Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Journal of Laboratory Medicine

Official Journal of the German Society of Clinical Chemistry and Laboratory Medicine

Editor-in-Chief: Schuff-Werner, Peter

Ed. by Ahmad-Nejad, Parviz / Bidlingmaier, Martin / Bietenbeck, Andreas / Conrad, Karsten / Findeisen, Peter / Fraunberger, Peter / Ghebremedhin, Beniam / Holdenrieder, Stefan / Kiehntopf, Michael / Klein, Hanns-Georg / Kohse, Klaus P. / Kratzsch, Jürgen / Luppa, Peter B. / Meyer, Alexander von / Nebe, Carl Thomas / Orth, Matthias / Röhrig-Herzog, Gabriele / Sack, Ulrich / Steimer, Werner / Weber, Thomas / Wieland, Eberhard / Winter, Christof / Zettl, Uwe K.


IMPACT FACTOR 2018: 0.389

CiteScore 2018: 0.22

SCImago Journal Rank (SJR) 2018: 0.156
Source Normalized Impact per Paper (SNIP) 2018: 0.089

Online
ISSN
2567-9449
See all formats and pricing
More options …
Volume 33, Issue 5

Issues

CYP2D6 and tamoxifen: pharmacogenetic reinvention of an established drug?1

Nicolas von Ahsen / Claudia Binder / Jürgen Brockmöller / Michael Oellerich
Published Online: 2009-09-25 | DOI: https://doi.org/10.1515/JLM.2009.048et

Abstract

The selective estrogen receptor modulator tamoxifen is approved for treatment of estrogen receptor-positive breast cancer in pre- and postmenopausal patients. The main active metabolite of tamoxifen is endoxifen, which has high affinity towards the receptor and reaches high plasma concentrations. Endoxifen results from cytochrome P450 enzyme CYP2D6 action. CYP2D6 is subject to genetic polymorphism, with a prevalence of enzyme deficiency of approximately 7% in most European populations. Enzyme deficiency is reliably predicted by genotyping of known CYP2D6 deficiency alleles. Poor metabolizers (homozygote carriers of deficiency alleles) exhibit lower endoxifen plasma concentrations. Retrospective analyses of tamoxifen study data according to CYP2D6 genotypes reveal a poorer oncological outcome for subjects with deficiency alleles in most studies (level 3 evidence). Data from randomized controlled studies (level 1 evidence) on the use of CYP2D6 typing for tamoxifen therapy are lacking. However, CYP2D6 genotyping before initiating tamoxifen therapy and avoidance of tamoxifen in postmenopausal women with a CYP2D6 enzyme deficiency seem warranted. Prescribing information does not list CYP2D6 status as a contraindication for tamoxifen. Pharmacological supression of hot flashes by comedication with CYP2D6 inhibitors (e.g., fluoxetine, paroxetine) must be avoided because such patients will become functional Poor metabolizers with lower endoxifen levels.

Keywords: breast cancer; CYP2D6; pharmacogenetics; tamoxifen

About the article

Correspondence: Nicolas von Ahsen, Prof. Dr. med., University Medicine Göttingen, Department of Clinical Chemistry, Robert-Koch-Str. 40, 37099 Göttingen, Germany Tel.: +49 (551) 39-6379 Fax: +49 (551) 39-12501


Published Online: 2009-09-25

Published in Print: 2009-09-01


Citation Information: LaboratoriumsMedizin, Volume 33, Issue 5, Pages -–-, ISSN (Online) 1439-0477, ISSN (Print) 0342-3026, DOI: https://doi.org/10.1515/JLM.2009.048et.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Gulsah Saydan Kanberoglu, Fatih Coldur, Cihan Topcu, and Osman Cubuk
IEEE Sensors Journal, 2015, Volume 15, Number 11, Page 6199

Comments (0)

Please log in or register to comment.
Log in