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LaboratoriumsMedizin - Journal of Laboratory Medicine

Offizielles Organ der Deutschen Vereinten Gesellschaft für Klinische Chemie und Laboratoriumsmedizin e.V. (DGKL) und affiliiert mit der Österreichischen Gesellschaft für Laboratoriumsmedizin und Klinische Chemie (ÖGLMKC)

Editor-in-Chief: Schuff-Werner, Peter

Editorial Board Member: Ahmad-Nejad, Parviz / Bidlingmaier, Martin / Borucki, Katrin / Karsten, Conrad / Fraunberger, Peter / Ghebremedhin, Beniam / Holdenrieder, Stefan / Kiehntopf, Michael / Klein, Hanns-Georg / Klouche, Mariam / Kohse, Klaus P. / Kratzsch, Jürgen / Luppa, Peter B. / März, Winfried / Nebe, Carl Thomas / Orth, Matthias / Ruf, Andreas / Sack, Ulrich / Steimer, Werner / Weber, Bernard / Wieland, Eberhard / Tumani, Hayrettin / Zettl, Uwe K.

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Volume 37, Issue 6 (Nov 2013)

Issues

Developments and insights into the analysis of the human microbiome

Entwicklungen und Erkenntnisse in der Analyse des humanen Mikrobioms

Ovidiu Rücker
  • Corresponding author
  • IMGM Laboratories GmbH, Martinsried, Germany
  • Email:
/ Alexandra Dangel
  • IMGM Laboratories GmbH, Martinsried, Germany
/ Hanns-Georg Klein
  • IMGM Laboratories GmbH, Martinsried, Germany
  • Center for Human Genetics and Laboratory Medicine Dr. Klein & Dr. Rost, Martinsried, Germany
Published Online: 2013-08-29 | DOI: https://doi.org/10.1515/labmed-2013-0018

Abstract

The intense research focused on the human microbiome during the last years has shed some light on this mostly uncharacterized part of the human body. The constantly improving sequencing technologies have additionally eased the process of collecting a large amount of genome data from metagenomics samples. Using these methods, large studies with sufficient number of subjects have started to reveal the implications of our microbiome in health and disease. Here, we present a review on the last developments of sequencing technology together with an overview on the findings in this fast-evolving field of science.

Zusammenfassung

In den letzten Jahren haben sich immer mehr wissenschaftliche Untersuchungen auf das humane Mikrobiom konzentriert, um diesen noch meist unbekannten Teil des menschlichen Körpers intensiver zu durchleuchten. Die konstante Verbesserung der verfügbaren Sequenziertechnologien hat weiterhin die Verfügbarkeit von großen Mengen an genomischen Daten deutlich erleichtert. Hiermit konnten große Studien mit einer genügend großen Anzahl an Probanden beginnen zu beschreiben, welche Auswirkungen unser Mikrobiom nicht nur in Verbindung mit Krankheiten sondern auch auf unseren gesunden Körper hat. In diesem Übersichtsartikel beschreiben wir die neuesten Entwicklungen in den Sequenziertechnologien zusammen mit einer Darstellung neuester Erkenntnisse aus diesem Forschungsbereich, welcher sich immer schneller entwickelt.

Reviewed publication: KleinH.-G.

Keywords: human metagenome; Illumina; metagenomics; next-generation sequencing (NGS); Roche; 16S rRNA; humanes Metagenom; Illumina; Metagenomik; next generation sequencing (NGS); Roche; 16S rRNA

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About the article

Correspondence: Dr. Ovidiu Rücker, IMGM Laboratories GmbH, Lochhamer Str. 29, 82152 Martinsried, Germany, Tel.: +49 89 89557840, Fax: +49 89 89557841, E-Mail:


Received: 2013-06-05

Accepted: 2013-07-22

Published Online: 2013-08-29

Published in Print: 2013-11-01


Citation Information: LaboratoriumsMedizin, ISSN (Online) 1439-0477, ISSN (Print) 0342-3026, DOI: https://doi.org/10.1515/labmed-2013-0018. Export Citation

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