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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Konje, Justin C. / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica


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1619-3997
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Volume 46, Issue 1

Issues

Clinical characteristics and outcome of twin pregnancies complicated by single intrauterine death

Qiong Luo
  • Department of Obstetrics, Women’s Hospital, School of Medicine, Zhejiang University, 1st Xueshi Road, Hangzhou, China
  • Other articles by this author:
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/ Xiujun Han
  • Corresponding author
  • Department of Obstetrics, Women’s Hospital, School of Medicine, Zhejiang University, 1st Xueshi Road, Hangzhou, China
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2017-03-15 | DOI: https://doi.org/10.1515/jpm-2017-0008

Abstract:

Aim:

To investigate the clinical characteristics and outcome of twin pregnancies complicated by single intrauterine death and how to improve the outcomes of surviving twins. Three thousand three hundred and eighty-four women who delivered twin pregnancies at Women’s Hospital, Zhejiang University, School of Medicine were included. Clinical and demographic data on gestational age, etiology, morbidity and mortality for mothers and fetuses were collected.

Results:

The median gestational age for detecting a single intrauterine death in twin pregnancy was 29 weeks and the average gestational age of pregnancy termination was 32 weeks. At least one complication occurred in 93 of 134 mothers (69.4%). The leading causes of a single intrauterine death were umbilical cord abnormality (21.6%), congenital anomalies (17.9%), twin-twin transfusion syndrome (TTTS) (8.2%) and velamentous placenta (7.4%). Of the 134 cases, in 115 cases the remaining twin survived. The birth weight of the surviving twin was significantly higher in pregnancies that continued for more than 1 week after single intrauterine death compared to that ended within 1 week after intrauterine death.

Conclusions:

Extension of gestation for the surviving twin fetus as long as possible in ensuring the health of the surviving twin and mother, will improve the prognosis of surviving twin after a single intrauterine death.

Keywords: Clinical characteristics; complication; single intrauterine death; twin pregnancies; twin-twin transfusion syndrome (TTTS)

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About the article

Corresponding author: Xiujun Han, MD, Department of Obstetrics, Women’s Hospital, School of Medicine, Zhejiang University, 1st Xueshi Road, Hangzhou, China, Tel.: +86 571- 87061501, Fax: +86 571-87061878


Received: 2017-01-07

Accepted: 2017-02-09

Published Online: 2017-03-15

Published in Print: 2018-01-26


Author’s statement

Conflict of interest: Authors state no conflict of interest.

Material and methods: Informed consent: Informed consent has been obtained from all individuals included in this study.

Ethical approval: The research related to human subject use has complied with all the relevant national regulations, and institutional policies, and is in accordance with the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional review board or equivalent committee.

Funding: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: National Natural Science Foundation of China (No. 81571447), and Major Science and Technology Projects in Zhejiang Province (2012C13024-2).


Citation Information: Journal of Perinatal Medicine, Volume 46, Issue 1, Pages 75–79, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm-2017-0008.

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