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Journal of Veterinary Research

formerly Bulletin of the Veterinary Institute in Pulawy

4 Issues per year


IMPACT FACTOR Bull Vet Inst Pulawy 2016: 0.462

CiteScore 2016: 0.46

SCImago Journal Rank (SJR) 2015: 0.230
Source Normalized Impact per Paper (SNIP) 2015: 0.383

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2450-8608
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Evaluation of susceptibility to antimycobacterial drugs in Mycobacterium tuberculosis complex strains isolated from cattle in Poland

Monika Krajewska-Wędzina / Anna Zabost
  • Department of Microbiology, National Tuberculosis and Lung Diseases Institute in Warsaw, 01-138 Warsaw, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ewa Augustynowicz-Kopeć
  • Department of Microbiology, National Tuberculosis and Lung Diseases Institute in Warsaw, 01-138 Warsaw, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Marcin Weiner
  • Department of Microbiology, National Veterinary Research Institute, 24-100 Pulawy, Poland
  • Pope John Paul II State School of Higher Education in Biala Podlaska, 21-500 Biała Podlaska, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Krzysztof Szulowski
Published Online: 2017-04-04 | DOI: https://doi.org/10.1515/jvetres-2017-0003

Abstract

Introduction: Tuberculosis is a highly infectious disease affecting humans and animals. It is caused by the Mycobacterium tuberculosis complex (MTBC) – Mycobacterium bovis and Mycobacterium caprae, which are aetiological factors of bovine tuberculosis (bTB). In Poland, the bTB eradication programme exists. Animals diagnosed with tuberculosis are in the majority of cases not treated, but removed from their herd and then sanitary slaughtered.

Material and Methods: In total, 134 MTBC strains isolated from cattle in Poland were subjected to microbiological analysis. The resistance phenotype was tested for first-line antimycobacterial drugs used in tuberculosis treatment in humans: streptomycin, isoniazid, rifampicin, ethambutol, and pyrazinamide. The strains were isolated from tissues collected post mortem, so the test for drug resistance fulfilled only epidemiological criterion.

Results: The analysis of drug-resistance of MTBC strains revealed that strains classified as M. bovis were susceptible to 4 antimycobacterial drugs: isoniazid, rifampicin, streptomycin, and ethambutol, and resistant to pyrazynamide. The strains classified as M. caprae were sensitive to all tested drugs.

Conclusion: The results indicate that despite enormously dynamic changes in mycobacterial phenotype, Polish strains of MTBC isolated from cattle have not acquired environmental resistance. The strains classified as M. bovis are characterised by natural resistance to pyrazinamide, which is typical for this species.

Keywords: cattle; bovine tuberculosis; Mycobacterium tuberculosis complex; antimycobacterial drugs; Poland

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About the article

Received: 2016-12-07

Accepted: 2017-03-08

Published Online: 2017-04-04

Published in Print: 2017-03-01


Citation Information: Journal of Veterinary Research, ISSN (Online) 2450-8608, DOI: https://doi.org/10.1515/jvetres-2017-0003.

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© 2017 Monika Krajewska-Wędzina et al., published by De Gruyter Open. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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