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formerly Central European Journal of Medicine

Editor-in-Chief: Darzynkiewicz, Zbigniew

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Volume 2, Issue 4 (Dec 2007)

Issues

New alternatives for erythropoietin therapy in chronic renal failure

Irina Stoian
  • Department of Biochemistry, Faculty of Medicine, University of Medicine and Pharmacy “Carol Davila”, 050473, Bucharest, Romania
  • Email:
/ Bogdan Manolescu
  • Department of Biochemistry, Faculty of Medicine, University of Medicine and Pharmacy “Carol Davila”, 050473, Bucharest, Romania
  • Email:
/ Valeriu Atanasiu
  • Department of Biochemistry, Faculty of Medicine, University of Medicine and Pharmacy “Carol Davila”, 050473, Bucharest, Romania
  • Email:
/ Olivera Lupescu
  • Department of Thrauma and Ortopaedics, Faculty of Medicine, University of Medicine and Pharmacy “Carol Davila”, 050473, Bucharest, Romania
  • Email:
Published Online: 2007-12-01 | DOI: https://doi.org/10.2478/s11536-007-0038-y

Abstract

Erythropoietin (EPO) is one of the main cytokines involved in the regulation of erythropoiesis. The main site of EPO production are the kidneys. An altered EPO production leads to pathological conditions such as anemia and polycythaemia. Due to the progressive loss of renal peritubular cells, patients with chronic kidney disease (CKD) have low EPO plasma levels. This decreases erythron stimulation with the direct consequence of developing anemia. Before the introduction in the clinical practice of rHuEpo, in the late 1980s, the only solution for treating this type of anemia were blood transfusions and anabolic steroids. Even rHuEpo has proven to be safe and effective for treatment of anemias, there are some concerns about its cost, the need for frequent parenteral administration, and development of anti-EPO antibodies. These inconveniences prompted the search for novel erythropoiesis stimulating agents. Different strategies lead to isolation or chemical synthesis of such agents as darbepoetin alfa and EPO mimetics. In this review, we present some general aspects of EPO biology, with emphasis on chronic renal failure, and expose some of the alternatives to EPO used for anemia correction.

Keywords: Erythropoietin; darbepoetin; hematide; synthetic erythropoiesis protein; chronic kidney disease; hepcidin

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About the article

Published Online: 2007-12-01

Published in Print: 2007-12-01


Citation Information: Open Medicine, ISSN (Online) 2391-5463, DOI: https://doi.org/10.2478/s11536-007-0038-y. Export Citation

© 2007 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. (CC BY-NC-ND 3.0)

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