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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, MD, FRCOG, Joachim W.

Ed. by Bancalari, Eduardo / Chappelle, Joseph / Chervenak, Frank A. / D'Addario , Vincenzo / Genc, Mehmet R. / Greenough, Anne / Grunebaum, Amos / Konje, Justin C. / Kurjak M.D., Asim / Romero, Roberto / Zalud, MD PhD, Ivica


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1619-3997
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Volume 47, Issue 8

Issues

Comparison of fetal cardiac functions between small-for-gestational age fetuses and late-onset growth-restricted fetuses

Başak Kaya / Ahmet Tayyar / Deniz Kanber Açar
  • Department of Maternal-Fetal Medicine, Health Sciences University, Bakırköy Dr. Sadi Konuk Education and Research Hospital, İstanbul, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Serdar Kaya
Published Online: 2019-08-06 | DOI: https://doi.org/10.1515/jpm-2019-0206

Abstract

Background

This study aimed to investigate fetal cardiac functions by spectral tissue Doppler imaging (s-TDI) in pregnancies complicated with late-onset fetal growth restriction (LO-FGR) and small-for-gestational age (SGA).

Methods

Forty pregnancies complicated with late-onset FGR and 40 pregnancies complicated with SGA between the 34th and 37th weeks of gestation were enrolled in this study. Forty gestational age-matched pregnant women with no obstetrics complication were randomly selected as a control group. Small fetuses were classified as fetal growth restriction or SGA according to estimated fetal weight (EFW), umbilical artery pulsatility index (PI), cerebroplacental ratio (CPR) and uterine artery PI. s-TDI measurements were obtained at the right atrioventricular valve annulus.

Results

SGA and LO-FGR fetuses had significantly lower A′ and S′ values, and higher E′/A′ ratio than the control group (P < 0.001). In comparison to controls, significantly prolonged isovolumetric contraction time (ICT′) and isovolumetric relaxation time (IRT′) and, significantly shortened ejection time (ET′) were observed in fetuses with SGA and LO-FGR. Increased myocardial performance index (MPI′) values were also found in fetuses with SGA and LO-FGR compared to controls.

Conclusion

The signs of cardiac dysfunction were observed both in fetuses with SGA and LO-FGR. The fetal cardiac function assessment with s-TDI could be a valuable method in the diagnosis of true growth restricted fetuses and in the management of these fetuses.

Keywords: fetal cardiac function; late-onset fetal growth restriction; small-for-gestational age; spectral tissue Doppler imaging

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About the article

Corresponding author: Başak Kaya, MD, Department of Maternal-Fetal Medicine, Istanbul Medipol University Hospital, TEM Avrupa Otoyolu Göztepe Çıkışı no: 1, Bağcılar, Istanbul 34214, Turkey


Received: 2019-06-07

Accepted: 2019-07-21

Published Online: 2019-08-06

Published in Print: 2019-10-25


Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Journal of Perinatal Medicine, Volume 47, Issue 8, Pages 879–884, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: https://doi.org/10.1515/jpm-2019-0206.

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