Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Open Medicine

formerly Central European Journal of Medicine

Editor-in-Chief: Darzynkiewicz, Zbigniew


IMPACT FACTOR 2018: 1.221

CiteScore 2018: 1.01

SCImago Journal Rank (SJR) 2018: 0.329
Source Normalized Impact per Paper (SNIP) 2018: 0.479

ICV 2017: 152.94

Open Access
Online
ISSN
2391-5463
See all formats and pricing
More options …
Volume 7, Issue 2

Issues

Volume 10 (2015)

Vaccination in children with cancer: a debate

Andrea Battista / Antonio Ruggiero / Paola Coccia / Roberta Arena / Giorgio Attinà / Riccardo Riccardi
Published Online: 2012-02-03 | DOI: https://doi.org/10.2478/s11536-011-0143-9

Abstract

Children with malignancy present an important alteration of the immune system functionality caused by the illness itself and by the therapy they undergo. Therefore, they are at high risk of contracting vaccine-preventable diseases and of developing important complications. Vaccinations represent valid devices against these infections but this condition involves two main problems: are vaccines safe in these patients? Are vaccines effective in these patients? The aim of this review is to discuss the principles of vaccination management in children with cancer.

Keywords: Vaccination; Children; Cancer; Immunosuppression

  • [1] Borella L., Webster R.G. The immunosuppressive effects of long-term combination chemotherapy in children with acute leukemia in remission, Cancer Res., 1971, 31, 420–426 Google Scholar

  • [2] Mackall C.L. T-cell immunodeficiency following cytotoxic anti-neoplastic therapy: A review, Stem Cell, 2000, 18, 10–18 http://dx.doi.org/10.1634/stemcells.18-1-10CrossrefGoogle Scholar

  • [3] Mackall C.L., Fleisher T.A., Brown M.R., Magrath I.T., Shad A.T., Horowitz M.E., et al., Lymphocyte depletion during treatment with intensive chemotherapy for cancer, Blood, 1994, 84, 2221–2228 Google Scholar

  • [4] Mustafa M.M., Buchanan G.R., Winick N.J., McCracken G.H., Tkaczewski I., Lipscomb M., et al., Immune recovery in children with malignancy after cessation of chemotherapy, J. Pediatr. Hematol. Oncol., 1998, 20, 451–457 http://dx.doi.org/10.1097/00043426-199809000-00008CrossrefGoogle Scholar

  • [5] Goyal S., Pai S.K., Kelkar R., Advani S.H. Hepatitis B vaccination in acute lymphoblastic leukemia, Leuk. Res., 1998, 22, 193–195 http://dx.doi.org/10.1016/S0145-2126(97)00155-0CrossrefGoogle Scholar

  • [6] Yetgin S., Tunç B., Koç A., Toksoy H.B., Ceyhan M., Kanra G. Two booster dose hepatitis B virus vaccination in patients with leukemia, Leuk. Res. 2001, 25, 647–649 http://dx.doi.org/10.1016/S0145-2126(00)00101-6CrossrefGoogle Scholar

  • [7] Katz J., Walter B.N., Bennetts G.A. Abnormal cellular and humoral immunity in childhood acute lymphoblastic leukemia in long-term remission, West J. Med. 1987, 146, 179–187 Google Scholar

  • [8] Layward L., Levinsky R.J., Butler M. Long-term abnormalities in T and B lymphocyte function in children following treatment for acute lymphoblastic leukaemia, Br. J. Haematol. 1981, 49, 251–258 http://dx.doi.org/10.1111/j.1365-2141.1981.tb07221.xCrossrefGoogle Scholar

  • [9] National Institute of Allergy and Incfetious Diseases. 2011 available at: http://www.niaid.nih.gov/topics/vaccines/Pages/Default.aspx Google Scholar

  • [10] Smith S., Schiffman G., Karayalcin G., Bonagura V. Immunodeficiency in long-term survivors of acute lymphoblastic leukemia treated with Berlin-Frankfurt-Münster therapy, J. Pediatr. 1995, 127, 68–75 http://dx.doi.org/10.1016/S0022-3476(95)70259-8CrossrefGoogle Scholar

  • [11] Mitus A., Holloway A., Evans A.E., Enders J.F. Attenuated measles vaccine in children with acute leukemia, Am. J. Dis. Child 1962, 103, 413–418 Google Scholar

  • [12] American Academy of Pediatrics. Varicella-zoster infections. In: Pickering LK, Baker CJ, Kimberlin DW, et al editors (2009) Red Book: 2009 Report of the Committee on Infectious Diseases. Elk Grove Village, IL: American Academy of Pediatrics; pp714–727 Google Scholar

  • [13] Caniza M.A., et al., The controversy of varicella vaccination in children with acute lymphoblastic leukemia, Pediatr. Blood Cancer, 2010, (Epub ahead of print) Web of ScienceGoogle Scholar

  • [14] Sevinir B., Meral A., Günay U., Ozkan T., Ozuysal S., Sinirtas M. Increased risk of chronic hepatitis in children with cancer, Med. Pediatr. Oncol., 2003, 40, 104–110 http://dx.doi.org/10.1002/mpo.10090CrossrefGoogle Scholar

  • [15] O’Brien K.L., Swift A.J., Winkelstein J.A., Santosham M., Stover B., Luddy R., et al., Safety and immunogenicity of heptavalent pneumococcal vaccine conjugated to CRM(197) among infants with sickle cell disease. Pneumococcal Conjugate Vaccine Study Group, Pediatrics, 2000, 106, 965–972 Google Scholar

  • [16] American Academy of Pediatrics. In: Pickering LK, Baker CJ, Long SS, et al (2006) eds. Red Book: 2006 Report of the Committee on Infectious Diseases. 27th ed. Elk Grove Village, IL: American Academy of Pediatrics. Google Scholar

  • [17] Pinkerton R. Flu vaccination for children receiving or recently completing chemotherapy was effective, Arch. Dis. Child Educ. Pract. Ed 2010, 95, 198. Epub 2010 Nov 3 http://dx.doi.org/10.1136/adc.2010.192419CrossrefGoogle Scholar

  • [18] Donaldson S.S., Glatstein E., Vosti K.L. Bacterial infections in pediatric Hodgkin’s disease: relationship to radiotherapy, chemotherapy and splenectomy, Cancer, 1978, 41, 1949–1958 http://dx.doi.org/10.1002/1097-0142(197805)41:5<1949::AID-CNCR2820410539>3.0.CO;2-KCrossrefGoogle Scholar

  • [19] Esposito S., Cecinati V., Scicchitano B., Delvecchio G.C., Santoro N., Amato D., et al., Impact of influenza-like illness and effectiveness of influenza vaccination in oncohematological children who have completed cancer therapy, Vaccine, 2010, 10,28, 1558–1565. Epub 2009 Dec 8 http://dx.doi.org/10.1016/j.vaccine.2009.11.055CrossrefGoogle Scholar

  • [20] Allen U.D. Immunizations for children with cancer, Pediatr. Blood Cancer, 2007, 49, 1102–1108 http://dx.doi.org/10.1002/pbc.21346CrossrefGoogle Scholar

  • [21] Pollyea D.A., Brown J.M., Horning S.J. Utility of influenza vaccination for oncology patients, J. Clin. Oncol., 2010, 10,28, 2481–2490. Epub 2010 Apr 12 http://dx.doi.org/10.1200/JCO.2009.26.6908CrossrefGoogle Scholar

  • [22] Meral A., Sevinir B., Günay U. Efficacy of immunization against hepatitis B virus infection in children with cancer, Med. Pediatr. Oncol., 2000, 35, 47–51 http://dx.doi.org/10.1002/1096-911X(200007)35:1<47::AID-MPO8>3.0.CO;2-NCrossrefGoogle Scholar

  • [23] Haining WN, Neuberg DS, Keczkemethy HL, Evans JW, Rivoli S, Gelman R, et al., Antigen-specific T-cell memory is preserved in children treated for acute lymphoblastic leukemia. Blood 2005, 106, 1749–1754 http://dx.doi.org/10.1182/blood-2005-03-1082CrossrefGoogle Scholar

About the article

Published Online: 2012-02-03

Published in Print: 2012-04-01


Citation Information: Open Medicine, Volume 7, Issue 2, Pages 137–141, ISSN (Online) 2391-5463, DOI: https://doi.org/10.2478/s11536-011-0143-9.

Export Citation

© 2011 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

Comments (0)

Please log in or register to comment.
Log in