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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Milner, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

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In This Section
Volume 42, Issue 1 (Jan 2014)


Hepatitis C virus-associated thrombocytopenia in pregnancy: impact upon multidisciplinary care provision

Cathy Monteith
  • Department of Obstetrics, Rotunda Maternity Hospital, Dublin, Ireland
/ Fionnuala Ní Áinle
  • Department of Haematology, Rotunda Maternity Hospital, Dublin; Ireland and Mater Misericordiae Hospital, Dublin, Ireland
/ Sharon Cooley
  • Department of Obstetrics, Rotunda Maternity Hospital, Dublin, Ireland
/ John S. Lambert
  • Department of Infectious Diseases, Mater Misericordiae Hospital, Dublin, Ireland
/ Barry Kelleher
  • Department of Gastroenterology, Mater Misericordiae Hospital, Dublin, Ireland
/ Valerie Jackson
  • Department of Clinical Audit, Rotunda Maternity Hospital, Dublin, Ireland
/ Maeve Eogan
  • Corresponding author
  • Department of Obstetrics, Rotunda Maternity Hospital, Dublin, Ireland
  • Email:
Published Online: 2013-09-04 | DOI: https://doi.org/10.1515/jpm-2013-0080


Objective: Recent studies have implicated hepatitis C virus (HCV) in the pathogenesis of immune thrombocytopenia. In pregnancy-associated immune thrombocytopenia, multidisciplinary management is required due to a potential for bleeding complications. We performed a retrospective review of HCV-infected pregnant women and age-matched controls who were not infected with HCV.

Methods: One hundred and six women with a HCV viral load were identified from 2009 to 2011.

Results: Thrombocytopenia was identified in 10.3% of HCV-infected pregnant women and 1.6% of age-matched controls (P<0.001). Mean platelet count during pregnancy was 120±23×109/L in HCV-infected women and at delivery was significantly lower in HCV-infected women than in controls (P=0.01). Despite the significant difference in platelet counts, there was no significant difference in estimated blood loss (EBL) at delivery. Regional anaesthesia was performed in 73% of thrombocytopenic HCV-infected women and no complications were recorded. There were no fetal bleeding complications.

Conclusion: In the first study to date to investigate the impact of HCV on maternal platelet count we demonstrated a significantly higher frequency of thrombocytopenia and a significantly lower platelet count in HCV-infected pregnant women compared with controls. Interestingly, thrombocytopenia had no detectable impact on EBL at delivery.

Keywords: Hepatitis; platelets; thrombocytopenia


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About the article

Corresponding author: Dr Maeve Eogan, Department of Obstetrics, Rotunda Maternity Hospital, Dublin 1, Ireland, E-mail:

Received: 2013-04-10

Accepted: 2013-07-22

Published Online: 2013-09-04

Published in Print: 2014-01-01

Citation Information: Journal of Perinatal Medicine, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm-2013-0080. Export Citation

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