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Journal of Laboratory Medicine

Official Journal of the German Society of Clinical Chemistry and Laboratory Medicine

Editor-in-Chief: Schuff-Werner, Peter

Ed. by Ahmad-Nejad, Parviz / Bidlingmaier, Martin / Bietenbeck, Andreas / Conrad, Karsten / Findeisen, Peter / Fraunberger, Peter / Ghebremedhin, Beniam / Holdenrieder, Stefan / Kiehntopf, Michael / Klein, Hanns-Georg / Kohse, Klaus P. / Kratzsch, Jürgen / Luppa, Peter B. / Meyer, Alexander von / Nebe, Carl Thomas / Orth, Matthias / Röhrig-Herzog, Gabriele / Sack, Ulrich / Steimer, Werner / Weber, Thomas / Wieland, Eberhard / Winter, Christof / Zettl, Uwe K.

IMPACT FACTOR 2018: 0.389

CiteScore 2018: 0.22

SCImago Journal Rank (SJR) 2018: 0.156
Source Normalized Impact per Paper (SNIP) 2018: 0.089

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Volume 34, Issue 4


Kryptopyrrole, a forgotten but important diagnostic parameter?1

Jürgen Kinkeldei
  • Synlab Medizinisches Versorgungszentrum Leinfelden-Echterdingen, Leinfelden-Echterdingen, Germany
  • Other articles by this author:
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Published Online: 2010-12-17 | DOI: https://doi.org/10.1515/jlm.2010.039et


There were speculations in the 1960s and 1970s about a compound in human urine which was first named mauve factor and later falsely identified as kryptopyrrole before the correct chemical structure was established as hydroxyhemopyrrollactame. It was thought to be useful in distinguishing a schizophrenic subpopulation. In addition, with certain porphyrias an elevated amount should be found in urine. These speculations were finally disproved in the late 1970s. This substance has now reappeared as hemopyrrollactame and is claimed to produce a severe vitamin B6 and zinc deficiency leading to different illnesses. For testing the substance in urine, expensive and unnecessary laboratory evaluations are proposed as well as nutritional supplements to overcome the deficiency.

Keywords: hydroxyhemopyrrollactame; kryptopyrrole; urine; vitamin B6 deficiency; zinc deficiency

About the article

Correspondence: Dr. ing. Jürgen Kinkeldei, Synlab Medizinisches Versorgungszentrum Leinfelden-Echterdingen, Max-Lang-Straße 58, 70771 Leinfelden-Echterdingen, Germany Tel.: +49 711-90330 Fax: +49 711-9033160

Published Online: 2010-12-17

Published in Print:

Citation Information: LaboratoriumsMedizin, Volume 34, Issue 4, Pages -–-, ISSN (Online) 1439-0477, ISSN (Print) 0342-3026, DOI: https://doi.org/10.1515/jlm.2010.039et.

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