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Open Medicine

formerly Central European Journal of Medicine

Editor-in-Chief: Darzynkiewicz, Zbigniew


IMPACT FACTOR 2018: 1.221

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Volume 6, Issue 5

Issues

Volume 10 (2015)

Hepatitis C virus genotypes in injecting drug users from Romania

Camelia Sultana
  • Chair of Virology, Carol Davila University of Medicine and Pharmacy, 8 Eroilor Sanitari Bvd, 020021, Bucharest, Romania
  • Emergent Diseases Department, Stefan S. Nicolau Institute of Virology, 285 Mihai Bravu Bvd, 030304, Bucharest, Romania
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Codruta Vagu
  • Emergent Diseases Department, Stefan S. Nicolau Institute of Virology, 285 Mihai Bravu Bvd, 030304, Bucharest, Romania
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Aura Temereanca
  • Chair of Virology, Carol Davila University of Medicine and Pharmacy, 8 Eroilor Sanitari Bvd, 020021, Bucharest, Romania
  • Emergent Diseases Department, Stefan S. Nicolau Institute of Virology, 285 Mihai Bravu Bvd, 030304, Bucharest, Romania
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Camelia Grancea
  • Emergent Diseases Department, Stefan S. Nicolau Institute of Virology, 285 Mihai Bravu Bvd, 030304, Bucharest, Romania
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Josefina Slobozeanu / Simona Ruta
  • Chair of Virology, Carol Davila University of Medicine and Pharmacy, 8 Eroilor Sanitari Bvd, 020021, Bucharest, Romania
  • Emergent Diseases Department, Stefan S. Nicolau Institute of Virology, 285 Mihai Bravu Bvd, 030304, Bucharest, Romania
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2011-08-09 | DOI: https://doi.org/10.2478/s11536-011-0073-6

Abstract

Due to the increasing number of infections related to injecting drug use, both the pattern of hepatitis C virus (HCV) transmission, and the circulating genotypes in Europe have changed. As there are little available data in this respect for Romania, the aim of our study was a preliminary analysis of the distribution of HCV genotypes circulating among injecting drug users (IDUs). Of the 45 IDUs evaluated (86.7% men, mean age − 27.6 ± 3.7 years, mean age at first drug use − 17.5 ± 3.9 years), 88.9% presented anti-HCV antibodies, with higher rates in those with an injecting history of more than 10 years; 57.8% of the subjects had detectable HCV viral load. Only 6.7% had markers of chronic hepatitis B infection, and none had anti-HIV antibodies. While HCV subtype 1b is still prevalent (in 50% of the viraemic subjects), other subtypes begin to emerge, especially in younger patients (1a — in 23.1%, 4 — in 11.5%, 3a — in 7.7% of the cases). These data indicate the possibility of major shifts in the distribution of the dominant subtype, underlining the need for close surveillance of HCV infections in IDUs, who can act as a bridging group toward the general population.

Keywords: HCV prevalence; Romania; Injecting drug users; HCV genotypes

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About the article

Published Online: 2011-08-09

Published in Print: 2011-10-01


Citation Information: Open Medicine, Volume 6, Issue 5, Pages 672–678, ISSN (Online) 2391-5463, DOI: https://doi.org/10.2478/s11536-011-0073-6.

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© 2011 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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