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Open Medicine

formerly Central European Journal of Medicine

Editor-in-Chief: Darzynkiewicz, Zbigniew

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IMPACT FACTOR 2016 (Open Medicine): 0.294
IMPACT FACTOR 2016 (Central European Journal of Medicine): 0.116

CiteScore 2016: 0.28

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Source Normalized Impact per Paper (SNIP) 2015: 0.154

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Volume 8, Issue 2


Density of nerve fibres in eutopic endometrium in women with endometriosis

Ruta Liutkeviciene
  • Faculty of Medicine, Clinic of Obstetrics and Gynecology, Vilnius University, Antakalnio 57, Vilnius, Lithuania, LT-10207
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Zana Bumbuliene
  • Faculty of Medicine, Clinic of Obstetrics and Gynecology, Vilnius University, Antakalnio 57, Vilnius, Lithuania, LT-10207
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jolita Zakareviciene
  • Faculty of Medicine, Clinic of Obstetrics and Gynecology, Vilnius University, Antakalnio 57, Vilnius, Lithuania, LT-10207
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2013-01-23 | DOI: https://doi.org/10.2478/s11536-012-0122-9


Endometriosis is the disease which usually takes a wide range of time to be diagnosed. Recently, the investigators found that endometriosis could be diagnosed using the density of nerve fibers in eutopic endometrium after taking endometrium bioptate. The aim of the article is to summarize the existing literature on density of nerve fibers in eutopic endometrium in women with and without endometriosis. In this review were involved only those studies which used the same exclusion criteria and the same technology to detect nerve fibers in eutopic endometrium. Our review confirmed the position of all studies’ results that detection of specific nerve fibers within eutopic endometrium using minimally invasive endometrial biopsy technique could be widely used in clinical practice to diagnose endometriosis with high specificity and sensitivity.

Keywords: Endometriosis; Density of nerve fibers; Endometrial biopsy

  • [1] Chapron C., Fauconnier A., Dubuisson J.B., Barakat H., Vieira M., Bréart G., Deeply infiltrating endometriosis: relation between severity of dysmenorrhea and extent of the disease, Hum. Reprod., 2003, 18, 760–766 http://dx.doi.org/10.1093/humrep/deg152CrossrefGoogle Scholar

  • [2] Tokushige N., Merkham R., Russell P., Fraser I.S., High density of small nerve fibres in the functional layer of the endometrium in women with endometriosis, Hum. Reprod., 2006, 3, 782–787 Google Scholar

  • [3] Lebovic D.I., Mueller M.D., Taylor R.N., Immunobiology of endometriosis, Fertil. Steril., 2001, 75, 1–10 http://dx.doi.org/10.1016/S0015-0282(00)01630-7CrossrefGoogle Scholar

  • [4] Kyama C.M., Overbergh L., Debrock S., Valckx D., Vander Perre S., Meuleman C. et al., Increased peritoneal endometrial gene expression of biologically relevant cytokines and growth factors during the menstrual phase in women with endometriosis, Fertil. Steril., 2006, 85, 1667–1675 http://dx.doi.org/10.1016/j.fertnstert.2005.11.060CrossrefGoogle Scholar

  • [5] Tran L.V.P., Tokushige N., Berbic M., Markham R., Fraser I.S., Macrophages and nerve fibres in peritoneal endometriosis, Hum. Reprod., 2009, 4, 835–841 Web of ScienceGoogle Scholar

  • [6] Ballard K., Lowton K., Wright J., What’s the dalay? A qualitative study of women’s experiences of reaching a diagnosis of endomentriosis, Fertil. Steril., 2006, 86, 1296–301 http://dx.doi.org/10.1016/j.fertnstert.2006.04.054CrossrefGoogle Scholar

  • [7] Brosens I., Puttemans P., Campo R., Gordts S., Brosens J., Non-invasive methods of diagnosis of endometriosis, Curr. Opin. Obstet. Gynecol., 2003, 15, 519–522 http://dx.doi.org/10.1097/00001703-200312000-00011CrossrefGoogle Scholar

  • [8] Bokor A., Kyama C.M., Vercruysse L., Fassbender A., Gevaert O., Vodolazkaia A., De Moor B., Fülöp V., D’Hooghe T., Density of small diameter sensory nerve fibres in endometrium: a semi-invasive diagnostic test for minimal to mild endometriosis, Hum. Reprod., 2009,12, 3025–3032 http://dx.doi.org/10.1093/humrep/dep283CrossrefGoogle Scholar

  • [9] Al-Jefout M., Andreadis N., Tokushige N., Markham R., Fraser I., A pilot study to evaluate the relative efficacy of endometrial biopsy and full curettage in making a diagnosis of endometriosis by the detection of endometrial nerve fibres, Am. J. Obstet. Gynecol., 2007, 197, 578e1–578e4 http://dx.doi.org/10.1016/j.ajog.2007.04.032CrossrefWeb of ScienceGoogle Scholar

  • [10] Al-Jefout M., Dezarnaulds G., Cooper M., Tokushige N., Luscombe G.M., Markham R., Fraser I.S., Diagnosis of endometriosis by detection of nerve fibres in an endometrial biopsy: a double blind study, Hum. Reprod., 2009, 12, 3019–3024 http://dx.doi.org/10.1093/humrep/dep275CrossrefGoogle Scholar

  • [11] Meibody F.A., Kashi A.M., Mirzaie A.Z., Amam M.G.B., Behbahani A.S., Zolali B., Najafi L., Diagnosis of endometrial nerve fibres in women with endometriosis, Arch. Gynecol. Obstet., 2011, 284, 1157–1162 http://dx.doi.org/10.1007/s00404-010-1806-5CrossrefWeb of ScienceGoogle Scholar

  • [12] Makari S., Svedas E., Railaite R.D., Cizauskas A., Makari J., The value of nerve fibers in diagnosing endometriosis, Lithuanian Obstet and Gynecol., 2012, 2, 125–130 Google Scholar

  • [13] Melissa G., Medina & Dan I. Lebovic., Endometriosis-associated nerve fibers and pain, Obstet. Gynecol., 2009, 88, 968–975 Google Scholar

  • [14] Marcoux S., Maheux R., Berube S., Laparoscopic surgery in infertile women with minimal to mild endometriosis, Canadian Collaborative Group on Endometriosis. N Engl. J. Med., 1997, 337, 217–222 Google Scholar

About the article

Published Online: 2013-01-23

Published in Print: 2013-04-01

Citation Information: Open Medicine, Volume 8, Issue 2, Pages 141–145, ISSN (Online) 2391-5463, DOI: https://doi.org/10.2478/s11536-012-0122-9.

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© 2013 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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