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LaboratoriumsMedizin

Offizielles Organ der Deutschen Vereinten Gesellschaft für Klinische Chemie und Laboratoriumsmedizin e.V. (DGKL) und affiliiert mit der Österreichischen Gesellschaft für Laboratoriumsmedizin und Klinische Chemie (ÖGLMKC)

Editor-in-Chief: Schuff-Werner, Peter

Editorial Board Member: Ahmad-Nejad, Parviz / Bidlingmaier, Martin / Borucki, Katrin / Karsten, Conrad / Fraunberger, Peter / Ghebremedhin, Beniam / Holdenrieder, Stefan / Kiehntopf, Michael / Klein, Hanns-Georg / Klouche, Mariam / Kohse, Klaus P. / Kratzsch, Jürgen / Luppa, Peter B. / März, Winfried / Nebe, Carl Thomas / Orth, Matthias / Ruf, Andreas / Sack, Ulrich / Steimer, Werner / Weber, Bernard / Wieland, Eberhard / Zettl, Uwe K.

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1439-0477
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Volume 34, Issue 3 (May 2010)

Issues

Immunosuppressant drug monitoring – a routine undertaking?1

Christoph Seger
  • Institute of Medical and Chemical Laboratory Diagnostics (ZIMCL), University Hospital Innsbruck, Innsbruck, Austria
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Michael Vogeser
  • Institute of Medical and Chemical Laboratory Diagnostics (ZIMCL), University Hospital Innsbruck, Innsbruck, Austria
  • Institute of Clinical Chemistry, Hospital of the University of Munich, Munich, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2010-07-05 | DOI: https://doi.org/10.1515/jlm.2010.027et

Abstract

The quantitative assessment of immunosuppressant drug levels is still one of the most challenging therapeutic drug monitoring procedures in clinical routine. During the past years, several technical developments matured to usable methods. In addition to immunoassays, liquid chromatography-tandem mass spectrometry has become a key method in immunosuppressant therapeutic drug monitoring. This overview should aid in understanding the advantages and disadvantages of the various assays and methods. UK-NEQAS proficiency testing results are used for an inter-assay comparison approach.

Keywords: immunoassays; immunosuppressant drugs; liquid chromatography-tandem mass spectrometry (LC-MS/MS); proficiency testing; tandem mass spectrometry; therapeutic drug monitoring

About the article

Correspondence: Christoph Seger, PhD, Institute of Medical and Chemical Laboratory Diagnostics (ZIMCL), University Hospital Innsbruck, Innsbruck, Austria Tel.: +43 51250481155 Fax: +43 51250424088


Published Online: 2010-07-05

Published in Print: 2010-05-01


Citation Information: LaboratoriumsMedizin, ISSN (Online) 1439-0477, ISSN (Print) 0342-3026, DOI: https://doi.org/10.1515/jlm.2010.027et.

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