Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Open Medicine

formerly Central European Journal of Medicine

Editor-in-Chief: Darzynkiewicz, Zbigniew

1 Issue per year


IMPACT FACTOR 2016 (Open Medicine): 0.294
IMPACT FACTOR 2016 (Central European Journal of Medicine): 0.116

CiteScore 2016: 0.28

SCImago Journal Rank (SJR) 2015: 0.140
Source Normalized Impact per Paper (SNIP) 2015: 0.154

Open Access
Online
ISSN
2391-5463
See all formats and pricing
More options …
Volume 5, Issue 6 (Dec 2010)

Issues

Hypovitaminosis D and cardiometabolic risk factors among non-obese youth

Nasser Al-Daghri / Omar Al-Attas / Majed Alokail / Khalid Alkharfy / Mansour Yousef / Hesham Nadhrah / Abdulaziz Al-Othman / Yousef Al-Saleh / Shaun Sabico / George Chrousos
  • Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Riyadh, Kingdom of Saudi Arabia
  • First Department of Pediatrics, Athens University Medical School, 11527, Athens, Greece
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2010-10-07 | DOI: https://doi.org/10.2478/s11536-010-0045-2

Abstract

Hypovitaminosis D and increased cardiometabolic risk have been well established in adults. This study aims to determine whether or not vitamin D also influences cardiometabolic risk in children and adolescents. To test this hypothesis, we recruited 186 boys (mean age 12.4 ± 3.7 years) and 114 girls (11.6 ± 3.7) in a cross-sectional observational study. Anthropometrics were obtained and morning fasting blood samples were collected. Serum glucose and lipid profile were determined using routine methods. Serum 25-hydroxyvitamin D was quantified using an enzyme-linked immunosorbent assay. In our population, approximately 10% of subjects had severe 25-hydroxyvitamin D deficiency (< 12.5 nmol/L), while 50% of the boys and 40% of the girls had mild vitamin D deficiency (12.5–24.9 nmol/L). Circulating 25-hydroxyvitamin D concentrations were inversely correlated with age, body mass index (BMI), blood pressure, waist and hip circumferences and serum triglyceride concentrations, and positively associated with HDL-cholesterol. Age and systolic blood pressure were significant predictors of 25-hydroxyvitamin D, explaining about 30% of the variance (p = 0.0005). In conclusion, significant associations between serum 25-hydroxyvitamin D and cardiometabolic parameters support promising cardioprotective benefits from vitamin D sufficiency at an early age. Follow-up with prospective clinical intervention studies are needed to validate this hypothesis.

Keywords: 25-Hydroxycholecalciferol; Hypovitaminosis D; Children

  • [1] Molina J.A., Heng B.H., Global trends in cardiology and cardiothoracic surgery — an opportunity or a threat?, Ann. Acad. Med. Singapore 2009, 38, 541–545 Google Scholar

  • [2] Al-Nozha M.M., Abdullah M., Arafah M.R., Khalil M.Z., Khan N.B., Al-Mazrou Y.Y., et al., Hypertension in Saudi Arabia, Saudi Med. J. 2007, 28,77–84 Google Scholar

  • [3] Al-Nozha M.M., Arafah M.R., Al-Maatouq M.A., Khalil M.Z., Khan N.B., Al-Marzouki K., et al., Hyperlipidemia in Saudi Arabia, Saudi Med. J. 2008, 29, 282–287 Google Scholar

  • [4] Al-Nozha M., Al-Khadra A., Arafah M.R., Al-Maatouq M.A., Khalil M.Z., Khan N.B., et al., Metabolic syndrome in Saudi Arabia, Saudi Med. J. 2005, 26, 1918–1925 Google Scholar

  • [5] El-Mouzan M.I., Al-Herbish A., Al-Salloum A.A., Al-Omar A.A., Qurachi M.M., Trends in the nutritional status of Saudi children, Saudi Med. J. 2008, 29, 884–887 PubMedGoogle Scholar

  • [6] Al-Hazzaa H.M., Prevalence of physical inactivity in Saudi Arabia: a brief review, East Mediterr. Health J. 2004, 10, 663–670 Google Scholar

  • [7] Bawazeer N., Al-Daghri N., Valsamakis G., Al-Rubeaan K., Valsamakis G, Sabico S., et al., Sleep duration and quality associated with obesity among Arab children, Obesity 2009, 17, 2251–2253 http://dx.doi.org/10.1038/oby.2009.169CrossrefGoogle Scholar

  • [8] Camhi S.M., Katzmarzyk P.T., Tracking of cardiometabolic risk factor clustering from childhood to adulthood, Int. J. Pediatr. Obes. 2009, 1–8 CrossrefGoogle Scholar

  • [9] Jiang S., Bao Y., Hou X., Fang O., Wang C., Pan J., et al., Serum C-reactive protein and risk of cardiovascular events in middle-aged and older Chinese population, Am. J. Cardiol. 2009, 103, 1727–1731 http://dx.doi.org/10.1016/j.amjcard.2009.02.028CrossrefGoogle Scholar

  • [10] Zhou J., Austin R.C., Contributions of hyperhomocysteinemia to atherosclerosis: Causal relationship and potential mechanisms, Biofactors 2009, 35, 120–129 http://dx.doi.org/10.1002/biof.17Web of ScienceCrossrefGoogle Scholar

  • [11] Mithal A., Wahl D.A., Bonjour J.P., Burckhardt P., Dawson-Hughes B., Eisman J.A., et al., Global vitamin D status and determinants of hypovitaminosis D, Osteoporosis Int. 2009, 20, 1807–1820 http://dx.doi.org/10.1007/s00198-009-0954-6Web of ScienceCrossrefGoogle Scholar

  • [12] Judd S.E., Tangpricha V., Vitamin D deficiency and risk of cardiovascular disease, Am. J. Med. Sci. 2009, 338, 40–44 http://dx.doi.org/10.1097/MAJ.0b013e3181aaee91CrossrefGoogle Scholar

  • [13] Forouhi N.G., Luan J., Cooper A., Boucher B.J., Wareham N.J., Baseline serum 25-hydroxy vitamin D is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990–2000, Diabetes 2008, 57, 2619–2625 http://dx.doi.org/10.2337/db08-0593Web of ScienceGoogle Scholar

  • [14] Moradzadeh K., Larijani B., Keshtar A., Hossein-Nezhad A., Rajabian R., Nabipour I., et al., Normative values of vitamin D among Iranian population: a population based study, Int. J. Osteoporosis Metabolic Disorders 2008, 1, 8–15 http://dx.doi.org/10.3923/ijom.2008.8.15CrossrefGoogle Scholar

  • [15] Rovner A.J., O’Brien K.O., Hypovitaminosis D among healthy children in the United States, Arch. Pediatr. Adolesc. Med. 2008, 162, 513–519 http://dx.doi.org/10.1001/archpedi.162.6.513CrossrefGoogle Scholar

  • [16] Bener A., Al-Ali M., Hoffman G.F., High prevalence of vitamin D deficiency in young children in a highly sunny humid country: a global health problem, Minerva Pediatr. 2009, 61, 15–22 Google Scholar

  • [17] Sedrani S.H., Elidrissy A.W., El Arabi K.M., Sunlight and vitamin D status in normal Saudi subjects, Am. J. Clin. Nutr. 1983, 38, 129–132 Google Scholar

  • [18] Al-Atawi M.S., Al-Alwan I.A., Al-Mutair A.N., Tanim H.M., Al-Jurayyan N.A., Epidemiology of nutritional rickets in children, Saudi J. Kidney Dis. Transpl. 2009, 20, 260–265 Google Scholar

  • [19] McCarty M.F., Poor vitamin D status may contribute to high risk for insulin resistance, obesity and cardiovascular disease in Asian Indians, Med. Hypotheses 2009, 72, 647–651 http://dx.doi.org/10.1016/j.mehy.2008.12.031CrossrefWeb of ScienceGoogle Scholar

  • [20] Nemerovski C.W., Dorsch M.P., Simpson R.U., Bone H.G., Aaronson K.D., Bleske B.E., Vitamin D and cardiovascular disease, Pharmacotherapy 2009, 29, 691–708 http://dx.doi.org/10.1592/phco.29.6.691CrossrefWeb of ScienceGoogle Scholar

  • [21] Matias P.J., Ferreira C., Jorge C., Borges M., Aires I., Amaral T., 25-Hydroxyvitamin D3, arterial calcifications and cardiovascular risk markers in haemodialysis patients, Nephrol. Dial. Transplant 2009, 24, 611–618 http://dx.doi.org/10.1093/ndt/gfn502CrossrefGoogle Scholar

  • [22] Alemzadeh R., Kichler J., Babar G., Calhoun M., Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity and season, Metabolism 2008, 57, 183–191 http://dx.doi.org/10.1016/j.metabol.2007.08.023CrossrefGoogle Scholar

  • [23] Gannage-Yared M.H., Chedid R., Khalife S., Azzi E., Zoghbi F., Halaby G., Vitamin D in relation to metabolic risk factors, insulin sensitivity and adiponectin in a young Middle-Eastern population, Eur. J. Endocrinol. 2009, 160, 965–971 http://dx.doi.org/10.1530/EJE-08-0952CrossrefGoogle Scholar

  • [24] Forman J.P., Giovannucci E., Holmes M.D., Bischoff-Ferrari H.A., Tworoger S.S., Willett W.C., et al., Plasma 25-hydroxyvitamin D levels and risk of incident hypertension, Hypertension 2007, 49, 1063–1069 http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.087288CrossrefGoogle Scholar

  • [25] Hsia J., Heiss G., Ren H., Allison M., Dolan N.C., Greenland P., et al., Calcium/vitamin D supplementation and cardiovascular events, Circulation 2007, 115, 846–854 http://dx.doi.org/10.1161/CIRCULATIONAHA.106.673491CrossrefGoogle Scholar

About the article

Published Online: 2010-10-07

Published in Print: 2010-12-01


Citation Information: Open Medicine, ISSN (Online) 2391-5463, DOI: https://doi.org/10.2478/s11536-010-0045-2.

Export Citation

© 2010 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
I.R. Dabbour, A.S. Jazar, and F.S. Azzeh
Pakistan Journal of Nutrition, 2016, Volume 15, Number 3, Page 203
[2]
Naji J Aljohani, Nasser M Al-Daghri, Omar S Al-Attas, Majed S Alokail, Khalid M Alkhrafy, Abdulaziz Al-Othman, Sobhy Yakout, Abdulaziz F Alkabba, Ahmed S Al-Ghamdi, Mussa Almalki, Badurudeen Mahmood Buhary, and Shaun Sabico
BMC Endocrine Disorders, 2013, Volume 13, Number 1
[3]
Omar S Al-Attas, Nasser M Al-Daghri, Majed S Alokail, Khalid M Alkharfy, Assim A Alfadda, Philip McTernan, Greg C Gibson, Shaun B Sabico, and George P Chrousos
BMC Medical Genetics, 2012, Volume 13, Number 1
[4]
Nasser M Al-Daghri, Khalid M Alkharfy, Abdulaziz Al-Othman, Emad El-Kholie, Osama Moharram, Majed S Alokail, Yousef Al-Saleh, Shaun Sabico, Sudhesh Kumar, and George P Chrousos
Cardiovascular Diabetology, 2012, Volume 11, Number 1, Page 85
[5]
Sara Al-Musharaf, Abdulaziz Al-Othman, Nasser M. Al-Daghri, Soundararajan Krishnaswamy, Deqa S. Yusuf, Khalid M. Alkharfy, Yousef Al-Saleh, Omar S. Al-Attas, Majed S. Alokail, Osama Moharram, Sobhy Yakout, Shaun Sabico, and George P. Chrousos
European Journal of Pediatrics, 2012, Volume 171, Number 7, Page 1081
[6]
Nasser M. Al-Daghri, Omar S. Al-Attas, Majed S. Alokail, Khalid M. Alkharfy, Emad El-Kholie, Mansour Yousef, Abdulaziz Al-Othman, Yousef Al-Saleh, Shaun Sabico, Sudhesh Kumar, and George P. Chrousos
Clinical Endocrinology, 2012, Volume 76, Number 3, Page 346
[7]
Nasser M. Al-Daghri, Khalid M. Alkharfy, Yousef Al-Saleh, Omar S. Al-Attas, Majed S. Alokail, Abdulaziz Al-Othman, Osama Moharram, Emad El-Kholie, Shaun Sabico, Sudhesh Kumar, and George P. Chrousos
Metabolism, 2012, Volume 61, Number 5, Page 661
[8]
Nasser M Al-Daghri, Omar S Al-Attas, Majed S Alokail, Khalid M Alkharfy, Mansour Yousef, Shaun Louie Sabico, and George P Chrousos
BMC Medicine, 2011, Volume 9, Number 1

Comments (0)

Please log in or register to comment.
Log in