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Open Medicine

formerly Central European Journal of Medicine

Editor-in-Chief: Darzynkiewicz, Zbigniew

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Volume 4, Issue 3


Volume 10 (2015)

Does appendectomy increase the risk of colorectal adenocarcinoma?

Emre Ergul / Erdal Gozetlik
  • Diagnostic and Interventional Radiology Department, Ankara Oncology Teaching and Research Hospital, 06490, Bahcelievler, Ankara, Turkey
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Published Online: 2009-07-03 | DOI: https://doi.org/10.2478/s11536-009-0045-2


Colorectal cancer ranks third as the most common malignancy in the United States and represents the second leading cause of cancer-related mortality. The appendix is thought to have a productive effect against colorectal carcinoma by the immune function based on its association with substantial lymphatic tissue. But, an appendectomy is still the most commonly performed emergency surgical procedure. It is aimed to assess the association between colorectal cancer and appendicectomy. The medical records of 455 patients who received medical and/or surgical treatment with the diagnosis of colorectal carcinoma in two medical centers in a-five-year period were reviewed. The patients were divided into subgroups according to the colonic localization of the tumor, appendectomy status and their body mass indexes (BMI). In order to define independent predictors of colon adeno-cancer, multiple logistic regression analysis was used. Statistically significant variables according to the univariate statistics were selected as candidate variables for multiple logistic regression analysis. A p-value<0.05 was considered statistically significant. Out of 455 colorectal adenocarcinoma patients, 122 (26.81%) were in right colon adenocarcinoma (CA) group, 267 (56.68%) were in left CA group and 66 (14.5%) were in the rectum adenocarcinoma group. Appendectomy was found as the second highest risk factor in rectum and right colon adenocarcinoma. Being appendectomized increases the risk of rectum adenocarcinoma 3.232 times (95%CI: 1.670–6.254), left CA 2.537 times (95%CI: 1.544–4.168) and right CA 3.607 times (95%CI: 2.056–6.330). In the light of our findings, we suggest that being appendectomized might increase the risk of colorectal adenocarcinoma in sporadic cases.

Keywords: Adenocarcinoma; Appendectomy; Colorectal carcinoma; Rectum

  • [1] Cancer statistics 2004. In cancer facts and figures. Atlanta, American Cancer Society, 2004, p.11 Google Scholar

  • [2] Ergul E. Heredity and familial tendency of acute appendicitis. Scand J Surg 2007; 96: 290–292 Google Scholar

  • [3] Malla BK. A study on ‘Vermiform Appendix’—a caecal appendage in common laboratory mammals. Kathmandu Univ Med J (KUMJ). 2003; 1:272–275 Google Scholar

  • [4] Grobost O, Boutron MC, Arveux P, Bedenne L, Chatrenet P, Faivre J. Appendectomy, cholecystectomy, Cholelithiasis and colorectal cancer. A retrospective case control study at the Coted’Or. Gastroenterol Clin Biol 1991; 15: 594–599 Google Scholar

  • [5] Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55: 74–108 http://dx.doi.org/10.3322/canjclin.55.2.74CrossrefGoogle Scholar

  • [6] Sandler RS. Epidemiology and risk factors for colorectal cancer. Gastroenterol Clin North Am 1996; 25: 717–735 http://dx.doi.org/10.1016/S0889-8553(05)70271-5CrossrefGoogle Scholar

  • [7] Fuchs CS. Dietary and lifestyle influences on colorectal carcinogenesis. In Saltz LB (ed.): Colorectal Cancer: Multimodality Management. Totowa, NJ, Humana Pres, 2002, pp 47–64 Google Scholar

  • [8] Barb D, Williams CJ, Neuwirth AK, Mantzoros CS. Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence. Am J Clin Nutr 2007; 86: 858–866 Google Scholar

  • [9] Al-Saleh I, Arif J, El-Doush I, Al-Sanea N, Jabbar AA, Billedo G, Shinwari N, Mashhour A, Mohamed G. Carcinogen DNA adducts and the risk of colon cancer: case-control study. Biomarkers. 2008;13: 201–216 http://dx.doi.org/10.1080/13547500701775449CrossrefGoogle Scholar

  • [10] Montgomery SM. Smoking in adults and passive smoking in children are associated with acute appendicitis. Lancet 1999; 353:379 http://dx.doi.org/10.1016/S0140-6736(05)74951-5CrossrefGoogle Scholar

  • [11] Ergul E, Kusdemir A. Smoking and acute appendicitis. The Internet Journal of Surgery. 2008; 14(1) Google Scholar

  • [12] Randal Bollinger R, Barbas AS, Bush EL, Lin SS, Parker W. Biofilms in the large bowel suggest an apparent function of the human vermiform appendix. J Theor Biol. 2007; 249: 826–831 http://dx.doi.org/10.1016/j.jtbi.2007.08.032Web of ScienceCrossrefGoogle Scholar

  • [13] Corr SC, Gahan CC, Hill C. M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis. FEMS Immunol Med Microbiol. 2008; 52: 2–12 http://dx.doi.org/10.1111/j.1574-695X.2007.00359.xCrossrefWeb of ScienceGoogle Scholar

  • [14] Fan YK, Zhang CC. Appendectomy and cancer- an epidemiological evaluation. Zhonghua Zhong Liu Za Zhi 1986; 8: 121–214 Google Scholar

  • [15] Abeatici S, Raso AM, Locatelli L. Appendectomy and colo-rectal carcinoma. Clinico- statistical and experimental studies. Minerva Chir 1977; 32: 333–340 PubMedGoogle Scholar

About the article

Published Online: 2009-07-03

Published in Print: 2009-09-01

Citation Information: Open Medicine, Volume 4, Issue 3, Pages 315–319, ISSN (Online) 2391-5463, DOI: https://doi.org/10.2478/s11536-009-0045-2.

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© 2009 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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