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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Konje, Justin C. / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica


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Volume 47, Issue 7

Issues

Pregnancy outcomes after thyroid cancer

Efrat Spiegel / Andrea R. Spence
  • Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, Montreal, QC, Canada
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Nicholas Czuzoj-Shulman
  • Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, Montreal, QC, Canada
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Haim Arie Abenhaim
  • Corresponding author
  • Jewish General Hospital, McGill University, Obstetrics and Gynecology, Montreal, Canada
  • Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, Montreal, QC, Canada
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2019-07-19 | DOI: https://doi.org/10.1515/jpm-2019-0039

Abstract

Background

Thyroid cancer is one of the most common cancers in women of reproductive age. Our purpose was to evaluate the association between thyroid cancer and maternal and neonatal outcomes of pregnancy.

Methods

We conducted a retrospective cohort study using the Healthcare Cost and Utilization Project, Nationwide Inpatient Sample (HCUP-NIS) database from the US. A cohort consisting of women who delivered between 1999 and 2014 was created. Multivariate logistic regression, controlling for baseline maternal characteristics, was used to compare pregnancy complications and neonatal outcomes of pregnant women with thyroid cancer [International Classification of Diseases, ninth edition (ICD-9) code 193] diagnosed before or during pregnancy with those of the obstetric population without thyroid cancer.

Results

The study included 14,513,587 pregnant women, of which 581 women had a diagnosis of thyroid cancer (4/100,000). During the observation period, there was an upward trend in the prevalence of thyroid cancer among pregnant women, though not statistically significant (P = 0.147). Women with thyroid cancer were more likely to be Caucasian, belong to a higher income quartile, have private insurance, to be discharged from an urban teaching hospital and to have pre-gestational hypertension. Women with thyroid cancer had a greater chance of delivering vaginally, requiring transfusion of blood and developing venous thromboembolism (VTE). Neonates of mothers with thyroid cancer were not found to be at increased risk for the adverse neonatal outcomes examined, specifically, congenital malformations, intrauterine growth restriction, fetal death and preterm labor.

Conclusion

Pregnancies complicated by thyroid cancer have higher incidences of VTE and need for transfusions, with comparable overall newborn outcomes.

Keywords: neonatal outcomes; pregnancy; pregnancy outcomes; thyroid cancer

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About the article

Received: 2018-10-16

Accepted: 2019-06-21

Published Online: 2019-07-19

Published in Print: 2019-09-25


Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Journal of Perinatal Medicine, Volume 47, Issue 7, Pages 710–716, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm-2019-0039.

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