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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Konje, Justin C. / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica

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5-year IMPACT FACTOR: 1.578

CiteScore 2018: 1.29

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Source Normalized Impact per Paper (SNIP) 2018: 0.602

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Volume 42, Issue 1


Hepatitis C virus-associated thrombocytopenia in pregnancy: impact upon multidisciplinary care provision

Cathy Monteith / Fionnuala Ní Áinle
  • Department of Haematology, Rotunda Maternity Hospital, Dublin; Ireland and Mater Misericordiae Hospital, Dublin, Ireland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Sharon Cooley / John S. Lambert / Barry Kelleher / Valerie Jackson / Maeve Eogan
Published Online: 2013-09-04 | DOI: https://doi.org/10.1515/jpm-2013-0080


Objective: Recent studies have implicated hepatitis C virus (HCV) in the pathogenesis of immune thrombocytopenia. In pregnancy-associated immune thrombocytopenia, multidisciplinary management is required due to a potential for bleeding complications. We performed a retrospective review of HCV-infected pregnant women and age-matched controls who were not infected with HCV.

Methods: One hundred and six women with a HCV viral load were identified from 2009 to 2011.

Results: Thrombocytopenia was identified in 10.3% of HCV-infected pregnant women and 1.6% of age-matched controls (P<0.001). Mean platelet count during pregnancy was 120±23×109/L in HCV-infected women and at delivery was significantly lower in HCV-infected women than in controls (P=0.01). Despite the significant difference in platelet counts, there was no significant difference in estimated blood loss (EBL) at delivery. Regional anaesthesia was performed in 73% of thrombocytopenic HCV-infected women and no complications were recorded. There were no fetal bleeding complications.

Conclusion: In the first study to date to investigate the impact of HCV on maternal platelet count we demonstrated a significantly higher frequency of thrombocytopenia and a significantly lower platelet count in HCV-infected pregnant women compared with controls. Interestingly, thrombocytopenia had no detectable impact on EBL at delivery.

Keywords: Hepatitis; platelets; thrombocytopenia


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About the article

Corresponding author: Dr Maeve Eogan, Department of Obstetrics, Rotunda Maternity Hospital, Dublin 1, Ireland, E-mail:

Received: 2013-04-10

Accepted: 2013-07-22

Published Online: 2013-09-04

Published in Print: 2014-01-01

Citation Information: Journal of Perinatal Medicine, Volume 42, Issue 1, Pages 135–138, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm-2013-0080.

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