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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Konje, Justin C. / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica


IMPACT FACTOR 2018: 1.361
5-year IMPACT FACTOR: 1.578

CiteScore 2018: 1.29

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Source Normalized Impact per Paper (SNIP) 2018: 0.602

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1619-3997
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Volume 46, Issue 1

Issues

Uterine artery Doppler pulsatility index at 11–38 weeks in ICSI pregnancies with egg donation

Annalisa Inversetti
  • Department of Obstetrics and Gynecology, IRCCS Ospedale San Raffaele, Vita-Salute University, Milan, Italy
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/ Luca Mandia
  • Department of Obstetrics and Gynecology, Ospedale Luigi Sacco, University of Milano, Milan, Italy
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/ Massimo Candiani
  • Department of Obstetrics and Gynecology, IRCCS Ospedale San Raffaele, Vita-Salute University, Milan, Italy
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/ Irene Cetin
  • Department of Obstetrics and Gynecology, Ospedale Luigi Sacco, University of Milano, Milan, Italy
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/ Alessandro Larcher
  • Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Canada
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/ Valeria Savasi
  • Department of Obstetrics and Gynecology, Ospedale Luigi Sacco, University of Milano, Milan, Italy
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/ Enrico Papaleo
  • Department of Obstetrics and Gynecology, IRCCS Ospedale San Raffaele, Vita-Salute University, Milan, Italy
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/ Paolo Cavoretto
  • Corresponding author
  • Department of Obstetrics and Gynecology, IRCCS Ospedale San Raffaele, Vita-Salute University, Milan, Italy
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Published Online: 2017-02-10 | DOI: https://doi.org/10.1515/jpm-2016-0180

Abstract

Background:

Uterine artery Doppler pulsatility index (UtA-PI) may be different in pregnancies with egg donation (ICSI-ED) as compared to conceptions with autologous intra-cytoplasmatic sperm injection (autologous ICSI) and to spontaneous conceptions (SC).

Methods:

One hundred and ninety-four pregnant women with different modes of conception (MC) were prospectively evaluated: 53 ICSI-ED, 36 autologous ICSI and 105 SC. To evaluate the effects of different MC on PI, multivariable linear regression (MLR) models predicting UtA-PI were fitted after adjustment for maternal age, body mass index, race, parity, smoking status and gestational age.

Results:

In the first trimester, at MLR, autologous ICSI was not associated with a significantly different UtA-PI [estimate (EST) 0.01; 95% confidence interval (CI) −0.19, 0.2; P=0.9] when compared to SC. Conversely, MC by ICSI-ED was associated with lower first trimester UtA-PI (EST −0.32; CI −0.55, −0.08; P=0.01) when compared to SC. At MLR, MC by autologous ICSI and by ICSI-ED were not associated with significant differences in the second and third trimester UtA-PI when compared to SC.

Conclusion:

ICSI-ED conception presented lower UtA-PI when compared to SC at 11+0–13+6 weeks but not at later assessments. Correction of UtA-PI measurement specifying the origin of oocyte may be useful in first trimester screening.

Keywords: Egg donation (ED); intra-cytoplasmatic sperm injection (ICSI); in vitro fertilization (IVF); pulsatility index; uterine artery Doppler

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About the article

Corresponding author: Paolo Cavoretto, MD, PhD, Department of Obstetrics and Gynecology, IRCCS Ospedale San Raffaele, Vita-Salute University, Milan, Italy


Received: 2016-05-21

Accepted: 2017-01-12

Published Online: 2017-02-10

Published in Print: 2018-01-26


Author’s statement

Conflict of interest: Authors state no conflict of interest.

Material and methods: Informed consent: Informed consent has been obtained from all individuals included in this study.

Ethical approval: The research related to human subject use has complied with all the relevant national regulations, and institutional policies, and is in accordance with the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional review board or equivalent committee.


Citation Information: Journal of Perinatal Medicine, Volume 46, Issue 1, Pages 21–27, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm-2016-0180.

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