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Open Medicine

formerly Central European Journal of Medicine

Editor-in-Chief: Darzynkiewicz, Zbigniew

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IMPACT FACTOR 2016 (Open Medicine): 0.294
IMPACT FACTOR 2016 (Central European Journal of Medicine): 0.116

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2391-5463
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Volume 6, Issue 2 (Apr 2011)

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Potential role of FRAX analysis in postmenopausal women with osteopenia

Aleksandar Dimić
  • Institute for Prevention, Treatment and Rehabilitation of Rheumatic and Cardiovascular Diseases “Niska Banja”, 18000, Nis, Serbia
  • Email:
/ Stojanovic Sonja
  • Institute for Prevention, Treatment and Rehabilitation of Rheumatic and Cardiovascular Diseases “Niska Banja”, 18000, Nis, Serbia
  • Email:
/ Nedovic Jovan
  • Institute for Prevention, Treatment and Rehabilitation of Rheumatic and Cardiovascular Diseases “Niska Banja”, 18000, Nis, Serbia
  • Email:
/ Stankovic Aleksandra
  • Institute for Prevention, Treatment and Rehabilitation of Rheumatic and Cardiovascular Diseases “Niska Banja”, 18000, Nis, Serbia
  • Email:
/ Stamenkovic Bojana
  • Institute for Prevention, Treatment and Rehabilitation of Rheumatic and Cardiovascular Diseases “Niska Banja”, 18000, Nis, Serbia
  • Email:
/ Milenkovic Sasa
  • Institute for Prevention, Treatment and Rehabilitation of Rheumatic and Cardiovascular Diseases “Niska Banja”, 18000, Nis, Serbia
  • Email:
/ Mitic Valentina
  • Institute for Prevention, Treatment and Rehabilitation of Rheumatic and Cardiovascular Diseases “Niska Banja”, 18000, Nis, Serbia
  • Email:
Published Online: 2011-02-17 | DOI: https://doi.org/10.2478/s11536-011-0002-8

Abstract

Early diagnosis of osteoporosis and estimation of subjects that are at high risk for fracture, is neccesary for osteoporosis treatment. Dual-energy X-ray absorptometry (DXA) is a modern method for bone mineral density (BMD) evaluation. However, along BMD, clinical risk factors may significantly influence fracture development. Therefore, FRAX algorithm was designed for the assessment of a ten-year risk for serious osteoporotic fractures (SOF), as well as hip fractures. In the current study, we tried to evaluate the possible lumbal spine and hip BMD influence on ten year risk for SOF and hip fractures and potential role of FRAX in predicting the therapy in postmenopausal women with osteopenia. We performed the study on 385 postmenopausal women. According to the DXA measurements, at the lumbal (L) spine (L1–L4) and hip (femor neck), patients were then classified as normal, osteopenic, or osteoporotic. BMD evaluation included the L spine and the hip (subgroup 1), and only on the L spine (subgroup 2). By filling up the FRAX questionnaire, a ten-year risk for SOF fracture and hip fracture was calculated. BMD evaluation, in complete patient’s group and in subgroup 1, resulted in the highest number of osteoporosis (61.04%, 48.08%, retrospectively), while ospeopenia was a main finding in subgroup 2. In the subgroup 1, a high risk for SOF and hip fracture was detected in 16.45% and with high risk for hip fracture in 11.38% subjects. In subgroup 2, only high risk for hip fracture was observed in 3.16% subjects, indicating the active medicament treatment. Simultaneously, correlation of BMD results with FRAX values for SOF and hip fracture, showed significant negative correlation (p<0.001). Obtained results showed significant role of femur neck BMD evaluation in predicting the future factors, which may, together with FRAX analysis, improve the therapy approach in postmenopausal women with ospeopenia.

Keywords: Osteporosis; Osteopenia; Postmenopausal women; FRAX analysis

  • [1] Dimic A. Dijagnostika i lečenje osteoporoze, Balneoklimatologia 2004; 28: 39–42

  • [2] Dennison E and Cooper C. Epydemiology of osteoporotic fractures; Horm Res, 2000; 54: 58–63 [Crossref]

  • [3] Sleath B, Chewning B, de Vellis BM, Weinberger M, de Vellis RF, Tudor G, Beard A. Communication about depression during rheumatoid arthritis patient visits. Arthritis Rheum. 2008; 59: 186–191 http://dx.doi.org/10.1002/art.23347 [Crossref]

  • [4] Kang HY, Yang KH, Kim YN, Moon SH, Choi WJ, Kang DR, Park SE. Incidence and mortality of hip fracture among the elderly population in South Korea: a population-based study using the national health insurance claims data. BMC Public Health. 2010; 10: 230 http://dx.doi.org/10.1186/1471-2458-10-230 [Crossref]

  • [5] Lespessailles E, Cotté FE, Roux C, Fardellone P, Mercier F, Gaudin AF. Prevalence and features of osteoporosis in the French general population: The Instant study. Joint Bone Spine 2009; 76: 394–400 http://dx.doi.org/10.1016/j.jbspin.2008.10.008 [Crossref] [Web of Science]

  • [6] Kanis JA, Brazier JE, Stevenson M, Calvert NW, Lloyd Jones M. Treatment of established osteoporosis: a systematic review and cost-utility analysis. Health Technol Assess 2002; 6: 1–146

  • [7] Kanis JA. Diagnosis of osteoporosis and assessment of fracture risk. Lancet 2002; 359: 1929–1936 http://dx.doi.org/10.1016/S0140-6736(02)08761-5 [Crossref]

  • [8] The National Osteoporosis Foundation (NOF) Clinician’s Guide to prevention and treatment of osteoporosis 2008. National Osteoporosis Foundation, Washington, DC

  • [9] Aleksandar Dimic, Dimitrije Jankovic, Irena Jankovic, Todorka Savic, Nevena Karanovic. The effects of one-year simvastatin therapy on women’s bone mineral density. Cent Eur J Med 2010; 5: 588–592 http://dx.doi.org/10.2478/s11536-010-1031-8 [Crossref]

  • [10] Raluca Pais, Remus Campean, Siao-Pin Simon, Calin R. Bolosiu, Laura Muntean, Horatiu D. Bolosiu. Accuracy of Quantitative Ultrasound Parameters in the Diagnosis of Osteoporosis. Cent Eur J Med 2010; 5: 478–485 http://dx.doi.org/10.2478/s11536-009-0076-8 [Web of Science] [Crossref]

  • [11] Trémollieres FA, Pouillès JM, Drewniak N, Laparra J, Ribot CA, Dargent-Molina P: Fracture risk prediction using BMD and clinical risk factors in early postmenopausal women: Sensitivity of the WHO FRAX tool, Journal of Bone and Mineral Research 2010; 5: 1002–1009 http://dx.doi.org/10.1002/jbmr.12 [Crossref]

  • [12] Trémollieres F, Cochet T, Cohade C, Pouillès JM, Ribot C. Fracture risk in early postmenopausal women assessed using FRAX. Joint Bone Spine. 2010; 77: 345–348 http://dx.doi.org/10.1016/j.jbspin.2010.04.012 [Web of Science] [Crossref]

  • [13] Szczepaniak IM, Dytfeld J, Michalak M, Gowin E, Horst-Sikorska W, Efficacy of densitometry and fracture risk assessment tool FRAX in making therapeutic decisions in osteoporosis-a study on female patients of university of medical sciences endocrinology outpatient clinic; Ginekol Pol. 2009; 80: 424–431

  • [14] Kanis JA, Johnell O, Oden A, Johansson H and McCloskey E. FRAX™ and the assessment of fracture probability in men and women from the UK. Osteoporos Int 2008; 19: 385–397 http://dx.doi.org/10.1007/s00198-007-0543-5 [Crossref]

  • [15] Ronald CH., Keibzak GM. Variance in 10-years Fracture Risk Calculated With and Without T-score in Select Subgroups of Normal and Osteoporotic Patients; Clinical Densitometry 2009; 12: 158–161 http://dx.doi.org/10.1016/j.jocd.2008.12.003 [Crossref] [Web of Science]

  • [16] Fujiwara S., Nakamura T., Orimo H., Hosoi T, Gorai I., Oden A., Johansson H., J. A. Kanis. Development and application of a Japanese model of the WHO fracture risk assessment tool (FRAX™); Osteoporos Int 2008; 19: 429–435 http://dx.doi.org/10.1007/s00198-007-0544-4 [Crossref]

  • [17] Crabtree N. J., Bebbington N. A, Chapman D. M., Wahid Y. S, Ayuk J, C. M. Boivin, Cooper M. S., Gittoes N. J. L. Impact of UK National Guidelines based on FRAX-comparison with current clinical practice; Clinical Endocrinology 2010; 4: 452–456 [Web of Science]

About the article

Published Online: 2011-02-17

Published in Print: 2011-04-01



Citation Information: Open Medicine, ISSN (Online) 2391-5463, DOI: https://doi.org/10.2478/s11536-011-0002-8. Export Citation

© 2011 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. (CC BY-NC-ND 3.0)

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