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Offizielles Organ der Deutschen Vereinten Gesellschaft für Klinische Chemie und Laboratoriumsmedizin e.V. (DGKL) und affiliiert mit der Österreichischen Gesellschaft für Laboratoriumsmedizin und Klinische Chemie (ÖGLMKC)

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Neutrophil gelatinase-associated lipocalin (NGAL) for acute kidney injury – the renal troponin?1

Michael Haase1 / Anja Haase-Fielitz1

1Charité – Universitätsmedizin Berlin, Campus Virchow-Klinikum, Medizinische Klinik m. S. Nephrologie und Internistische Intensivmedizin, Berlin, Deutschland

Correspondence: PD Dr. med. Michael Haase, Medizinische Klinik m. S. Nephrologie und Internistische Intensivmedizin, Charité – Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany Tel.: +49-(0)30-450-553232 Fax: +49-(0)30-450-553909

Citation Information: LaboratoriumsMedizin. Volume 34, Issue 2, Pages -–-, ISSN (Online) 1439-0477, ISSN (Print) 0342-3026, DOI: 10.1515/jlm.2010.012et, May 2010

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Acute kidney injury (AKI) is a frequent complication of hospitalized patients and associated with significantly increased morbidity and mortality. Probably, the delay in the diagnosis of AKI resulting from currently available renal function markers, such as serum creatinine contributes to the fact that to date, no simple, safe, and effective intervention to prevent or successfully treat AKI in the general patient population has been found. At the time of diagnosis of established AKI, irreversible organ damage might already have occurred. Neutrophil gelatinase-associated lipocalin (NGAL) is a protease-resistant polypeptide, which is released from the distal nephron in response to ischemic, toxic, or inflammatory insult to the kidney. Available data suggest NGAL to be an early and predictive biomarker for AKI. Novel renal biomarkers indicating cellular/tissue damage might guide patient-tailored earlier initiation of nephroprotection or withdrawal of nephrotoxins directed at improvement of outcomes in patients developing AKI.

Keywords: acute kidney injury; acute renal failure; biomarker; neutrophil gelatinase-associated lipocalin (NGAL)

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