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Journal of Laboratory Medicine

Official Journal of the German Society of Clinical Chemistry and Laboratory Medicine

Editor-in-Chief: Schuff-Werner, Peter

Ed. by Ahmad-Nejad, Parviz / Bidlingmaier, Martin / Bietenbeck, Andreas / Conrad, Karsten / Findeisen, Peter / Fraunberger, Peter / Ghebremedhin, Beniam / Holdenrieder, Stefan / Kiehntopf, Michael / Klein, Hanns-Georg / Kohse, Klaus P. / Kratzsch, Jürgen / Luppa, Peter B. / Meyer, Alexander von / Nebe, Carl Thomas / Orth, Matthias / Röhrig-Herzog, Gabriele / Sack, Ulrich / Steimer, Werner / Weber, Thomas / Wieland, Eberhard / Winter, Christof / Zettl, Uwe K.


IMPACT FACTOR 2018: 0.389

CiteScore 2018: 0.22

SCImago Journal Rank (SJR) 2018: 0.156
Source Normalized Impact per Paper (SNIP) 2018: 0.089

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Volume 40, Issue 3

Issues

Comparison of the novel Maglumi ferritin immunoluminometric assay with Beckman Coulter DxI 800 ferritin

Mariella Dipalo / Cecilia Gnocchi / Rosalia Aloe / Giuseppe LippiORCID iD: http://orcid.org/0000-0001-9523-9054
Published Online: 2016-02-27 | DOI: https://doi.org/10.1515/labmed-2016-0003

Abstract

Background: The demand for routine measurement of ferritin is constantly increasing in clinical laboratories due to the clinical value of this biomarker for diagnosing anemia. Therefore, this study was aimed to compare the newly commercialized Maglumi ferritin immunoluminometric assay with a validated commercial and fully automated technique.

Methods: The comparison study included 95 consecutive inpatient serum samples referred to the local laboratory for routine ferritin measurement. Serum was separated, divided in two paired aliquots and immediately analyzed with both Beckman Coulter DxI 800 and Maglumi 2000. Correlation was assessed with Deming fit and Spearman’s correlation, the mean bias was estimated with Bland-Altman plot. The concordance between methods was calculated as percentage agreement and κ coefficient.

Results: An excellent correlation was observed between Maglumi and DxI (r=0.997). The mean bias was 34 ng/mL and the strength of agreement between values obtained with Maglumi and DxI was 98% and 100% at the lower and upper limits of the reference range. The agreement was also 98% for diagnosing iron deficiency and 94% for diagnosing iron overload.

Conclusions: Maglumi immunoassay may be regarded as a suitable alternative for routine and fully-automated assessment of ferritin in clinical laboratories.

Keywords: anemia; ferritin; immunoassay; methods

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About the article

Correspondence: Prof. Giuseppe Lippi, Section of Clinical Biochemistry, University Hospital of Verona, Via delle Menegone, 37134 – Verona, Italy, E-Mail: ; .


Received: 2016-01-07

Accepted: 2016-02-03

Published Online: 2016-02-27

Published in Print: 2016-06-01


Citation Information: LaboratoriumsMedizin, Volume 40, Issue 3, Pages 221–223, ISSN (Online) 1439-0477, ISSN (Print) 0342-3026, DOI: https://doi.org/10.1515/labmed-2016-0003.

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