Jump to ContentJump to Main Navigation
Show Summary Details

Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Milner, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Ogata, Edward / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

9 Issues per year

IMPACT FACTOR increased in 2015: 1.798
Rank 46 out of 120 in category Pediatrics in the 2015 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 0.731
Source Normalized Impact per Paper (SNIP) 2014: 0.687
Impact per Publication (IPP) 2014: 1.483

See all formats and pricing


Select Volume and Issue


The importance of repeated measurements of the sFlt-1/PlGF ratio for the prediction of preeclampsia and intrauterine growth restriction

Katharina Schoofs
  • Department of Obstetrics, Charité University Medicine, Berlin, Germany
/ Ulrike Grittner
  • Department for Biostatistics and Clinical Epidemiology, Charité University Medicine, Berlin, Germany
/ Theresa Engels
  • Department of Obstetrics, Charité University Medicine, Berlin, Germany
/ Juliane Pape
  • Department of Gynecology and Obstetrics, DRK Berlin Westend, Berlin, Germany
/ Barbara Denk
  • Roche Professional Diagnostics, Penzberg, Germany
/ Wolfgang Henrich
  • Department of Obstetrics, Charité University Medicine, Berlin, Germany
/ Stefan Verlohren
  • Department of Obstetrics, Charité University Medicine, Berlin, Germany
  • :
Published Online: 2013-08-09 | DOI: https://doi.org/10.1515/jpm-2013-0074


Aims: The sFlt-1/PlGF ratio has been evaluated as a diagnostic marker for preeclampsia (PE). The aim of this study was to explore the use of the sFlt-1/PlGF ratio as an aid in prediction for PE.

Methods: 150 patients with a high risk for PE were enrolled in this prospective study. Groups were compared according to the pregnancy outcome: controls (n=114), intrauterine growth restriction (IUGR) (n=14) and PE (n=22) with subclassification early PE<34 weeks (n=6). Measurements of sFlt-1 and PlGF were performed on the automated Elecsys system. Statistical comparison of the sFlt-1/PlGF ratio in different outcome groups and a mixed model analysis using random intercept models were performed.

Results: The sFlt-1/PlGF ratio was significantly higher in pregnancies complicated by PE up to 4 weeks before clinical diagnosis compared to controls (106.7±47.7 vs. 21.0±4.1; P=0.02). Levels of the sFlt-1/PlGF ratio were higher throughout pregnancy in women with IUGR compared to PE/control patients (intercept 1.57 vs. 1.30/0.67; P<0.05). The slope for the sFlt-1/PlGF ratio was significantly higher in PE and IUGR pregnancies compared to controls, indicating that a steep increase of the sFlt-1/PlGF ratio correlates with pathologic pregnancy outcomes.

Conclusion: The sFlt-1/PlGF ratio can identify pathologic pregnancy outcomes such as IUGR and PE before clinical diagnosis. Repeated measurements are necessary to assess the dynamics in serum values. The time-dependent slope of the sFlt-1/PlGF ratio is predictive for future pregnancy outcome and risk of developing preeclampsia.

Keywords: Angiogenic factors; biomarker; hypertension; IUGR; placental dysfunction; PlGF; prediction; preeclampsia; pregnancy; sFlt-1

Corresponding author: Stefan Verlohren, Department of Obstetrics, Charité University Medicine, Berlin, Germany, E-mail:

Received: 2013-04-05

Accepted: 2013-07-08

Published Online: 2013-08-09

Published in Print: 2014-01-01

Citation Information: Journal of Perinatal Medicine. Volume 42, Issue 1, Pages 61–68, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm-2013-0074, August 2013

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Rafaela A. Costa, Mara S. Hoshida, Eliane A. Alves, Marcelo Zugaib, and Rossana P. V. Francisco
Hypertension in Pregnancy, 2016, Page 1
Sebastian Kwiatkowski, Ewa Kwiatkowska, Rafał Rzepka, Andrzej Torbe, and Barbara Dolegowska
The Journal of Maternal-Fetal & Neonatal Medicine, 2015, Page 1
D. Kappou, S. Sifakis, A. Konstantinidou, N. Papantoniou, and D. Spandidos
Experimental and Therapeutic Medicine, 2015
H. Stepan, I. Herraiz, D. Schlembach, S. Verlohren, S. Brennecke, F. Chantraine, E. Klein, O. Lapaire, E. Llurba, A. Ramoni, M. Vatish, D. Wertaschnigg, and A. Galindo
Ultrasound in Obstetrics & Gynecology, 2015, Volume 45, Number 3, Page 241
Yuxiu Liu, Yang Zhao, Ailing Yu, Bin Zhao, Yufang Gao, and Haitao Niu
Archives of Gynecology and Obstetrics, 2015
Yuanyuan Zhang, Yanfen Zou, Wenqi Wang, Qing Zuo, Ziyan Jiang, Ming Sun, Wei De, and Lizhou Sun
Journal of Cellular Biochemistry, 2015, Volume 116, Number 4, Page 542
Anjali Acharya, Wunnie Brima, Shivakanth Burugu, and Tanvi Rege
Current Hypertension Reports, 2014, Volume 16, Number 11
Kedak Baltajian, Jonathan L. Hecht, Julia B. Wenger, Saira Salahuddin, Stefan Verlohren, Frank H. Perschel, Zsuzsanna K. Zsengeller, Ravi Thadhani, S. Ananth Karumanchi, and Sarosh Rana
Hypertension in Pregnancy, 2014, Volume 33, Number 4, Page 427
Nathan S. Fox, Daniel H. Saltzman, Sandip Oppal, Chad K. Klauser, Simi Gupta, and Andrei Rebarber
American Journal of Obstetrics and Gynecology, 2014, Volume 211, Number 4, Page 422.e1
P. I. Gómez-Arriaga, I. Herraiz, E. A. López-Jiménez, D. Escribano, B. Denk, and A. Galindo
Ultrasound in Obstetrics & Gynecology, 2014, Volume 43, Number 5, Page 525

Comments (0)

Please log in or register to comment.