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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Milner, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

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1619-3997
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Volume 42, Issue 1 (Jan 2014)

Issues

Short and medium-term outcomes of live-born twins after fetoscopic laser therapy for twin-twin transfusion syndromea

Barthélémy Tosello
  • Corresponding author
  • Department of Neonatology, Assistance Publique des Hôpitaux de Marseille (APHM), Hôpital Nord, Marseille, France
  • University of Medicine of Marseille, Université de la Méditerranée, Marseille, France
  • Email:
/ Julie Blanc
  • Department of Obstetrics and Gynecology, Assistance Publique des Hôpitaux de Marseille (APHM), Hôpital Nord, Marseille, France
/ Jean-Baptiste Haumonté
  • Department of Obstetrics and Gynecology, Assistance Publique des Hôpitaux de Marseille (APHM), Hôpital Nord, Marseille, France
/ Claude D’Ercole
  • Department of Obstetrics and Gynecology, Assistance Publique des Hôpitaux de Marseille (APHM), Hôpital Nord, Marseille, France
  • University of Medicine of Marseille, Université de la Méditerranée, Marseille, France
/ Catherine Gire
  • Department of Neonatology, Assistance Publique des Hôpitaux de Marseille (APHM), Hôpital Nord, Marseille, France
Published Online: 2013-09-05 | DOI: https://doi.org/10.1515/jpm-2013-0119

Abstract

Objective: To evaluate short and medium term outcomes of children born of monochorionic pregnancies complicated by twin-twin transfusion syndrome treated by fetoscopic laser surgery.

Methods: This was a retrospective observational study performed between May 2007 and 2012. Neonatal data was from 45 patients under 5 years of age. The prospective observational study was of the neurologic outcome of these children using the Ages and Stages Questionnaire (ASQ), 2nd edition, French version, at up to 5 years of age.

Results: Neurologic assessment at discharge from maternity unit was normal for 41 infants (93.2%). Logistic regression suggested that the risk of neurosensory sequelae was significantly related to the status of donor [odds ratio=4.62 (1.18; 18.0)] and significantly preterm birth <32 weeks of gestation [odds ratio=5.50 (1.38; 21.9)]. Eleven questionnaires were considered abnormal (31.1%). Two children presented a severe neurologic abnormality (5.7%). There was no significant correlation between any area of the questionnaire and status at birth (donor or recipient).

Conclusions: The data from our cohort, particularly as regards neurologic outcome, were satisfactory and concordant with previously published results. The use of the ASQ as a screening tool for neurologic outcome in children is original, which allowed in our cohort to highlight early neurological disorders.

Keywords: Fetoscopy laser surgery; neurodevelopmental outcome; twin-twin transfusion syndrome

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About the article

Corresponding author: Dr. Barthélémy Tosello, Service de Néonatologie, Assistance Publique des Hôpitaux de Marseille (APHM), Hôpital Nord, Chemin des Bourrely, 13015 Marseille, France, Tel.: +33 6 45 91 82 86, Fax: +33 4 91 96 46 75, E-mail:


Received: 2013-05-29

Accepted: 2013-08-14

Published Online: 2013-09-05

Published in Print: 2014-01-01


Presented at the 42nd Meeting of the French Society of Perinatal Medicine, Montpellier, France, October 19, 2012.


Citation Information: Journal of Perinatal Medicine, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm-2013-0119.

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