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Licensed Unlicensed Requires Authentication Published by De Gruyter August 13, 2015

Antenatal risk factors for symptomatic congenital CMV disease following primary maternal CMV infection

  • Eran Hadar EMAIL logo , Liat Salzer , Elizabeta Dorfman , Jacob Amir and Joseph Pardo

Abstract

Objectives: This study aimed to evaluate antenatal risk factors associated with symptomatic congenital cytomegalovirus (CMV) disease, following in utero vertical infection.

Methods: This study included a retrospective cohort of 155 neonates with congenital CMV infection, following primary maternal CMV infection during pregnancy, and were divided to symptomatic (n=95) and asymptomatic (n=60) newborns.

Results: Young maternal age (29.1±5.12 vs. 31.6±5.36 years, P=0.005), high risk occupation for viral exposure (20.0% vs. 11.7%, P=0.04), CMV IgG seroconversion at diagnosis (83.1% vs. 63.3%, P=0.005) and abnormal fetal MRI (11.6% vs. 0%, P=0.003) were found to be prognostic risk factors associated with symptomatic CMV disease of the newborn. Maternal febrile illness at diagnosis, IgG avidity, US findings and the timing of maternal infection were not associated with the occurrence of neonatal symptoms.

Conclusions: Knowledge of the reported risk factors may assist in counseling parents with intra uterine CMV infection.

References

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The authors stated that there are no conflicts of interest regarding the publication of this article.

Received: 2014-10-18
Accepted: 2015-7-22
Published Online: 2015-8-13
Published in Print: 2016-4-1

©2016 by De Gruyter

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