Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Konje, Justin C. / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica


IMPACT FACTOR 2018: 1.361
5-year IMPACT FACTOR: 1.578

CiteScore 2018: 1.29

SCImago Journal Rank (SJR) 2018: 0.522
Source Normalized Impact per Paper (SNIP) 2018: 0.602

Online
ISSN
1619-3997
See all formats and pricing
More options …
Volume 47, Issue 7

Issues

Simultaneous analysis of bisphenol A fractions in maternal and fetal compartments in early second trimester of pregnancy

Monika Zbucka-Krętowska
  • Department of Reproduction and Gynaecological Endocrinology, Medical University of Bialystok, Marii Sklodowskiej-Curie 24a, 15-276 Bialystok, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Urszula Łazarek
  • Department of Pharmaceutical Analysis, Medical University of Bialystok, Mickiewicza 2D, 15-522 Bialystok, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Wojciech Miltyk
  • Department of Pharmaceutical Analysis, Medical University of Bialystok, Mickiewicza 2D, 15-522 Bialystok, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Iwona SidorkiewiczORCID iD: https://orcid.org/0000-0003-0254-3095 / Piotr Pierzyński
  • Department of Reproduction and Gynaecological Endocrinology, Medical University of Bialystok, Marii Sklodowskiej-Curie 24a, 15-276 Bialystok, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Robert Milewski
  • Department of Statistics and Medical Informatics, Medical University of Bialystok, Szpitalna 37, 15-295 Bialystok, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Sławomir Wołczyński
  • Department of Reproduction and Gynaecological Endocrinology, Medical University of Bialystok, Marii Sklodowskiej-Curie 24a, 15-276 Bialystok, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jan Czerniecki
  • Department of Biology and Pathology of Human Reproduction, Institute of Animal Reproduction and Food Research, Polish Academy of Science, Tuwima 10, 10-748 Olsztyn, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2019-07-26 | DOI: https://doi.org/10.1515/jpm-2019-0040

Abstract

Background

Bisphenol A (BPA) is an estrogenic, endocrine-disrupting compound widely used in the industry. It is also a ubiquitous environmental pollutant. Its presence was confirmed in human fetuses, which results from maternal exposure during pregnancy. The mechanisms behind maternal-fetal transfer, and relationships between pregnant women and fetal exposures remain unclear. The aim of this study was to assess the impact of maternal exposure to BPA on the exposure of the fetus.

Methods

Maternal plasma and amniotic fluid samples were collected from 52 pregnant women undergoing amniocentesis for prenatal diagnosis of chromosomal abnormalities. BPA was measured by gas chromatography-mass spectrometry (GC-MS). The permeability factor – a ratio of fetal-to-maternal BPA concentration – was used as a measure delineating the transplacental transfer of BPA.

Results

The median concentration of maternal plasma BPA was 8 times higher than the total BPA concentration in the amniotic fluid (8.69 ng/mL, range: 4.3 ng/mL–55.3 ng/mL vs. median 1.03 ng/mL, range: 0.3 ng/mL–10.1 ng/mL). There was no direct relationship between the levels of BPA in maternal plasma and amniotic fluid levels. The permeability factor, in turn, negatively correlated with fetal development (birth weight) (R = −0.54, P < 0.001).

Conclusion

Our results suggest that the risk of fetal BPA exposure depends on placental BPA permeability rather than the levels of maternal BPA plasma concentration and support general recommendations to become aware and avoid BPA-containing products.

Keywords: amniotic fluid; Bisphenol A; maternal plasma; prenatal exposure; second trimester

References

  • 1.

    Rochester JR. Bisphenol A and human health: a review of the literature. Reprod Toxicol 2013;42:132–55.Web of ScienceCrossrefGoogle Scholar

  • 2.

    Vandenberg LN, Hauser R, Marcus M, Olea N, Welshons WV. Human exposure to bisphenol A (BPA). Reprod Toxicol 2007;24:139–77.PubMedCrossrefWeb of ScienceGoogle Scholar

  • 3.

    Rhie YJ, Nam HK, Oh YJ, Kim HS, Lee KH. Influence of bottle-feeding on serum bisphenol a levels in infants. J Korean Med Sci 2014;29:261–4.CrossrefWeb of SciencePubMedGoogle Scholar

  • 4.

    Alonso-Magdalena P, Ropero AB, Soriano S, García-Arévalo M, Ripoll C, Fuentes E, et al. Bisphenol-A acts as a potent estrogen via non-classical estrogen triggered pathways. Mol Cell Endocrinol 2012;355:201–7.CrossrefWeb of SciencePubMedGoogle Scholar

  • 5.

    Di Renzo GC, Conry JA, Blake J, DeFrancesco MS, DeNicola N, Martin JN, et al. International Federation of Gynecology and Obstetrics opinion on reproductive health impacts of exposure to toxic environmental chemicals. Int J Gynaecol Obstet 2015;131:219–25.PubMedCrossrefGoogle Scholar

  • 6.

    Rubin BS. Bisphenol A: an endocrine disruptor with widespread exposure and multiple effects. J Steroid Biochem Mol Biol 2011;127:2–34.Web of ScienceGoogle Scholar

  • 7.

    Jornayvaz FR, Vollenweider P, Bochud M, Mooser V, Waeber G, Marques-Vidal P. Low birth weight leads to obesity, diabetes and increased leptin levels in adults: the CoLaus study. Cardiovasc Diabetol 2016;15:73.CrossrefPubMedWeb of ScienceGoogle Scholar

  • 8.

    Ciborowski M, Zbucka-Kretowska M, Bomba-Opon D, Wielgos M, Brawura-Biskupski-Samaha R, Pierzynski P, et al. Potential first trimester metabolomic biomarkers of abnormal birth weight in healthy pregnancies. Prenat Diagn 2014;34:870–7.Web of SciencePubMedCrossrefGoogle Scholar

  • 9.

    Lea RG, Amezaga MR, Loup B, Mandon-Pépin B, Stefansdottir A, Filis P, et al. The fetal ovary exhibits temporal sensitivity to a ’real-life’ mixture of environmental chemicals. Sci Rep 2016;6:22279.Web of ScienceCrossrefGoogle Scholar

  • 10.

    Balakrishnan B, Henare K, Thorstensen EB, Ponnampalam AP, Mitchell MD. Transfer of bisphenol A across the human placenta. Am J Obstet Gynecol 2010;202:393.e1–7.Web of ScienceCrossrefGoogle Scholar

  • 11.

    Engel SM, Levy B, Liu Z, Kaplan D, Wolff MS. Xenobiotic phenols in early pregnancy amniotic fluid. Reprod Toxicol 2006;21:110–2.PubMedCrossrefGoogle Scholar

  • 12.

    Shekhar S, Sood S, Showkat S, Lite C, Chandrasekhar A, Vairamani M, et al. Detection of phenolic endocrine disrupting chemicals (EDCs) from maternal blood plasma and amniotic fluid in Indian population. Gen Comp Endocrinol 2017;241:100–7.CrossrefPubMedWeb of ScienceGoogle Scholar

  • 13.

    Yamada H, Furuta I, Kato EH, Kataoka S, Usuki Y, Kobashi G, et al. Maternal serum and amniotic fluid bisphenol A concentrations in the early second trimester. Reprod Toxicol 2002;16:735–9.CrossrefPubMedGoogle Scholar

  • 14.

    Komarowska MD, Hermanowicz A, Czyzewska U, Milewski R, Matuszczak E, Miltyk W, et al. Serum bisphenol A level in boys with cryptorchidism: a step to male infertility? Int J Endocrinol 2015;2015:973154.Web of SciencePubMedGoogle Scholar

  • 15.

    Golub MS, Wu KL, Kaufman FL, Li LH, Moran-Messen F, Zeise L, et al. Bisphenol A: developmental toxicity from early prenatal exposure. Birth Defects Res B Dev Reprod Toxicol 2010;89:441–66.PubMedCrossrefWeb of ScienceGoogle Scholar

  • 16.

    Gauderat G, Picard-Hagen N, Toutain PL, Corbel T, Viguié C, Puel S, et al. Bisphenol A glucuronide deconjugation is a determining factor of fetal exposure to bisphenol A. Environ Int 2016;86:52–9.CrossrefPubMedWeb of ScienceGoogle Scholar

  • 17.

    Boucher JG, Boudreau A, Ahmed S, Atlas E. In vitro effects of bisphenol A β-D-glucuronide (BPA-G) on adipogenesis in human and murine preadipocytes. Environ Health Perspect 2015;123:1287–93.Web of SciencePubMedCrossrefGoogle Scholar

  • 18.

    Geer LA, Pycke BF, Sherer DM, Abulafia O, Halden RU. Use of amniotic fluid for determining pregnancies at risk of preterm birth and for studying diseases of potential environmental etiology. Environ Res 2015;136:470–81.CrossrefPubMedWeb of ScienceGoogle Scholar

  • 19.

    VandeVoort CA, Gerona RR, Vom Saal FS, Tarantal AF, Hunt PA, Hillenweck A, et al. Maternal and fetal pharmacokinetics of oral radiolabeled and authentic bisphenol A in the rhesus monkey. PLoS One 2016;11:e0165410.CrossrefPubMedWeb of ScienceGoogle Scholar

  • 20.

    Behnia F, Peltier M, Getahun D, Watson C, Saade G, Menon R. High bisphenol A (BPA) concentration in the maternal, but not fetal, compartment increases the risk of spontaneous preterm delivery. J Matern Fetal Neonatal Med 2016;29:3583–9.Web of ScienceCrossrefPubMedGoogle Scholar

  • 21.

    Fukata H, Miyagawa H, Yamazaki N, Mori C. Comparison of elisa- and LC-MS-based methodologies for the exposure assessment of bisphenol A. Toxicol Mech Methods 2006;16:427–30.CrossrefPubMedGoogle Scholar

  • 22.

    Azzouz A, Rascón AJ, Ballesteros E. Determination of free and conjugated forms of endocrine-disrupting chemicals in human biological fluids by GC-MS. Bioanalysis 2016;8:1145–58.Web of ScienceCrossrefPubMedGoogle Scholar

  • 23.

    Troisi J, Mikelson C, Richards S, Symes S, Adair D, Zullo F, et al. Placental concentrations of bisphenol A and birth weight from births in the Southeastern U.S. Placenta 2014;35:947–52.Web of SciencePubMedCrossrefGoogle Scholar

  • 24.

    Palanza P, Nagel SC, Parmigiani S, Vom Saal FS. Perinatal exposure to endocrine disruptors: sex, timing and behavioral endpoints. Curr Opin Behav Sci 2016;7:69–75.CrossrefPubMedWeb of ScienceGoogle Scholar

  • 25.

    Pinney SE, Mesaros CA, Snyder NW, Busch CM, Xiao R, Aijaz S, et al. Second trimester amniotic fluid bisphenol A concentration is associated with decreased birth weight in term infants. Reprod Toxicol 2017;67:1–9.Web of SciencePubMedCrossrefGoogle Scholar

  • 26.

    Chou WC, Chen JL, Lin CF, Chen YC, Shih FC, Chuang CY. Biomonitoring of bisphenol A concentrations in maternal and umbilical cord blood in regard to birth outcomes and adipokine expression: a birth cohort study in Taiwan. Environ Health 2011;10:94.CrossrefPubMedWeb of ScienceGoogle Scholar

  • 27.

    Edlow AG, Chen M, Smith NA, Lu C, McElrath TF. Fetal bisphenol A exposure: concentration of conjugated and unconjugated bisphenol A in amniotic fluid in the second and third trimesters. Reprod Toxicol 2012;34:1–7.PubMedCrossrefWeb of ScienceGoogle Scholar

  • 28.

    Schönfelder G, Wittfoht W, Hopp H, Talsness CE, Paul M, Chahoud I. Parent bisphenol A accumulation in the human maternal-fetal-placental unit. Environ Health Perspect 2002;110:A703–7.PubMedCrossrefGoogle Scholar

  • 29.

    Corbel T, Gayrard V, Viguié C, Puel S, Lacroix MZ, Toutain PL, et al. Bisphenol A disposition in the sheep maternal-placental-fetal unit: mechanisms determining fetal internal exposure.Biol Reprod 2013;89:11.PubMedWeb of ScienceGoogle Scholar

  • 30.

    Corbel T, Perdu E, Gayrard V, Puel S, Lacroix MZ, Viguié C, et al. Conjugation and deconjugation reactions within the fetoplacental compartment in a sheep model: a key factor determining bisphenol A fetal exposure. Drug Metab Dispos 2015;43:467–76.CrossrefWeb of ScienceGoogle Scholar

  • 31.

    Ikezuki Y, Tsutsumi O, Takai Y, Kamei Y, Taketani Y. Determination of bisphenol A concentrations in human biological fluids reveals significant early prenatal exposure. Hum Reprod 2002;17:2839–41.PubMedCrossrefGoogle Scholar

  • 32.

    Corbel T, Gayrard V, Puel S, Lacroix MZ, Berrebi A, Gil S, et al. Bidirectional placental transfer of bisphenol A and its main metabolite, bisphenol A-glucuronide, in the isolated perfused human placenta. Reprod Toxicol 2014;47:51–8.PubMedWeb of ScienceCrossrefGoogle Scholar

  • 33.

    Cantonwine DE, Ferguson KK, Mukherjee B, McElrath TF, Meeker JD. Urinary bisphenol A levels during pregnancy and risk of preterm birth. Environ Health Perspect 2015;123:895–901.Web of SciencePubMedCrossrefGoogle Scholar

  • 34.

    Weinberger B, Vetrano AM, Archer FE, Marcella SW, Buckley B, Wartenberg D, et al. Effects of maternal exposure to phthalates and bisphenol A during pregnancy on gestational age. J Matern Fetal Neonatal Med 2014;27:323–7.CrossrefPubMedWeb of ScienceGoogle Scholar

About the article

Corresponding author: Iwona Sidorkiewicz, PhD, Clinical Research Centre, Medical University of Bialystok, Marii Sklodowskiej-Curie 24a, 15-276 Bialystok, Poland


Received: 2019-02-06

Accepted: 2019-07-07

Published Online: 2019-07-26

Published in Print: 2019-09-25


Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Journal of Perinatal Medicine, Volume 47, Issue 7, Pages 765–770, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm-2019-0040.

Export Citation

©2019 Walter de Gruyter GmbH, Berlin/Boston.Get Permission

Comments (0)

Please log in or register to comment.
Log in