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Open Medicine

formerly Central European Journal of Medicine

Editor-in-Chief: Darzynkiewicz, Zbigniew

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Volume 1, Issue 4


Volume 10 (2015)

Sympathetic nervous system and neurotransmitters: their possible role in neuroimmunomodulation of multiple sclerosis and some other autoimmune diseases

Vladimir Markelov / Maxim Trushin
  • Laboratory of Molecular Pathogenesis, Kazan Institute of Biochemistry and Biophysics, P.O. Box 30, 420111, Kazan, Russia
  • Department of Genetics, Kazan State University, 420008, Kazan, Russia
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Published Online: 2006-09-26 | DOI: https://doi.org/10.2478/s11536-006-0031-x


Multiple sclerosis is still a disease without a cure. Although intensive research efforts have led to the development of drugs that modify the activity of the disease, most of them have various side effects and are expensive. At the same time it is becoming apparent that some remedies usually used to treat somatic and psychic disorders also have immunomodulating properties, and may help manage multiple sclerosis and other autoimmune diseases. We describe here the role of the sympathetic nervous system in the neuro-immune interaction in multiple sclerosis and other immune diseases with increased cellular immunity as well as neurochemical disturbances that take place in these disorders.

Keywords: Multiple sclerosis; neuroimmunomodulation; sympathetic nervous system; adrenoreceptor; neurotransmitter; autoimmune disease

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Published Online: 2006-09-26

Published in Print: 2006-12-01

Citation Information: Open Medicine, Volume 1, Issue 4, Pages 313–329, ISSN (Online) 2391-5463, DOI: https://doi.org/10.2478/s11536-006-0031-x.

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