Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Open Medicine

formerly Central European Journal of Medicine

Editor-in-Chief: Darzynkiewicz, Zbigniew

1 Issue per year


IMPACT FACTOR 2016 (Open Medicine): 0.294
IMPACT FACTOR 2016 (Central European Journal of Medicine): 0.116

CiteScore 2017: 0.53

SCImago Journal Rank (SJR) 2017: 0.154
Source Normalized Impact per Paper (SNIP) 2017: 0.264

Open Access
Online
ISSN
2391-5463
See all formats and pricing
More options …
Volume 6, Issue 4

Issues

Volume 10 (2015)

Spontaneous Pneumomediastinum, Pneumopericardium and Pneumorrhachis as potential complications of 2009 pandemic influenza A (H1N1) virus infection in healthy children

Filomena Pierri / Antonio Chiaretti
  • Pediatric Intensive Care Unit — Gemelli Hospital, Catholic University Medical School of Rome, 00168, Rome, Italy
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Giuseppe Barone / Donato Rigante / Piero Valentini / Claudia Fantacci / Danilo Buonsenso / Riccardo Riccardi
Published Online: 2011-06-01 | DOI: https://doi.org/10.2478/s11536-011-0036-y

Abstract

We report on two cases of spontaneous pneumomediastinum and pneumopericardium, in one case associated with pneumorrhachis, occurring in two children suffering from the novel influenza H1N1 virus infection. At the admission both children presented with fever, violent dry cough, dyspnea and tachypnea. Radiological studies showed sizeable pneumomediastinum and pneumopericardium in both patients. One of the patients also a pneumorrachis. Children were initially treated by intravenous broad-spectrum antibiotics, antipyretics and a cough sedative. Oral Oseltamivir (60 mg twice daily for 5 days) was administered after the diagnosis of influenza A (H1N1) virus infection. Patients’ clinical condition quickly improved and children were discharged with a partial resolution of their radiological findings. Although these conditions are usually self-limiting and without respiratory or systemic consequences, their prompt recognition in children with H1N1 influenza virus infection is essential to establish fast and adequate therapy mainly related to the control of cough and the commencement of antiviral treatment.

Keywords: Influenza virus infection; Pneumomediastinum; Pneumopericardium; Pneumorrhachis

  • [1] Garten RJ, Davis CT, Russell CA, et al., Antigenic and genetic characteristics of swine-origin 2009 A (H1N1) influenza viruses circulating in humans. Science 2009; 325, 197–201 http://dx.doi.org/10.1126/science.1176225CrossrefWeb of ScienceGoogle Scholar

  • [2] Hasegawa M, Hashimoto K, Morozumi M et al., Spontaneous pneumomediastinum complicating pneumonia in children infected with 2009 pandemic influenza A (H1N1) v virus. Clin Microbiol Infect 2010;16, 195–199 http://dx.doi.org/10.1111/j.1469-0691.2009.03086.xWeb of ScienceCrossrefGoogle Scholar

  • [3] Thompson WW, Shay DK, Weintraub E, et al., Influenza-associated hospitalizations in the United States. JAMA 2004; 292, 1333–1340 http://dx.doi.org/10.1001/jama.292.11.1333CrossrefGoogle Scholar

  • [4] Centers for Disease Control. Hospitalized patients with novel influenza A (H1N1) virus infection-California, April–May 2009. MMWR Morb Mortal Wkly Rep 2009;58, 536–554 Google Scholar

  • [5] Ozdemir H, Kendirli T, Dinçaslan HU, et al. Spontaneous pneumomediastinum in a child due to 2009 pandemic influenza A (H1N1) virus. Turk J Pediatr 2010;52:648–651 Google Scholar

  • [6] Udupa S, Hameed T, Kovesi T. Pneumomediastinum and subcutaneous emphysema associated with pandemic (H1N1) influenza in three children. CMAJ 2011;183:220–222 Google Scholar

  • [7] Caceres M, Ali SZ, Braud R, et al., Spontaneous pneumomediastinum: a comparative study and review of the literature. Ann Thorac Surg 2008;86, 962–963 http://dx.doi.org/10.1016/j.athoracsur.2008.04.067CrossrefWeb of ScienceGoogle Scholar

  • [8] Chalumeau M, Le Clainche L, Sayeg N, et al., Spontaneous pneumomediastinum in children. Pediatr Pulmonol 2001;31:67–75 http://dx.doi.org/10.1002/1099-0496(200101)31:1<67::AID-PPUL1009>3.0.CO;2-JCrossrefGoogle Scholar

  • [9] Romero J, Izquierdo Hidalgo J, Macià Botejara E, et al., Spontaneous pneumopericardium in a patient with community-aquired pneumonia. Rev Esp Cardiol 2005, 58, 227–229 http://dx.doi.org/10.1157/13071898CrossrefGoogle Scholar

  • [10] Oertel MF, Korinth MC, Reinges MH, et al. Pathogenesis, diagnosis and management of pneumorrhachis. Eur Spine J 2006;15, 636–643 http://dx.doi.org/10.1007/s00586-006-0160-6CrossrefGoogle Scholar

  • [11] Aribas OK, Gormus N, Aydogdu Kiresi D. Epidural emphysema associated with primary spontaneous pneumothorax. Eur J Cardiothorac Surg 2001;20, 645–646 http://dx.doi.org/10.1016/S1010-7940(01)00851-XCrossrefGoogle Scholar

  • [12] Chiba Y, Kakuta H. Massive subcutaneous emphysema, pneumomediastinum, and spinal epidural emphysema as complications of violent coughing: a case report. Auris Nasus Larynx 1995;22, 205–208 PubMedCrossrefGoogle Scholar

  • [13] Tutor JD, Montgomery VL, Eid NS. A case of influenza virus bronchiolitis complicated by pneumomediastinum and subcutaneous emphysema. Pediatr Pulmonol 1995;19, 393–395. http://dx.doi.org/10.1002/ppul.1950190614CrossrefGoogle Scholar

  • [14] Shimizu T, Mochizuki H, Morikawa A. Effect of influenza A virus infection on acid-induced cough response in children with asthma. Eur Respir J 1997;10, 71–74 http://dx.doi.org/10.1183/09031936.97.10010071CrossrefGoogle Scholar

About the article

Published Online: 2011-06-01

Published in Print: 2011-08-01


Citation Information: Open Medicine, Volume 6, Issue 4, Pages 386–389, ISSN (Online) 2391-5463, DOI: https://doi.org/10.2478/s11536-011-0036-y.

Export Citation

© 2011 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

Comments (0)

Please log in or register to comment.
Log in