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Open Medicine

formerly Central European Journal of Medicine

Editor-in-Chief: Darzynkiewicz, Zbigniew

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Volume 7, Issue 4

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Volume 13 (2018)

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Volume 11 (2016)

Volume 10 (2015)

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Volume 6 (2011)

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Ventricular septal defects in function of maternal sociodemographic aspects

Attila Vereczkey / Zsolt Kósa / Melinda Csáky-Szunyogh / Róbert Urbán / Andrew Czeizel
Published Online: 2012-05-24 | DOI: https://doi.org/10.2478/s11536-012-0024-x

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Abstract

The objective of our project is to reveal the possible etiological factors of different congenital cardiovascular abnormalities. In this study, we evaluated single ventricular septal defect (VSD) after surgical correction or with lethal outcome. The birth outcomes of these cases in the function of maternal socio-demographic features were evaluated. Data are based on 1,659 VSD cases, 2,534 matched controls and 38,151 all controls without any defects, in addition in the mothers of 19,393 malformed controls with other isolated defects in the population-based large dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities. VSD had mild female excess with a higher rate of preterm birth and mainly low birth weight indicating intrauterine growth restriction of affected fetuses, particularly in males and full-term or average weighted cases. The mothers of cases with VSD had lower socioeconomic status and higher rate of smoking and particularly drinking habit. The evaluation of medically recorded pregnancy complications showed an association of gestational diabetes with a higher risk of VSD. In conclusion, the association of small localized size of VDS and obvious fetal growth restriction needs further explanation in these cases, while gestational diabetes, lower socioeconomic status and adverse lifestyle of pregnant women may have a role in the origin of VSD.

Keywords: Ventricular septal defect; Birth outcomes; Intrauterine growth restriction; Lower socioeconomic status; Alcohol drinking; Smoking; Gestational diabetes; Case-control population-based study

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About the article

Published Online: 2012-05-24

Published in Print: 2012-08-01

Citation Information: Open Medicine, Volume 7, Issue 4, Pages 511–522, ISSN (Online) 2391-5463, DOI: https://doi.org/10.2478/s11536-012-0024-x.

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© 2012 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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