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Open Medicine

formerly Central European Journal of Medicine

Editor-in-Chief: Darzynkiewicz, Zbigniew

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Volume 5, Issue 6 (Dec 2010)


Hypovitaminosis D and cardiometabolic risk factors among non-obese youth

Nasser Al-Daghri / Omar Al-Attas / Majed Alokail / Khalid Alkharfy / Mansour Yousef / Hesham Nadhrah / Abdulaziz Al-Othman / Yousef Al-Saleh / Shaun Sabico / George Chrousos
  • Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Riyadh, Kingdom of Saudi Arabia
  • First Department of Pediatrics, Athens University Medical School, 11527, Athens, Greece
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Published Online: 2010-10-07 | DOI: https://doi.org/10.2478/s11536-010-0045-2


Hypovitaminosis D and increased cardiometabolic risk have been well established in adults. This study aims to determine whether or not vitamin D also influences cardiometabolic risk in children and adolescents. To test this hypothesis, we recruited 186 boys (mean age 12.4 ± 3.7 years) and 114 girls (11.6 ± 3.7) in a cross-sectional observational study. Anthropometrics were obtained and morning fasting blood samples were collected. Serum glucose and lipid profile were determined using routine methods. Serum 25-hydroxyvitamin D was quantified using an enzyme-linked immunosorbent assay. In our population, approximately 10% of subjects had severe 25-hydroxyvitamin D deficiency (< 12.5 nmol/L), while 50% of the boys and 40% of the girls had mild vitamin D deficiency (12.5–24.9 nmol/L). Circulating 25-hydroxyvitamin D concentrations were inversely correlated with age, body mass index (BMI), blood pressure, waist and hip circumferences and serum triglyceride concentrations, and positively associated with HDL-cholesterol. Age and systolic blood pressure were significant predictors of 25-hydroxyvitamin D, explaining about 30% of the variance (p = 0.0005). In conclusion, significant associations between serum 25-hydroxyvitamin D and cardiometabolic parameters support promising cardioprotective benefits from vitamin D sufficiency at an early age. Follow-up with prospective clinical intervention studies are needed to validate this hypothesis.

Keywords: 25-Hydroxycholecalciferol; Hypovitaminosis D; Children

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About the article

Published Online: 2010-10-07

Published in Print: 2010-12-01

Citation Information: Open Medicine, ISSN (Online) 2391-5463, DOI: https://doi.org/10.2478/s11536-010-0045-2.

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© 2010 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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