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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica


IMPACT FACTOR 2018: 1.361
5-year IMPACT FACTOR: 1.578

CiteScore 2018: 1.29

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Source Normalized Impact per Paper (SNIP) 2018: 0.602

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1619-3997
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Volume 45, Issue 1

Issues

Antenatal corticosteroids: current controversies

Isaac Blickstein
Published Online: 2016-04-06 | DOI: https://doi.org/10.1515/jpm-2015-0405

References

  • [1]

    Antenatal Corticosteroids Revisited: Repeat Courses. NIH Consens Statement 2000 August 17–18;17:1–10.Google Scholar

  • [2]

    Roberts D, Dalziel S. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev. 2006;19:CD004454.Google Scholar

  • [3]

    Wapner RJ. Antenatal corticosteroids for periviable birth. Semin Perinatol. 2013;37:410–3.Google Scholar

  • [4]

    Stutchfield P, Whitaker R, Russell I. Antenatal Steroids for Term Elective Caesarean Section (ASTECS) Research Team. Antenatal betamethasone and incidence of neonatal respiratory distress after elective caesarean section: pragmatic randomised trial. Br Med J. 2005;331:662.Google Scholar

  • [5]

    Ahmed MR, Sayed Ahmed WA, Mohammed TY. Antenatal steroids at 37 weeks, does it reduce neonatal respiratory morbidity? A randomized trial. J Matern Fetal Neonatal Med. 2014;22:1–5.Google Scholar

  • [6]

    Kamath-Rayne BD, DeFranco EA, Marcotte MP. Antenatal steroids for treatment of fetal lung immaturity after 34 weeks of gestation: an evaluation of neonatal outcomes. Obstet Gynecol. 2012;119:909–16.Google Scholar

  • [7]

    Stutchfield PR, Whitaker R, Gliddon AE, Hobson L, Kotecha S, Doull IJM. Behavioural, educational and respiratory outcomes of antenatal betamethasone for term caesarean section (ASTECS trial). Arch Dis Child Fetal Neonatal Ed. 2013;98:F195–200.Web of ScienceGoogle Scholar

  • [8]

    Sifianou P, Thanou V, Karga H. Metabolic and hormonal effects of antenatal betamethasone after 35 weeks of gestation. J Pediatr Pharmacol Ther. 2015;20:138–43.Google Scholar

  • [9]

    Aiken CE, Fowden AL, Smith GC. Antenatal glucocorticoids prior to cesarean delivery at term. JAMA Pediatr. 2014;168:507–8.Google Scholar

  • [10]

    Baud O, Foix-L’Helias L, Kaminski M, Audibert F, Jarreau PH, Papiernik E, et al. Antenatal glucocorticoid treatment and cystic periventricular leukomalacia in very premature infants. N Engl J Med. 1999;341:1190–6.Google Scholar

  • [11]

    Canterino JC, Verma U, Visintainer PF, Elimian A, Klein SA, Tejani N. Antenatal steroids and neonatal periventricular leukomalacia. Obstet Gynecol. 2001;97:135–9.Google Scholar

  • [12]

    Lee BH, Stoll BJ, McDonald SA, Higgins RD. National Institute of Child Health and Human Development Neonatal Research Network. Adverse neonatal outcomes associated with antenatal dexamethasone versus antenatal betamethasone. Pediatrics. 2006;117:1503–10.Google Scholar

  • [13]

    Lee BH, Stoll BJ, McDonald SA, Higgins RD. National Institute of Child Health and Human Development Neonatal Research Network. Neurodevelopmental outcomes of extremely low birth weight infants exposed prenatally to dexamethasone versus betamethasone. Pediatrics. 2008;121:289–96.Google Scholar

  • [14]

    Sasaki Y, Ikeda T, Nishimura K, Katsuragi S, Sengoku K, Kusuda S, et al. Association of antenatal corticosteroids and the mode of delivery with the mortality and morbidity of infants weighing less than 1,500 g at birth in Japan. Neonatology. 2014;106:81–6.Google Scholar

  • [15]

    Morrison JL, Botting KJ, Soo PS, McGillick EV, Hiscock J, Zhang S, et al. Antenatal steroids and the IUGR fetus: are exposure and physiological effects on the lung and cardiovascular system the same as in normally grown fetuses? J Pregnancy. 2012;2012:839656.Google Scholar

  • [16]

    Mitsiakos G, Kovacs L, Papageorgiou A. Are antenatal steroids beneficial to severely growth restricted fetuses? J Matern Fetal Neonatal Med. 2013;26:1496–9.Google Scholar

  • [17]

    Hodges RJ, Wallace EM. Mending a growth-restricted fetal heart: should we use glucocorticoids? J Matern Fetal Neonatal Med. 2012;25:2149–53.Google Scholar

  • [18]

    Garite TJ, Kurtzman J, Maurel K, Clark R. Obstetrix Collaborative Research Network. Impact of a ‘rescue course’ of antenatal corticosteroids: a multicenter randomized placebo-controlled trial. Am J Obstet Gynecol. 2009;200:248.e1–9.Google Scholar

  • [19]

    Makhija NK, Tronnes AA, Dunlap BS, Schulkin J, Lannon SM. Antenatal corticosteroid timing: accuracy after the introduction of a rescue course protocol. Am J Obstet Gynecol. 2016;214:120e1–6.Google Scholar

  • [20]

    Blickstein I, Shinwell ES, Lusky A, Reichman B. Israel Neonatal Network. Plurality-dependent risk of respiratory distress syndrome among very-low-birth-weight infants and antepartum corticosteroid treatment. Am J Obstet Gynecol. 2005;192:360–4.Google Scholar

  • [21]

    Choi SJ, Song SE, Seo ES, Oh SY, Kim JH, Roh CR. The effect of single or multiple courses of antenatal corticosteroid therapy on neonatal respiratory distress syndrome in singleton versus twin pregnancies. Aust NZ J Obstet Gynaecol. 2009;49:173–9.Google Scholar

  • [22]

    Blickstein I, Reichman B, Lusky A, Shinwell ES. Israel Neonatal Network. Plurality-dependent risk of severe intraventricular hemorrhage among very low birth weight infants and antepartum corticosteroid treatment. Am J Obstet Gynecol. 2006;194:1329–33.Google Scholar

  • [23]

    Gyamfi C, Mele L, Wapner RJ, Spong CY, Peaceman A, Sorokin Y, et al. The effect of plurality and obesity on betamethasone concentrations in women at risk for preterm delivery. Am J Obstet Gynecol. 2010;203:219.e1–5.Google Scholar

  • [24]

    Kuk JY, An JJ, Cha HH, Choi SJ, Vargas JE, Oh SY, et al. Optimal time interval between a single course of antenatal corticosteroids and delivery for reduction of respiratory distress syndrome in preterm twins. Am J Obstet Gynecol. 2013;209:256.e1–7.Google Scholar

  • [25]

    Bibbo C, Deluca L, Gibbs KA, Saltzman DH, Rebarber A, Green RS, et al. Rescue corticosteroids in twin pregnancies and short-term neonatal outcomes. Br J Obstet Gynaecol. 2013;120:58–63.Google Scholar

  • [26]

    Melamed N, Shah J, Soraisham A, Yoon EW, Lee SK, Shah PS, et al. Association between antenatal corticosteroid administration-to-birth interval and outcomes of preterm neonates. Obstet Gynecol. 2015;125:1377–84.Google Scholar

  • [27]

    Razaz N, Skoll A, Fahey J, Allen VM, Joseph KS. Trends in optimal, suboptimal, and questionably appropriate receipt of antenatal corticosteroid prophylaxis. Obstet Gynecol. 2015;125:288–96.Google Scholar

  • [28]

    Wilms FF, Vis JY, Pattinaja DA, Kuin RA, Stam MC, Reuvers JM, et al. Relationship between the time interval from antenatal corticosteroid administration until preterm birth and the occurrence of respiratory morbidity. Am J Obstet Gynecol. 2011;205:49.e1–7.Google Scholar

  • [29]

    Justus G, Sloboda DM, Henrich W, Plagemann A, Dudenhausen JW, Braun T. Avoiding the prenatal programming effects of glucocorticoids: are there alternative treatments for the induction of antenatal lung maturation? J Perinat Med. 2015;43:503–23.Google Scholar

  • [30]

    Liu G, Segrè J, Gülmezoglu A, Mathai M, Smith JM, Hermida J, et al. Antenatal corticosteroids for management of preterm birth: a multi-country analysis of health system bottlenecks and potential solutions. BMC Pregnancy Childbirth. 2015;15(Suppl 2):S3.Google Scholar

About the article

Corresponding author: Isaac Blickstein, MD, Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot 76100, Israel, Tel.: +972-545-201789


Published Online: 2016-04-06

Published in Print: 2017-01-01


The authors stated that there are no conflicts of interest regarding the publication of this article.


Citation Information: Journal of Perinatal Medicine, Volume 45, Issue 1, Pages 5–9, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm-2015-0405.

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