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Macedonian Veterinary Review

The Journal of the Faculty of Veterinary Medicine-Skopje at the Ss. Cyril and Methodius University in Skopje

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SCImago Journal Rank (SJR) 2015: 0.203
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Online
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1857-7415
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Comparative Study of the Pharmacokinetics of Inorganic and Organic Iron Compounds in Broiler Chickens

Dimitrichka Dimitrova
  • Corresponding author
  • Department of Pharmacology, Animal Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria
  • Email:
/ Anna Arnaudova-Matey
  • Department of Non-infectious Diseases and Pharmacology, Faculty of Veterinary Medicine, University of Forestry, Sofi a, Bulgaria
/ Petar Dilov
  • Department of Non-infectious Diseases and Pharmacology, Faculty of Veterinary Medicine, University of Forestry, Sofi a, Bulgaria
/ Geno Angelov
  • Department of Non-infectious Diseases and Pharmacology, Faculty of Veterinary Medicine, University of Forestry, Sofi a, Bulgaria
/ Tandju Mehmedov
  • Department of Non-infectious Diseases and Pharmacology, Faculty of Veterinary Medicine, University of Forestry, Sofi a, Bulgaria
/ Toni Todorov
  • Department of Non-infectious Diseases and Pharmacology, Faculty of Veterinary Medicine, University of Forestry, Sofi a, Bulgaria
/ Denka Kushvalieva
  • Medical Diagnostic Laboratory “Chemalab-2003”, Sofi a, Bulgaria
/ Dimitrina Nikolova
  • Medical Diagnostic Laboratory “Chemalab-2003”, Sofi a, Bulgaria
/ Valija Dilova
  • “Medica” Ltd., Sofia, Bulgaria
Published Online: 2015-11-18 | DOI: https://doi.org/10.14432/j.macvetrev.2014.01.008

Abstract

The pharmacokinetics of ferrous methionate and ferrous sulphate was investigated in broiler chickens after intravenous injection and crop intubation. The iron compounds were injected intravenously in v. brachialis. After a 20-day “wash-out” period the ferrous methionate and ferrous sulphate were administered again by an elastic silicone tube into the crop. The serum concentrations of the iron were determined using a bioanalyser. Two pharmacokinetic approaches were used - compartmental and non-compartmental analysis. After i.v. injection we found statistically significantly longer and better distribution of the iron contained in the ferrous methionate compared to the ferrous sulphate. The АUC0→∞ was statistically significantly higher in the ferrous methionate. In the alimentary tract of broiler chickens, ferrous methionate was absorbed more rapidly than ferrous sulfate. It was also distributed at a higher volume as compared to the ferrous sulfate

Keywords: pharmacokinetics; ferrous sulphate; ferrous methionate; chickens

References

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About the article

Received: 2013-10-21

Revised: 2013-12-12

Accepted: 2014-01-08

Published Online: 2015-11-18

Published in Print: 2014-03-01


Citation Information: Macedonian Veterinary Review, ISSN (Online) 1857-7415, DOI: https://doi.org/10.14432/j.macvetrev.2014.01.008. Export Citation

© 2015. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. (CC BY-NC-ND 4.0)

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