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Macedonian Veterinary Review

The Journal of the Faculty of Veterinary Medicine-Skopje at the Ss. Cyril and Methodius University in Skopje

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A Report of a Hepatozoon Canis Infection in a Dog with Transmissible Venereal Tumour

Namakkal Rajamanickam Senthil
  • Corresponding author
  • Centralised Clinical Laboratory Madras Veterinary College, Chennai - 600007, Tamil Nadu, India
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/ Subramanian Subapriya
  • Centralised Clinical Laboratory Madras Veterinary College, Chennai - 600007, Tamil Nadu, India
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/ Subbaiah Vairamuthu
  • Centralised Clinical Laboratory Madras Veterinary College, Chennai - 600007, Tamil Nadu, India
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Published Online: 2015-11-18 | DOI: https://doi.org/10.14432/j.macvetrev.2015.06.046

Abstract In the present study, a case of a Hepatozoan canis infection in a dog with a sexually transmissible venereal tumour is reported. Haematological examination revealed marked decrease in haemoglobin, PCV and RBC counts and the blood smear revealed rouleaux formation of RBC, hypochromasia, leptocytes and neutrophilia. Neutrophils were parasitized with both non-nucleated and stained nucleated forms of H. canis. Serum biochemistry results showed elevated levels of alkaline phosphatise, whereas blood urea nitrogen, creatinine, total protein, albumin and globulin were in the normal range.

Keywords: canine; transmissible venereal tumour; Hepatozoon canis


  • 1. Goldschmidt, M. H., Hendrick, M. J. (2002). Tumours of the skin and soft tissues. In: Meuton, D. J. (Ed.), 4th ed., Tumours in Domestic Animals. (pp. 45-118). Press, Iowa. Iowa State.Google Scholar

  • 2. Chu, R.M., Sun, T.J., Yang, H.Y., Wang, D.G., Liao, K.W., Chuang, T.F., Lin, C.H., Lee, W.C. (2001). Heat shock proteins in canine transmissible venereal tumor. Vet. Immunol Immunopathol. 82, 9-21. http://dx.doi.org/10.1016/S0165-2427(01)00327-0CrossrefGoogle Scholar

  • 3. Cohen D. (1985). The canine transmissible venereal tumor: A unique result of tumour progression. Adv Cancer Res. 43, 75-112. http://dx.doi.org/10.1016/s0065-230x(08)60943-4CrossrefGoogle Scholar

  • 4. Gavazza, A., Bizzeti, M., Papini, R. (2003). Observations on dogs found naturally infected with Hepatozoon canis in Italy. Rev. Méd. Vét. 154, 565-571.Google Scholar

  • 5. Baneth, G., Samish,M., Shkap, V., (2007). Life cycle of Hepatozoon canis (apicomplexa: adeleorina: hepatozoidae) in the tick Rhipicephalus sanguineus and domestic dog (Canis familiaris). J. Parasitol. 93 (2): 283-299. http://dx.doi.org/10.1645/GE-494R.1 PMid:17539411CrossrefWeb of ScienceGoogle Scholar

  • 6. Stettner, N., Brenner, O., Eilam, R., Harmelin, A. (2005). Pegylated liposomal doxorubicin as a chemotherapeutic agent for treatment of canine transmissible venereal tumor in murine models. J. Vet. Med. 67, 1133-1139. http://dx.doi.org/10.1292/jvms.67.1133CrossrefGoogle Scholar

  • 7. Stockmann, D., Ferrari, H.F., Andrade, A.L., Lopes, R.A., Cardoso, T.C., Luvizotto, M.C.R. (2011). Canine transmissible venereal tumors: Aspects related to programmed cell death. Braz J. Vet. Pathol. 4, 67-75.Google Scholar

  • 8. Oruc, E., Saglam, Y.S., Cengiz, M., Polat, B. (2011). Cytological diagnosis of breast metastasis of transmissible venereal tumor by fine needle aspiration and the treatment with vincristine sulphate in a dog. Ankara Üniv Vet Fak Derg. 6, 63-69.Google Scholar

  • 9. Kerr, M.G. (2002). Clinical biochemistry and haematology. In: (2nd Ed.), Veterinary Laboratory Medicine (pp.135-147). Blackwell Science Ltd, USA.Google Scholar

  • 10. Sarma, K., Mondal, D.B., Saravanan, M., Kumar, M., Mahendran, K. ( 2012). Haemato-biochemical changes in Hepatozoon canis infected dog before and after therapeutic management J. Vet. Parasitol. 26 (1): 35-38.Google Scholar

  • 11. Kose, A.M, Cizmeci, S.U, Aydin, I, Dinc, D.A, Maden, M., Kanat, O. (2013). Disseminated metastatic transmissible venereal tumour in a bitch Eurasian J .Vet. Sci. 29, 1, 053-057.Google Scholar

  • 12. Paramjit K., Deshmukh, S., Rajsukhbir, S., Bansal, B.K., Randhawa, C.S., Singla, L.D. (2012). Para-clinico-pathological observations of insidious incidence of canine hepatozoonosis from a mongrel dog: a case report. J .Parasit. Dis. 36(1): 135-138. http://dx.doi.org/10.1007/s12639-011-0092-x PMid:23543040 PMCid:PMC3284626CrossrefGoogle Scholar

  • 13. Ruiz, M.F., Zimmermann, R.N., Aguirre, F.O., Forti, M.S. (2013). Hepatozoon canis asociado a un tumor venéreo transmisible: singular hallazgo. Vet. Arg. 30, 306.Google Scholar

  • 14. Baneth, G., Weigler, B. (1997). Retrospective casecontrol study of hepatozoonosis in dogs in Israel. J. Vet. Intern. Med. 11, 365-370. http://dx.doi.org/10.1111/j.1939-1676.1997.tb00482.x PMid:9470163CrossrefGoogle Scholar

  • 15. Gondim, L. F. P., Kohayagawa, A., Alencar, N. X., Biondo, A. W., Takahira, R. F., Franco, S. R. V. (1998). Canine hepatozoonosis in Brazil: description of eight naturally occurring cases. Vet. Parasitol. 74, 319-323. http://dx.doi.org/10.1016/S0304-4017(96)01120-XCrossrefGoogle Scholar

  • 16. Marino, G., Gaglio, G., Zanghi, A. (2012). Clinicopathological study of canine transmissible venereal tumour in leishmaniotic dogs. J. Small Anim. Pract. 53, 323-327. http://dx.doi.org/10.1111/j.1748-5827.2012.01201.x PMid:22489831CrossrefWeb of ScienceGoogle Scholar

  • 17. Raghunath, M., Sudha Rani Chowdhary, Ch., Vidya Sagar, P., Ravi Kumar, P. (2015). Genital and extra genital TVT in a bitch- a case report. Sch J Agric Vet Sci. 2(1B): 61-62.Google Scholar

About the article

Received: 2015-03-17

Revised: 2015-06-03

Accepted: 2015-06-10

Published Online: 2015-11-18

Published in Print: 2015-10-01

Citation Information: Macedonian Veterinary Review, Volume 38, Issue 2, Pages 233–237, ISSN (Online) 1857-7415, DOI: https://doi.org/10.14432/j.macvetrev.2015.06.046.

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© 2015. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0

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