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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Reiss, Irwin / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

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Volume 42, Issue 1 (Jan 2014)

Issues

Effect of high-fat diet prior to pregnancy on hepatic gene expression and histology in mouse offspring

Hiroshi Hori
  • Faculty of Pharmaceutical Sciences, Department of Hygienic Chemistry, Tokyo University of Science, Yamazaki, Noda, Japan
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/ Masakazu Umezawa
  • Corresponding author
  • Faculty of Pharmaceutical Sciences, Department of Hygienic Chemistry, Tokyo University of Science, Yamazaki, Noda, Japan
  • The Center for Environmental Health Science for the Next Generation, Research Institute for Science and Technology, Tokyo University of Science, Yamazaki, Noda, Japan
  • Email
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/ Mariko Uchiyama
  • Faculty of Pharmaceutical Sciences, Department of Hygienic Chemistry, Tokyo University of Science, Yamazaki, Noda, Japan
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/ Rikio Niki
  • The Center for Environmental Health Science for the Next Generation, Research Institute for Science and Technology, Tokyo University of Science, Yamazaki, Noda, Japan
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/ Shinya Yanagita
  • The Center for Environmental Health Science for the Next Generation, Research Institute for Science and Technology, Tokyo University of Science, Yamazaki, Noda, Japan
  • Faculty of Science and Technology, Tokyo University of Science, Yamazaki, Noda, Japan
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/ Ken Takeda
  • Faculty of Pharmaceutical Sciences, Department of Hygienic Chemistry, Tokyo University of Science, Yamazaki, Noda, Japan
  • The Center for Environmental Health Science for the Next Generation, Research Institute for Science and Technology, Tokyo University of Science, Yamazaki, Noda, Japan
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Published Online: 2013-08-24 | DOI: https://doi.org/10.1515/jpm-2013-0091

Abstract

Maternal overnutrition and obesity are associated with fetal development and cause long-term effects in offspring. However, the effects of a high-fat diet specific to the pre-pregnancy period are not determined. The present study aimed to examine the effect of high-fat diet prior to pregnancy on the liver of mouse offspring. Female C57BL/6J mice were fed a normal chow (15.2% fat by energy) [control diet (CTR) and CTR pre-pregnancy (PP) groups] or a high-fat chow (31.2% fat by energy) [high-fat diet (HFD) and HFD-pre-pregnancy (PP) groups] for 3–4 weeks and then mated with male C57BL/6J mice fed normal chow. Some mothers continued on the same diet until pups reached 21 days of age (CTR and HFD), and others were fed the different chows from gestational day 0 (CTR-PP and HFD-PP) to determine the effects of a high-fat diet during the pre-pregnancy period in HFD-PP/CTR and HFD/CTR-PP comparisons. Liver tissues from pups were subjected to gene expression analysis by quantitative reverse transcription-polymerase chain reaction (RT-PCR) and microarray, and histological analysis using Oil Red O staining (Sigma Chemical Co., Ltd., Balcatta, WA, USA). Lipid droplets were increased in hepatocytes of mice in HFD-PP compared to CTR and those in HFD compared to CTR-PP. Expression of stearoyl-coenzyme A desaturase 1 (Scd1), acetyl-coenzyme A carboxylase beta (Acacb), and fatty acid binding protein 5 (Fabp5) was increased by maternal high-fat diet during pre-pregnancy. The results showed that maternal high-fat diet intake prior to pregnancy uniquely affects metabolic phenotype related to health and disease in the liver of the next generation.

This article offers supplementary material which is provided at the end of the article.

Keywords: High-fat diet; liver; microarray; pregnancy; prenatal nutrition

References

  • [1]

    Abu-Elheiga L, Matzuk MM, Abo-Hashema KA, Wakil SJ. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science. 2001;291:2613–6.Google Scholar

  • [2]

    Armitage JA, Lakasing L, Taylor PD, Balachandran AA, Jensen RI, Dekou V, et al. Developmental programming of aortic and renal structure in offspring of rats fed fat-rich diets in pregnancy. J Physiol. 2005;565:171–84.Google Scholar

  • [3]

    Armitage JA, Taylor PD, Poston L. Experimental models of developmental programming: consequences of exposure to an energy rich diet during development. J Physiol. 2005;565:3–8.Google Scholar

  • [4]

    Ayonrinde OT, Olynyk JK, Beilin LJ, Mori TA, Pennell CE, de Klerk N, et al. Gender-specific differences in adipose distribution and adipocytokines influence adolescent nonalcoholic fatty liver disease. Hepatology. 2011;53:800–9.CrossrefWeb of ScienceGoogle Scholar

  • [5]

    Brazma A, Hingamp P, Quackenbush J, Sherlock G, Spellman P, Stoeckert C, et al. Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat Genet. 2001;29:365–71.PubMedCrossrefGoogle Scholar

  • [6]

    Carbone DL, Zuloaga DG, Hiroi R, Foradori CD, Legare ME, Handa RJ. Prenatal dexamethasone exposure potentiates diet-induced hepatosteatosis and decreases plasma IGF-I in a sex-specific fashion. Endocrinology. 2012;153:295–306.Web of ScienceGoogle Scholar

  • [7]

    Cerf ME, Williams K, Nkomo XI, Muller CJ, Du Toit DF, Louw J, et al. Islet cell response in the neonatal rat after exposure to a high-fat diet during pregnancy. Am J Physiol Regul Integr Comp Physiol. 2005;288:R1122–8.Google Scholar

  • [8]

    Chang GQ, Gaysinskaya V, Karatayev O, Leibowitz SF. Maternal high-fat diet and fetal programming: increased proliferation of hypothalamic peptide-producing neurons that increase risk for overeating and obesity. J Neurosci. 2008;28:12107–19.PubMedWeb of ScienceCrossrefGoogle Scholar

  • [9]

    Chen H, Simar D, Lambert K, Mercier J, Morris MJ. Maternal and postnatal overnutrition differentially impact appetite regulators and fuel metabolism. Endocrinology. 2008;149:5348–56.PubMedWeb of ScienceCrossrefGoogle Scholar

  • [10]

    Dell PA, Rose FD. Transfer of effects from environmentally enriched and improvement female rats to future offspring. Physiol Behav. 1987:39:187–90.CrossrefGoogle Scholar

  • [11]

    De Lusong MA, Labio E, Daez L, Gloria V. Non-alcoholic fatty liver disease in the Philippines: comparable with other nations? World J Gastroenterol. 2008;14:913–7.CrossrefPubMedGoogle Scholar

  • [12]

    Dunn GA, Bale TL. Maternal high-fat diet promotes body length increases and insulin insensitivity in second-generation mice. Endocrinology. 2009;150:4999–5009.Web of SciencePubMedCrossrefGoogle Scholar

  • [13]

    Eguchi Y, Hyogo H, Ono M, Mizuta T, Ono N, Fujimoto K, et al. Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan: a multicenter large retrospective study. J Gastroenterol. 2012;47:586–95.Web of ScienceCrossrefPubMedGoogle Scholar

  • [14]

    Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA. 1998;95:14863–8.CrossrefGoogle Scholar

  • [15]

    Flores I, Rivera E, Ruiz LA, Santiago OI, Vernon MW, Appleyard CB. Molecular profiling of experimental endometriosis identified gene expression patterns in common with human disease. Fertil Steril. 2007;87:1180–99.Web of SciencePubMedCrossrefGoogle Scholar

  • [16]

    Furuhashi M, Hotamisligil GS. Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nat Rev Drug Discov. 2008;7:489–503.PubMedCrossrefWeb of ScienceGoogle Scholar

  • [17]

    Furuhashi M, Ishimura S, Ota H, Miura T. Lipid chaperones and metabolic inflammation. Int J Inflam. 2011;2011:642612.PubMedGoogle Scholar

  • [18]

    Ghebremeskel K, Bitsanis D, Koukkou E, Lowy C, Poston L, Crawford MA. Maternal diet high in fat reduces docosahexaenoic acid in liver lipids of newborn and sucking rat pups. Br J Nutr. 1999;81:395–404.PubMedGoogle Scholar

  • [19]

    Gluckman PD, Hanson MA. Living with the past: evolution, development, and patterns of disease. Science. 2004;305:1733–36.Google Scholar

  • [20]

    Godfrey KM, Barker DJ. Fetal nutrition and adult disease. Am J Clin Nutr. 2000;71:1344S–52S.Google Scholar

  • [21]

    Haentjens P, Massaad D, Reynaert H, Peeters E, Van Meerhaeghe A, Vinken S, et al. Identifying non-alcoholic fatty liver disease among asymptomatic overweight and obese individuals by clinical and biochemical characteristics. Acta Clin Belg. 2009;64:483–93.PubMedGoogle Scholar

  • [22]

    Hales CN, Barker DJ. The thrifty phenotype hypothesis. Br Med Bull. 2001;60:5–20.CrossrefPubMedGoogle Scholar

  • [23]

    Harada N, Oda Z, Hara Y, Fujinami K, Okawa M, Ohbuchi K, et al. Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice. Mol Cell Biol. 2007;27:1881–8.Web of SciencePubMedGoogle Scholar

  • [24]

    Hatori M, Vollmers C, Zarrinpar A, DiTacchio L, Bushong EA, Gill S, et al. Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell Metab. 2012;15:848–60.CrossrefPubMedWeb of ScienceGoogle Scholar

  • [25]

    Igal RA. Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer. Carcinogenesis. 2010;31:1509–15.PubMedWeb of ScienceGoogle Scholar

  • [26]

    Innis SM. Human milk: maternal dietary lipids and infant development. Proc Nutr Soc. 2007;66:397–404.PubMedWeb of ScienceCrossrefGoogle Scholar

  • [27]

    Khan IY, Taylor PD, Dekou V, Seed PT, Lakasing L, Graham D, et al. Gender-linked hypertension in offspring of lard-fed pregnant rats. Hypertension. 2003;41:168–75.PubMedCrossrefGoogle Scholar

  • [28]

    Koh JH, Shin YG, Nam SM, Lee MY, Chung CH, Shin JY. Serum adipocyte fatty acid-binding protein levels are associated with nonalcoholic fatty liver disease in type 2 diabetic patients. Diabetes Care. 2009;32:147–52.PubMedGoogle Scholar

  • [29]

    Koukkou E, Ghosh P, Lowy C, Poston L. Offspring of normal and diabetic rats fed saturated fat in pregnancy demonstrate vascular dysfunction. Circulation. 1998;98:2899–904.CrossrefPubMedGoogle Scholar

  • [30]

    Leme AS, Hubeau C, Xiang Y, Goldman A, Hamada K, Suzaki Y, et al. Role of breast milk in a mouse model of maternal transmission of asthma susceptibility. J Immunol. 2006;176:762–9.Google Scholar

  • [31]

    Ma Y, Zhu MJ, Zhang L, Hein SM, Nathanielsz PW, Ford SP. Maternal obesity and overnutrition alter fetal growth rate and cotyledonary vascularity and angiogenic factor expression in the ewe. Am J Physiol Regul Integr Comp Physiol. 2010;299:R249–58.Web of ScienceGoogle Scholar

  • [32]

    Mingrone G, Manco M, Mora ME, Guidone C, Iaconelli A, Gniuli D, et al. Influence of maternal obesity on insulin sensitivity and secretion in offspring. Diabetes Care. 2008;31:1872–6.PubMedCrossrefWeb of ScienceGoogle Scholar

  • [33]

    Mitsuyoshi H, Yasui K, Harano Y, Endo M, Tsuji K, Minami M, et al. Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease. Hepatol Res. 2009;39:366–73.PubMedCrossrefWeb of ScienceGoogle Scholar

  • [34]

    Miyazaki M, Flowers MT, Sampath H, Chu K, Otzelberger C, Liu X, et al. Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis. Cell Metab. 2007;6:484–96.Web of SciencePubMedGoogle Scholar

  • [35]

    Muhlhausler BS, Adam CL, Findlay PA, Duffield JA, McMillen IC. Increased maternal nutrition alters development of the appetite-regulating network in the brain. FASEB J. 2006;20:1257–9.PubMedWeb of ScienceCrossrefGoogle Scholar

  • [36]

    Ntambi JM, Miyazaki M, Stoehr JP, Lan H, Kendziorski CM, Yandell BS, et al. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci USA. 2002;99:11482–6.Google Scholar

  • [37]

    Oben JA, Mouralidarane A, Samuelsson AM, Matthews PJ, Morgan ML, McKee C, et al. Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice. J Hepatol. 2010;52:913–20.CrossrefWeb of SciencePubMedGoogle Scholar

  • [38]

    Oken E, Gillman MW. Fetal origins of obesity. Obes Res. 2003;11:496–506.CrossrefPubMedGoogle Scholar

  • [39]

    Peng Y, Rideout D, Rakita S, Lee J, Murr M. Diet-induced obesity associated with steatosis, oxidative stress, and inflammation in liver. Surg Obes Relat Dis. 2012;8:73–81.PubMedCrossrefWeb of ScienceGoogle Scholar

  • [40]

    Quackenbush J. Computational analysis of microarray data. Nat Rev Genet. 2001;2:418–27.CrossrefPubMedGoogle Scholar

  • [41]

    Rajia S, Chen H, Morris MJ. Maternal overnutrition impacts offspring adiposity and brain appetite markers-modulation by postweaning diet. J Neuroendocrinol. 2010;22:905–14.PubMedWeb of ScienceGoogle Scholar

  • [42]

    Saldanha AJ. Java Treeview – extensible visualization of microarray data. Bioinformatics. 2004;20:3246–8.CrossrefPubMedGoogle Scholar

  • [43]

    Sebire NJ, Jolly M, Harris JP, Wadsworth J, Joffe M, Beard RW, et al. Maternal obesity and pregnancy outcome: a study of 287,213 pregnancies in London. Int J Obes Relat Metab Disord. 2001;25:1175–82.Google Scholar

  • [44]

    Srinivasan M, Katewa SD, Palaniyappan A, Pandya JD, Patel MS. Maternal high-fat diet consumption results in fetal malprogramming predisposing to the onset of metabolic syndrome-like phenotype in adulthood. Am J Physiol Endocrinol Metab. 2006;291:E792–9.Google Scholar

  • [45]

    Sun Z, Miller RA, Patel RT, Chen J, Dhir R, Wang H, et al. Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. Nat Med. 2012;18:934–42.Web of ScienceGoogle Scholar

  • [46]

    Umezawa M, Tanaka N, Tainaka H, Takeda K, Ihara T, Sugamata M. Microarray analysis provides insight into the early steps of pathophysiology of mouse endometriosis model induced by autotransplantation of endometrium. Life Sci. 2009;84:832–7.PubMedWeb of ScienceCrossrefGoogle Scholar

  • [47]

    Wu Q, Suzuki M. Parental obesity and overweight affect the body-fat accumulation in the offspring: the possible effect of a high-fat diet through epigenetic inheritance. Obes Rev. 2006;7:201–8.PubMedCrossrefGoogle Scholar

  • [48]

    Wu M, Singh SB, Wang J, Chung CC, Salituro G, Karanam BV, et al. Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes. Proc Natl Acad Sci USA. 2011;108:5378–83.Web of ScienceCrossrefGoogle Scholar

  • [49]

    Xu G, Umezawa M, Takeda K. Early development origins of adult disease caused by malnutrition and environmental chemical substances. J Health Sci. 2009;55:11–9.CrossrefWeb of ScienceGoogle Scholar

  • [50]

    Zahurak M, Parmigiani G, Yu W, Scharpf RB, Berman D, Schaeffer E, et al. Pre-processing Agilent microarray data. BMC Bioinformatics. 2007;8:142.CrossrefWeb of SciencePubMedGoogle Scholar

About the article

Corresponding author: Masakazu Umezawa, Faculty of Pharmaceutical Sciences, Department of Hygienic Chemistry, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan; and The Center for Environmental Health Science for the Next Generation, Research Institute for Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan, E-mail:


Received: 2013-04-24

Accepted: 2013-07-26

Published Online: 2013-08-24

Published in Print: 2014-01-01


Citation Information: Journal of Perinatal Medicine, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm-2013-0091.

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