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Open Medicine

formerly Central European Journal of Medicine

Editor-in-Chief: Darzynkiewicz, Zbigniew


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Volume 6, Issue 5

Issues

Volume 10 (2015)

Genome-wide linkage scan of major depressive disorder in two Dagestan genetic isolates

Kazima Bulayeva / Todd Lencz / Stephen Glatt
  • Department of Psychiatry and Behavioral Sciences, Medical Genetics Research Center, SUNY Upstate Medical University, Syracuse, NY, 13210, USA
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/ Toru Takumi / Farida Gurgenova / Oleg Bulayev
Published Online: 2011-08-09 | DOI: https://doi.org/10.2478/s11536-011-0071-8

Abstract

We conducted a 10-cM genome-wide linkage scan in two extended pedigrees, ascertained from two diverse Dagestan genetic isolates with high aggregation of major depressive disorder (MDD) and suicides. Using genome wide multipoint parametric linkage analyses with short tandem repeat markers, we found two previously undetected genomic regions with significant linkage in isolate #6007 with LODs=3.1–3.4 at 2p13.2–p11.2 (and some signal in same region for #6008) and in 14q31.12–q32.13. We also obtained suggestive evidence for linkage with MDD at 9q33.3–q34.2 (#6008), 13q31.1–q31.2(#6007), 11p15(#6008), 17q25.3(#6007) and 19q13.31–q13.33 (#6008). Five regions (1p36.1–p35.2, 2p13.2–p11.2, 17q25.3, 18q22 and 22q12.3) demonstrated at least nominal linkage in both isolates’ pedigrees, while all other linkage regions demonstrated population-specific genetic heterogeneity.

Keywords: Major Depressive Disorder; Early onset; Genetic isolates; Multipoint linkage analysis; Cross-isolates mapping; Suicides committed

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About the article

Published Online: 2011-08-09

Published in Print: 2011-10-01


Citation Information: Open Medicine, Volume 6, Issue 5, Pages 616–624, ISSN (Online) 2391-5463, DOI: https://doi.org/10.2478/s11536-011-0071-8.

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© 2011 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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