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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Konje, Justin C. / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica

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5-year IMPACT FACTOR: 1.578

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Volume 47, Issue 7


Carboxyhemoglobin in umbilical cord blood and maternal smoking

Kevin Hengstler
  • Corresponding author
  • Jeroen Bosch Ziekenhuis, Henri Dunantstraat 1, 5223 GZ ’s-Hertogenbosch, The Netherlands, Tel.: 06-42 846781
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  • De Gruyter OnlineGoogle Scholar
/ Peter van ’t Sant / Petr E. Jira
Published Online: 2019-08-17 | DOI: https://doi.org/10.1515/jpm-2019-0004



Smoking during pregnancy still exists in daily life but the effect on the newborn in the early stage of life is still unclear. This study investigates the normal reference range of carboxyhemoglobin (HbCO) in umbilical cord blood gas (UBG).


A single center retrospective cross-sectional cohort study was performed with 1172 cases. We analyzed HbCO values in umbilical cord blood, maternal smoking, birth weight percentiles, duration of amenorrhea and maternal admission duration prior to delivery.


HbCO levels in newborns range from 0 to 7.7% with a mean of 0.6% (standard deviation 0.6). Newborns from women who smoked during pregnancy have a significant higher HbCO value compared to newborns from women who did not smoke. Birth weight is negatively correlated with HbCO (P = 0.001).


Our results show the normal reference range in this study is 0–1.2% for HbCO in the umbilical blood of newborns. Smoking prior to delivery leads to a higher HbCO value in the UBG sample of the newborn, a lower birth weight and may be potential harmful.

Keywords: carbon monoxide; carboxyhemoglobin; smoking; umbilical cord blood


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About the article

Received: 2019-01-04

Accepted: 2019-07-21

Published Online: 2019-08-17

Published in Print: 2019-09-25

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Citation Information: Journal of Perinatal Medicine, Volume 47, Issue 7, Pages 780–784, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm-2019-0004.

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