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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Konje, Justin C. / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica


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1619-3997
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Volume 44, Issue 7

Issues

Maternal characteristics of pregnancies with intrauterine fetal demise

Asnat Walfisch / Richard Brown / Angela Mallozzi / Mordechai Hallak
  • Department of Obstetrics and Gynecology, Hillel-Yaffe Medical Center, Hadera, Israel, affiliated with The Bruce and Ruth Rappaport Faculty of Medicine, Technion, Israel Institute of Technology
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Alon Shrim
  • Department of Obstetrics and Gynecology, Hillel-Yaffe Medical Center, Hadera, Israel, affiliated with The Bruce and Ruth Rappaport Faculty of Medicine, Technion, Israel Institute of Technology
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2015-06-30 | DOI: https://doi.org/10.1515/jpm-2015-0135

Abstract

Objective:

To identify maternal characteristics independently associated with pregnancies resulting in intrauterine fetal demise (IUFD).

Study design:

This was a population-based cohort study of all births taking place at the McGill University Health Centre in Montreal, Canada, between 2001 and 2007, using the McGill University Obstetrics and Neonatal Database. Maternal characteristics were compared between pregnancies that resulted in IUFD and control pregnancies resulting in live newborns. A logistic regression analysis was constructed to identify parameters independently associated with IUFD.

Results:

We identified 20,744 births during the study period, 87 of which were complicated by IUFD. Mothers with IUFD were more likely to be younger, with less formal education, higher rates of smoking during pregnancy, and more fetal anomalies (42.5% vs. 7.5%, P<0.001). After exclusion of pregnancies with congenital and/or chromosomal abnormalities, less formal education (7 vs. 13.6 school years, P<0.001) and smoking during pregnancy (24% vs. 7.7%, P<0.001) remained significantly more common in pregnancies resulting in IUFD. In the multivariable regression analysis both smoking and number of maternal school years were independently associated with IUFD pregnancies (OR 2.22 for smoking, P=0.007 and OR 0.865 for number of school years, P<0.001).

Conclusion:

Lower levels of education and smoking during pregnancy are independent predictors of IUFD.

Keywords: Fetal death; maternal education; maternal smoking; maternal socioeconomical status; risk factors; stillbirth

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About the article

Corresponding author: Dr. Asnat Walfisch, Department of Obstetrics and Gynecology, Hillel Yaffe Medical Center, Hadera, Israel, Tel.: +972 50 4492200, Fax: +972 4 6188225, E-mail:


Received: 2015-04-26

Accepted: 2015-06-02

Published Online: 2015-06-30

Published in Print: 2016-10-01


Disclosure of interests: All authors declare that no authors (nor their institutions) received payments for their efforts on this project. The authors report no conflict of interest.

Contribution to authorship: AS conceived the study, led the design and plans for analysis, drafted the manuscript, and is the guarantor for the study. All co-authors (AW, RB, AM, MH, AS) contributed to the design, analysis plan, and editing of the manuscript. All authors approved the final version of the submitted manuscript.

Details of ethics approval: The study was approved by the institutional review board of McGill University Health Center (reference number: 12-438-SDR) April 2013.

Funding: This study was not funded.

The authors stated that there are no conflicts of interest regarding the publication of this article.


Citation Information: Journal of Perinatal Medicine, Volume 44, Issue 7, Pages 779–784, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm-2015-0135.

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