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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica


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1619-3997
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Volume 44, Issue 2

Issues

Fetal nasal bone length in the second trimester: comparison between population groups from different ethnic origins

Panayiota Papasozomenou
  • Corresponding author
  • 1 Department of Obstetrics and Gynecology, Papageorgiou Hospital, Medical School, Aristotle University of Thessaloniki, Greece
  • Prenatal Diagnostic Center of Thessaloniki, Thessaloniki, Greece
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/ Apostolos P. Athanasiadis
  • 1 Department of Obstetrics and Gynecology, Papageorgiou Hospital, Medical School, Aristotle University of Thessaloniki, Greece
  • Prenatal Diagnostic Center of Thessaloniki, Thessaloniki, Greece
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/ Menelaos Zafrakas
  • 1 Department of Obstetrics and Gynecology, Papageorgiou Hospital, Medical School, Aristotle University of Thessaloniki, Greece
  • School of Health and Medical Care, Alexander Technological Institute of Thessaloniki, Greece
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/ Eleftherios Panteris / Aristoteles Loufopoulos
  • 2 Department of Obstetrics and Gynecology, Hippokratio Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
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/ Efstratios Assimakopoulos
  • 2 Department of Obstetrics and Gynecology, Hippokratio Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
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/ Basil C. Tarlatzis
  • 1 Department of Obstetrics and Gynecology, Papageorgiou Hospital, Medical School, Aristotle University of Thessaloniki, Greece
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Published Online: 2014-12-15 | DOI: https://doi.org/10.1515/jpm-2014-0296

Abstract

Objective: To compare normal ranges of ultrasonographically measured fetal nasal bone length in the second trimester between different ethnic groups.

Method: A prospective, non-interventional study in order to establish normal ranges of fetal nasal bone length in the second trimester in a Greek population was conducted in 1220 singleton fetuses between 18 completed weeks and 23 weeks and 6 days of gestation. A literature search followed in order to identify similar studies in different population groups. Fetal nasal bone length mean values and percentiles from different population groups were compared.

Results: Analysis of measurements in the Greek population showed a linear association, i.e., increasing nasal bone length with increasing gestational age from 5.73 mm at 18 weeks to 7.63 mm at 23 weeks. Eleven studies establishing normal ranges of fetal nasal bone length in the second trimester were identified. Comparison of fetal nasal bone length mean values between the 12 population groups showed statistically significant differences (P<0.0001).

Conclusion: Normal ranges of fetal nasal bone length in the second trimester vary significantly between different ethnic groups. Hence, distinct ethnic nomograms of fetal nasal bone length in the second trimester should be used in a given population rather than an international model.

Keywords: Fetal nasal bone length; fetal ultrasound; gestational age; maternal ethnic origin; normal range; second trimester

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About the article

Corresponding author: Panayiota Papasozomenou, Obstetrician Gynecologist, Ethnikis Antistaseos 81, GR-55134, Thessaloniki, Greece, Tel.: +302310-444364, Fax: +302310222498, E-mail:


Received: 2014-09-03

Accepted: 2014-11-10

Published Online: 2014-12-15

Published in Print: 2016-03-01


Citation Information: Journal of Perinatal Medicine, Volume 44, Issue 2, Pages 229–235, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm-2014-0296.

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