. Prevalência de defeitos de fechamento de tubo neural no Vale do Paraíba, São Paulo. Rev Paul Pediatr. 2008;26:372–7. [Crossref]

  • [18]

    Nishimura T, Mori K, Sada Y, Fujii M. Apneic spells in a patient with myelomeningocele without Chiari type II malformation—case report. Neurol Med Chir (Tokyo). 1995;35:876–81.

  • [19]

    Ogata AJN, Camano L, Brunoni D. Perinatal factors associated with neural tube defects (anencephaly, spina bifida and encephalocele). Rev Paul Med. 1992;110:147–51.

  • [20]

    Patel RM, Jain L. Delivery after previous cesarean: short-term perinatal outcomes. Semin Perinatol. 2010;34:272–80. [Crossref] [PubMed] [Web of Science]

  • [21]

    Perlman JM, Risser R. Cardiopulmonary resuscitation in the delivery room. Associated clinical events. Arch Pediatr Adolesc Med. 1995;149:20–5.

  • [22]

    Rosenberg A. The IUGR newborn. Semin Perinatol. 2008;32:219–24. [Web of Science] [Crossref] [PubMed]

  • [23]

    Sakala EP, Andree I. Optimal route of delivery for meningomyelocele. Obstet Gynecol Surv. 1990;45:209–12. [PubMed] [Crossref]

  • [24]

    Schilleman K, van der Pot CJ, Hooper SB, Lopriore E, Walther FJ, te Pas AB. Evaluating manual inflations and breathing during mask ventilation in preterm infants at birth. J Pediatr. 2013;162:457–63. [Web of Science]

  • [25]

    Stark G, Drummond M. Spina bifida as an obstetric problem. Dev Med Child Neurol Suppl. 1970;22:157. [PubMed]

  • [26]

    Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, Walsh MC, et al. Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics. 2010;126:443–56.

  • [27]

    The International Liaison Committee on Resuscitation. The International Liaison Committee on Resuscitation (ILCOR) — consensus on science with treatment recommendations for pediatric and neonatal patients: neonatal resuscitation. Pediatrics. 2006;117:e978–88.

  • [28]

    Tomita T, McLone DG. Acute respiratory arrest. A complication of malformation of the shunt in children with myelomeningocele and Arnold-Chiari malformation. Am J Dis Child. 1983;137:142–4.

  • [29]

    Tulipan N, Sutton LN, Bruner JP, Cohen BM, Johnson M, Adzick NS. The effect of intrauterine myelomeningocele repair on the incidence of shunt-dependent hydrocephalus. Pediatr Neurosurg. 2003;38:27–33. [PubMed] [Crossref]

  • [30]

    Wu YW, Pham TN, Danielsen B, Towner D, Smith L, Johnston SC. Nighttime delivery and risk of neonatal encephalopathy. Am J Obstet Gynecol. 2011;204:37.e1–6.

About the article

Corresponding author: Ruth Guinsburg, Rua Vicente Felix 77 apt 09, São Paulo, SP 01410-020, Brazil, Tel.: +55 11 5584 0535, E-mail:


Received: 2013-01-27

Accepted: 2013-07-22

Published Online: 2013-08-29

Published in Print: 2014-01-01



Citation Information: Journal of Perinatal Medicine, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm-2013-0021. Export Citation

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