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Open Medicine

formerly Central European Journal of Medicine

Editor-in-Chief: Darzynkiewicz, Zbigniew

IMPACT FACTOR 2018: 1.221

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Volume 6, Issue 5


Volume 10 (2015)

Vitamin D deficiency is related to worse emotional state

Lina Lašaite
  • Institute of Endocrinology, Medical Academy of Lithuanian University of Health Sciences, Kaunas, LT-50009, Lithuania
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/ Ieva Gailyte
  • Institute of Endocrinology, Medical Academy of Lithuanian University of Health Sciences, Kaunas, LT-50009, Lithuania
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/ Paulius Puzinas / Romualdas Preikša
  • Institute of Endocrinology, Medical Academy of Lithuanian University of Health Sciences, Kaunas, LT-50009, Lithuania
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/ Gintautas Kazanavičius
  • Institute of Endocrinology, Medical Academy of Lithuanian University of Health Sciences, Kaunas, LT-50009, Lithuania
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Published Online: 2011-08-09 | DOI: https://doi.org/10.2478/s11536-011-0061-x


The aim was to evaluate vitamin D levels in young healthy Lithuanian males in winter and to find possible associations of vitamin D concentration to body composition, cognitive functioning, emotional state.

Subjects and Methods A total of 130 healthy males (age range, 18–26 years) were divided into the subgroups according to vitamin D concentration. The Profile of Mood States (POMS) questionnaire and Hospital Anxiety and Depression Scale were employed in the assessment of emotional state. Cognitive functioning was assessed by the Trail Making Test and the Digit Symbol Test of the Wechsler Adult Intelligence Scale.

Results The mean concentration of vitamin D for the entire sample was 13.0±5.3 ng/ml. Only 2 persons (1.6%) had the recommended vitamin D level. Nearly half (45.4%) of study participants had vitamin D deficiency. Lower concentrations were associated with a significantly higher score on the POMS confusion-bewilderment scale. A tendency toward a lower mean depression-dejection score in the participants with a sufficient vitamin D level was observed. Vitamin D concentration correlated positively with body mass index (BMI) and inversely with the confusion-bewilderment score.

In conclusion almost half of the young healthy males participating in the study were detected to have vitamin D deficiency in winter. Low vitamin D concentrations are associated with a worse emotional state.

Keywords: Vitamin D; Healthy young males; Body composition; Cognitive functioning; Emotional state

  • [1] McCann JC, Ames BN. Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? FASEB J, 2008, 22, 982–1001 http://dx.doi.org/10.1096/fj.07-9326revCrossrefWeb of ScienceGoogle Scholar

  • [2] Peterlik M, Cross HS. Vitamin D and calcium deficits predispose for multiple chronic diseases. Eur J Clin Invest, 2005, 35, 290–304 http://dx.doi.org/10.1111/j.1365-2362.2005.01487.xCrossrefGoogle Scholar

  • [3] Gannagè-Yared MH, Chedid R, Khalife S, Azzi E, Zoghbi F. Vitamin D in relation to metabolic risk factors, insulin sensitivity and adiponectin in young Middle-Eastern population. Eur J Endocrinol, 2009, 160, 965–971 http://dx.doi.org/10.1530/EJE-08-0952CrossrefGoogle Scholar

  • [4] Ernst B, Thurnheer M, Schmid SM, Wilms B, Schultes B. Seasonal variations in the deficiency of 25-hydroxyvitamin D(3) in mildly to extremely obese subjects. Obes Surg, 2009, 19, 180–183 http://dx.doi.org/10.1007/s11695-008-9636-2CrossrefWeb of ScienceGoogle Scholar

  • [5] Wilkins CH, Scheline YI, Roe CM, Birge SJ, Morris JC. Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults. Am J Geriatr Psychiatry, 2006, 14, 1032–1040 http://dx.doi.org/10.1097/01.JGP.0000240986.74642.7cCrossrefGoogle Scholar

  • [6] Oudshoorn C, Mattace-Raso FU, van der Velde N, Colin EM, van der Cammen J. Higher serum vitamin D3 levels are associated with better cognitive test performance in patients with Alzheimer’s disease. Dement Geriatr Cogn Disord, 2008, 25, 539–543 http://dx.doi.org/10.1159/000134382Google Scholar

  • [7] Berk M, Sanders KM, Pasco JA, Jacka FN, Williams LJ, Hayles AL, et al. Vitamin D deficiency may play a role in depression. Med Hypotheses, 2007, 69, 1316–1319 http://dx.doi.org/10.1016/j.mehy.2007.04.001Web of ScienceCrossrefGoogle Scholar

  • [8] Basaran S, Guzel R, Coskun-Benlidayi I, Guler-Uysal F. Vitamin D status: effects on quality of life in osteoporosis among Turkish women. Qual Life Res, 2007, 16, 1491–1499 http://dx.doi.org/10.1007/s11136-007-9257-6CrossrefGoogle Scholar

  • [9] McGrath J, Scragg R, Chant D, Eyles D, Burne T, Obradovic D. No association between serum 25-hydroxyvitamin D3 level and performance on psychometric test in NHANES III. Neuroepidemiology, 2007, 29, 49–54 http://dx.doi.org/10.1159/000108918Web of ScienceGoogle Scholar

  • [10] Hoogendijk WJ, Lips P, Dik MG, Deeg DJ, Beekman AT, Penninx BW. Depression is associated with decreased 25-hydroxyvitamin D and increased parathyroid hormone levels in older adults. Arch Gen Psychiatry, 2008, 65, 508–512 http://dx.doi.org/10.1001/archpsyc.65.5.508CrossrefGoogle Scholar

  • [11] Lansdowne AT, Provost SC. Vitamin D3 enhances mood in healthy subjects during winter. Psychopharmacology (Berl), 1998, 135, 319–323 http://dx.doi.org/10.1007/s002130050517Google Scholar

  • [12] Armstrong DJ, Meenagh GK, Bickle I, Lee AS, Curran ES, Finch MB. Vitamin D deficiency is associated with anxiety and depression in fibromyalgia. Clin Rheumatol, 2007, 26, 551–554 http://dx.doi.org/10.1007/s10067-006-0348-5CrossrefGoogle Scholar

  • [13] Sherman SS, Hollis BW, Tobin JD. Vitamin D status and related parameters in a healthy population: the effects of age, sex and season. J Clin Endocrinol Metab, 1990, 71, 405–413 http://dx.doi.org/10.1210/jcem-71-2-405CrossrefGoogle Scholar

  • [14] Budak N, Cicek B, Sahin H, Tutus A. Bone mineral density and serum 25-hydroxyvitamin D level: is there any difference according to the dressing style of the female university students. Int J Food Sci Nutr, 2004, 55, 569–575 http://dx.doi.org/10.1080/09637480400015869CrossrefGoogle Scholar

  • [15] Poduje S, Sjerobabski-Masnec I, Ozanić-Bulić S. Vitamin D — the true and the false about vitamin D. Coll Antropol, 2008, 32(Suppl 2), 159–162 Google Scholar

  • [16] Hintzpeter B, Mensink GB, Thierfelder W, Müller MJ, Schneidt-Navel C. Vitamin D status and health correlates among German adults. Eur J Clin Nutr, 2008, 62, 1079–1089 http://dx.doi.org/10.1038/sj.ejcn.1602825CrossrefGoogle Scholar

  • [17] Manicourt DH, Devogelaer JP. Urban tropospheric ozone increases the prevalence of vitamin D deficiency among Belgian postmenopausal women with outdoor activities during summer. J Clin Endocrinol Metab, 2008, 93, 3893–3899 http://dx.doi.org/10.1210/jc.2007-2663CrossrefWeb of ScienceGoogle Scholar

  • [18] Binkley N, Krueger D, Gemar D, Drezner MK. Correlation among 25-hydroxyvitamin D assays. J Clin Endocrinol Metab, 2008, 93, 1804–1808 http://dx.doi.org/10.1210/jc.2007-2340CrossrefGoogle Scholar

  • [19] Ginde AA, Mansbach JM, Camargo CA Jr. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med, 2009, 169, 384–390 http://dx.doi.org/10.1001/archinternmed.2008.560Web of ScienceCrossrefGoogle Scholar

  • [20] Saintonge S, Bang H, Gerber LM. Implications of a new definition of vitamin D deficiency in a multiracial US adolescent population: the National Health and Nutrition Examination Survey III. Pediatrics, 2009, 123, 797–803 http://dx.doi.org/10.1542/peds.2008-1195CrossrefWeb of ScienceGoogle Scholar

  • [21] Egan KM, Signorello LB, Munro HM, Hargraves MK, Hollis BW, Blot WJ. Vitamin D insufficiency among African-Americans in the southeastern United States: implications for cancer disparities (United States). Cancer Causes Control, 2008, 19, 527–535 http://dx.doi.org/10.1007/s10552-008-9115-zCrossrefWeb of ScienceGoogle Scholar

  • [22] Zargar AH, Ahmad S, Masoodi SR, Wani AI, Laway BA, Shah ZA. Vitamin D status in apparently healthy adults in Kashmir Valley of Indian subcontinent. Postgrad Med J, 2007, 83, 713–716 http://dx.doi.org/10.1136/pgmj.2007.059113Web of ScienceCrossrefGoogle Scholar

  • [23] Pèrez-Llamas F, Lòpez-Contreros MJ, Blanco MJ, Lòpez-Azorin F, Zamora S, Moreiras O. Seemingly paradoxical seasonal influence on vitamin D status in nursing-home elderly people from a Mediterranean area. Nutrition 2008, 24, 414–420 http://dx.doi.org/10.1016/j.nut.2008.01.006Web of ScienceCrossrefGoogle Scholar

  • [24] McNair O, Lorr M, Droppleman LF. EDITS Manual for the Profile of Mood States. San Diego (Calif.): Educational and Institutional Testing Service; 1992 Google Scholar

  • [25] Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand, 1983, 67, 361–370 http://dx.doi.org/10.1111/j.1600-0447.1983.tb09716.xCrossrefGoogle Scholar

  • [26] Retain RM. A research program of the psychological effects of brain lesions in human beings. In: Ellis (ed.), International Review of research in mental retardation. New York: England Medical Center, 1977 Google Scholar

  • [27] Wechsler D. WAIS-R Manual. New York: Psychological Corp. 1981 Google Scholar

  • [28] Bruyère O, Malaise O, Neuprez A, Collette J, Reginster JY. Prevalence of vitamin D inadequacy in European postmenopausal women. Curr Med Res Opin, 2007, 23, 1939–1944 http://dx.doi.org/10.1185/030079907X219562Web of ScienceCrossrefGoogle Scholar

  • [29] Kull MJr, Kallikorm R, Tamm A, Lember M. Seasonal variance of 25-(OH)vitamin D in the general population of Estonia, a Northern European country. BMC Public Health, 2009, 9, 22–30 http://dx.doi.org/10.1186/1471-2458-9-22CrossrefWeb of ScienceGoogle Scholar

  • [30] Burstad M, Alsaker E, Engelsen O, Aksnes L, Lund E. Vitamin D status of middle-aged women at 65–71 degrees N in relation to dietary intake and exposure to ultraviolet radiation. Public Health Nutr, 2004, 7, 327–335 Google Scholar

  • [31] Moschonis G, Tanagra S, Koutisikas K, Nikolaidou A, Androutsos O, Manios Y. Association between serum 25-hydroxyvitamin D levels and body composition in postmenopausal women: the Postmenopausal Health Study. Menopause, 2009, 16, 701–707 http://dx.doi.org/10.1097/gme.0b013e318199d5d5CrossrefGoogle Scholar

  • [32] Liel Y, Ulmer E, Shary J, Hollis BW, Bell NH. Low circulating vitamin D in obesity. Calcif Tissue Int, 1988, 43, 199–201 http://dx.doi.org/10.1007/BF02555135CrossrefGoogle Scholar

  • [33] Wortsman J, Matsuoka LY, Then TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr, 2000, 72, 690–693 Google Scholar

  • [34] Harris SS, Dawson-Hughes B. Reduced sun exposure does not explain the inverse association of 28-hydroxyvitamin D with percent body fat in older adults. J Clin Endocrinol Metab, 2007, 92, 3155–3157 http://dx.doi.org/10.1210/jc.2007-0722Web of ScienceCrossrefGoogle Scholar

  • [35] Jorde R, Waterloo K, Saleh F, Haug E, Svartberg J. Neuropsychological function in relation to serum parathyroid hormone and serum 25-hydroxyvitamin D levels. The Tromsø study. J Neurol, 2006, 253, 464–703 http://dx.doi.org/10.1007/s00415-005-0027-5CrossrefGoogle Scholar

  • [36] Cherniak EP, Troen BR, Florez HJ, Roos BA, Levis S. Some new food role of vitamin D in the mental health of older adults. Curr Psychiatry Rep, 2009, 11, 12–19 http://dx.doi.org/10.1007/s11920-009-0003-3CrossrefGoogle Scholar

  • [37] Buell JS, Dawson-Hughes B. Vitamin D and neurocognitive dysfunction: preventing “D”ecline? Mol Aspects Med, 2008, 29, 415–422 http://dx.doi.org/10.1016/j.mam.2008.05.001CrossrefWeb of ScienceGoogle Scholar

  • [38] Minasyan A, Keisala T, Lou YR, Kalueff AV, Touhimaa P. Neophobia, sensory and cognitive functions, and hedonic responses in vitamin D receptor mutant mice. J Steroid Biochem Mol Biol, 2007, 104, 274–280 http://dx.doi.org/10.1016/j.jsbmb.2007.03.032CrossrefWeb of ScienceGoogle Scholar

  • [39] Holvik K, Meyer HE, Søgaard AJ, Haug E, Falch JA. Pakistanis living in Oslo have lower serum 1,25-dihydroxyvitamin D levels but higher serum ionized calcium levels compared with ethnics Norwegians. The Oslo Health Study. BMC Endocrine Disorders, 2007, 7, 9–15 http://dx.doi.org/10.1186/1472-6823-7-9CrossrefGoogle Scholar

About the article

Published Online: 2011-08-09

Published in Print: 2011-10-01

Citation Information: Open Medicine, Volume 6, Issue 5, Pages 558–566, ISSN (Online) 2391-5463, DOI: https://doi.org/10.2478/s11536-011-0061-x.

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© 2011 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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