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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, Marc J.N.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

9 Issues per year


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1619-3997
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Volume 42, Issue 1 (Jan 2014)

Issues

Fetal volume at 11–14 gestational weeks: reference ranges and association with first trimester biochemical and biophysical markers

Ioannis Papastefanou
  • Corresponding author
  • Fetal Medicine Unit, 3 Department of Obstetrics and Gynecology, Athens Medical School, National and Kapodistrian University of Athens, “Attikon” University Hospital, Athens, Greece
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/ Dimitra Kappou
  • Fetal Medicine Unit, 3 Department of Obstetrics and Gynecology, Athens Medical School, National and Kapodistrian University of Athens, “Attikon” University Hospital, Athens, Greece
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/ Athena P. Souka
  • Fetal Medicine Unit, 3 Department of Obstetrics and Gynecology, Athens Medical School, National and Kapodistrian University of Athens, “Attikon” University Hospital, Athens, Greece
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/ Charalambos Chrelias
  • Fetal Medicine Unit, 3 Department of Obstetrics and Gynecology, Athens Medical School, National and Kapodistrian University of Athens, “Attikon” University Hospital, Athens, Greece
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/ Charalambos Siristatidis
  • Fetal Medicine Unit, 3 Department of Obstetrics and Gynecology, Athens Medical School, National and Kapodistrian University of Athens, “Attikon” University Hospital, Athens, Greece
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/ Athanasios Pilalis
  • Fetal Medicine Unit, 3 Department of Obstetrics and Gynecology, Athens Medical School, National and Kapodistrian University of Athens, “Attikon” University Hospital, Athens, Greece
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/ Demetrios Kassanos
  • Fetal Medicine Unit, 3 Department of Obstetrics and Gynecology, Athens Medical School, National and Kapodistrian University of Athens, “Attikon” University Hospital, Athens, Greece
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Published Online: 2013-09-07 | DOI: https://doi.org/10.1515/jpm-2013-0158

Abstract

Aims: To establish reference ranges for fetal volume (FV) measured by three-dimensional ultrasound (3D-US) at 11–14 weeks of gestation and to examine the possible association of FV with maternal/pregnancy characteristics and biochemical parameters.

Methods: Prospective observational study on 240 fetuses at 11–14 weeks. FV was measured by 3D-US using Virtual Organ Computer-Aided Analysis. Pearson correlation coefficient (cc) and regression analysis were used.

Results: FV increased exponentially with crown rump length and was unrelated to maternal weight (cc=–0.137, P=0.071), age (cc=0.009, P=0.899), parity (0.76), smoking status (t-test, P=0.149) and mode of conception (t-test, P=0.8). Z-scores (z) of FV was not associated with z-mean uterine artery pulsatility index (cc=–0.026, P=0.733), log10 multiples of the median (MoM) free beta human chorionic gonadotrophin (cc=0.002, P=0.982), delta value (d) of nuchal translucency (cc=0.072, P=0.331) and d-fetal heart rate (cc=0.009, P=0.902), z-FV was significantly positively correlated with log10 MoM pregnancy associated plasma protein-A (PAPP-A; regression coefficient=1.420976, R2=0.0957, P<0.0001).

Conclusions: FV is strongly related to PAPP-A even after adjustment for crown rump length with a mechanism unrelated to placental perfusion. FV is independent of the vast majority of first trimester parameters; hence, it is a promising marker of early fetal growth.

Keywords: 3-Dimensional ultrasound; fetal volume; first trimester ultrasound scan; free-β hcG; PAPP-A; uterine artery pulsatility index; VOCAL

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About the article

Corresponding author: Dr. Ioannis Papastefanou, Fetal Medicine Unit, Athens Medical School, National and Kapodistrian University of Athens, 3rd Department of Obstetrics and Gynecology, “Attikon” University Hospital, Rimini 1, 124-62, Haidari, Athens, Greece, Tel.: +30-210-5832236, Fax: +30-210-5826447, E-mail:


Received: 2013-06-30

Accepted: 2013-08-15

Published Online: 2013-09-07

Published in Print: 2014-01-01


Citation Information: Journal of Perinatal Medicine, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm-2013-0158.

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