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Journal of Veterinary Research

formerly Bulletin of the Veterinary Institute in Pulawy

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IMPACT FACTOR Bull Vet Inst Pulawy 2016: 0.462

CiteScore 2016: 0.46

SCImago Journal Rank (SJR) 2015: 0.230
Source Normalized Impact per Paper (SNIP) 2015: 0.383

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2450-8608
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DON-induced changes in bone homeostasis in mink dams

Ewa Tomaszewska / Piotr Dobrowolski
  • Department of Comparative Anatomy and Anthropology, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Lublin, 20-033 Poland
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/ Siemowit Muszyński
  • Department of Physics, Faculty of Production Engineering, University of Life Sciences in Lublin, 20-950 Lublin, Poland
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/ Krzysztof Kostro
  • Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Production Engineering, University of Life Sciences in Lublin, 20-950 Lublin, Poland
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/ Iwona Taszkun
  • Sub-department of Clinical Diagnostics and Veterinary Dermatology, Department and Clinic of Internal Medicine, Faculty of Veterinary Medicine, Faculty of Production Engineering, University of Life Sciences in Lublin, 20-950 Lublin, Poland
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/ Andrzej Żmuda
  • Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Production Engineering, University of Life Sciences in Lublin, 20-950 Lublin, Poland
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/ Tomasz Blicharski
  • Chair and Department of Rehabilitation and Orthopaedics, Medical University in Lublin, 20-090 Lublin, Poland
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/ Monika Hułas-Stasiak
  • Department of Comparative Anatomy and Anthropology, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Lublin, 20-033 Poland
  • Other articles by this author:
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Published Online: 2017-09-19 | DOI: https://doi.org/10.1515/jvetres-2017-0047

Abstract

Introduction: The aim of the study was to investigate the mechanical and geometric properties as well as bone tissue and mineral density of long bones in mink dams exposed to deoxynivalenol (DON) since one day after mating, throughout gestation (ca. 46 d) and lactation to pelt harvesting. Material and Methods: Thirty clinically healthy multiparous minks (Neovison vison) of the standard dark brown type were used. After the mating, the minks were randomly assigned into two equal groups: nontreated control group and DON group fed wheat contaminated naturally with DON at a concentration of 1.1 mg·kg-1 of feed. Results: The final body weight and weight and length of the femur did not differ between the groups. However, DON contamination decreased mechanical endurance of the femur. Furthermore, DON reduced the mean relative wall thickness and vertical wall thickness of the femur, while vertical cortical index, midshaft volume, and cross-sectional moment of inertia increased. Finally, DON contamination did not alter bone tissue density, bone mineral density, or bone mineral content, but decreased the values of all investigated structural and material properties. Conclusion: DON at applied concentration probably intensified the process of endosteal resorption, which was the main reason for bone wall thinning and the weakening of the whole bone.

Keywords: mink; deoxynivalenol; bone; biomechanical parameters

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About the article

Received: 2017-05-06

Accepted: 2017-08-11

Published Online: 2017-09-19

Published in Print: 2017-09-26


Citation Information: Journal of Veterinary Research, Volume 61, Issue 3, Pages 357–362, ISSN (Online) 2450-8608, DOI: https://doi.org/10.1515/jvetres-2017-0047.

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© 2017. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0

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