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Open Medicine

formerly Central European Journal of Medicine

Editor-in-Chief: Darzynkiewicz, Zbigniew

IMPACT FACTOR 2018: 1.221

CiteScore 2018: 1.01

SCImago Journal Rank (SJR) 2018: 0.329
Source Normalized Impact per Paper (SNIP) 2018: 0.479

ICV 2018: 156.09

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Volume 8, Issue 3


Volume 10 (2015)

HLA antibody screening strategy in patients awaiting kidney transplantation

Svetlana Vojvodić
  • Tissue Typing Compartment, Department for laboratory testing, Institute for Blood Transfusion of Vojvodina, Hajduk Veljkova 9a, 21000, Novi Sad, Serbia
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  • Other articles by this author:
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/ Dušica Ademović-Sazdanić
  • Tissue Typing Compartment, Department for laboratory testing, Institute for Blood Transfusion of Vojvodina, Hajduk Veljkova 9a, 21000, Novi Sad, Serbia
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  • Other articles by this author:
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Published Online: 2013-04-17 | DOI: https://doi.org/10.2478/s11536-012-0073-1
  • [1] Slavcev A. Donor-specific antibodies and kidney transplant rejection. Annals of Transplantation 2003; 8(3):12–15 Google Scholar

  • [2] Muro M, Ljorenze S, Marin L, Moya-Quiles MR, et al. Acute vascular rejection mediated by HLA antibodies in a cadaveric kidney recipient: discrepancies between FlowPRATM, ELISA and CDC vs luminex screening. Nephrology Dialysis Transplantation 2005;20:223–226 http://dx.doi.org/10.1093/ndt/gfh527CrossrefGoogle Scholar

  • [3] Amico P, Honger G, Mayr M, Schaub S. Detection of HLA antibodies prior renal transplantation: prospects and limitations of new assays. Swiss Medical Weekly 2008; 138(33–34):472–476 Google Scholar

  • [4] Pelletier RP, Adams PW, Hennessy PK, Orosz CG. Comparison of crossmatch results obtained by ELISA, flow cytometry, and conventional methodologies. Humman Immunology 1999; 60(9):855–861 http://dx.doi.org/10.1016/S0198-8859(99)00072-5CrossrefGoogle Scholar

  • [5] Goggins R, Geiselhart L. Antibody screening beyond tears. ASHI Qarterly. Second Quarter 2003:70–72 Google Scholar

  • [6] Moise A, Nedelcu D, Toader A, Sora M, Tica A, Ferastraoaru DE, Constantinescu I. Cytotoxic antibodies — valuable prognostic factor for long term kidney allograft survival. Journal of Medicine and Life 2010; 3(4):390–395 Google Scholar

  • [7] Lucas DP, Paparounis ML, Myers L, Hart JM, et al. Detection of HLA class I-specific antibodies by the QuickScreen Enzyme-Linked Immunosorbent Assay. Clinical and Diagnostic Laboratory Immunology 1997; 4(3):252–257 Google Scholar

  • [8] Tait BD, Hudson F, Cantwell L, Brewin G, et al. Luminex technology for HLA antibody detection in organ transplantation. Nephrology 2009; 14:247–254 http://dx.doi.org/10.1111/j.1440-1797.2008.01074.xCrossrefWeb of ScienceGoogle Scholar

  • [9] Minucci PB, Grimaldi V, Casamassimi A, Cacciatore F, et al. Methodologies for Anti-HLA Antibody Screening in Patients Awaiting Kidney Transplant: A Comparative Study. Experimental and Clinical Transplantation 2011; 9(6):381–386 Google Scholar

  • [10] Lefaucheur C, Loupy A, Hill GS, Andrade J, et al. Preexisting Donor-Specific HLA Antibodies Predict Outcome in Kidney Transplantation. Journal of the American Society of Nephrology 2010;21:1398–1406 http://dx.doi.org/10.1681/ASN.2009101065CrossrefGoogle Scholar

  • [11] Altermann WW, Seliger B, Sel S, Wendt D, et al. Comparison of the established standard complement-dependent cytotoxicity and flow cytometric crossmatch assays with a novel ELISA-based HLA crossmatch procedure. Histology and Histopathology. 2006; 21:1115–1124 Google Scholar

  • [12] Schlaf G, Pollok-Kopp B, Manzke T, Schurat O et al. Novel solid phase-based ELISA assays contribute to an improved detection of anti-HLA antibodies and to an increased reliability of pre- and posttransplant crossmatching. Nephrology Dialysis Transplantation. 2010; 3:527–538 Google Scholar

  • [13] Puttarajappa C, Shapiro R, Tan HP. Antibody-Mediated Rejection in Kidney Transplantation: A Review. Journal of Transplantation. 2012:193724 Google Scholar

  • [14] Kissmeyer-Nielsen F, Olsen S, Petersen VP, Fjeldborg O. Hyperacute rejection of kidney allografts, associated with pre-existing humoral antibodies against donor cells. Lancet 1966; 2(7465):662–665. http://dx.doi.org/10.1016/S0140-6736(66)92829-7CrossrefGoogle Scholar

  • [15] Kao KJ, Scornik JC, Small SJ. Enzyme-linked immunoassay for anti-HLA antobodies — an alternative to panel studies by lymphocytotoxicity. Transplantation 1993; 55(1):192–196 http://dx.doi.org/10.1097/00007890-199301000-00036CrossrefGoogle Scholar

  • [16] Moore BA, Ploeger NA, DeGoey SR. HLA antibody screening: Comparison of a solid phase Enzyme-Linked Immunoassay with antiglobulin-augmented lymphocytotoxicity. Transplantation 1997; 64(11):1617–1620 http://dx.doi.org/10.1097/00007890-199712150-00023CrossrefGoogle Scholar

  • [17] Braun WE. Laboratory and clinical management of the highly sensitized organ transplant recipient. Humman Immunology 1989; 26(4):245–260 http://dx.doi.org/10.1016/0198-8859(89)90003-7CrossrefGoogle Scholar

  • [18] Kang E-S, Kim S-J, Choi KB, Chung KY. Continuous monitoring of donor specific anti-HLA antibody in kidney transplantation patients. The Journal of the Korean Society for Transplantation 2009; 23:227–232 http://dx.doi.org/10.4285/jkstn.2009.23.3.227CrossrefGoogle Scholar

  • [19] Slavcev A, Lacha J, Sajdlova H, Vitko Š, et al. Characterisation of patient antibodies after kidney transplantation. Annals of Transplantation 2001; 6(2):12–15 Google Scholar

  • [20] Tiercy JM, Cattin S, Pongratz G, Goumaz C, et al. A complementary strategy for pretransplant HLA antibody screening. Transplant Proceedings 2002; 34:850–851 http://dx.doi.org/10.1016/S0041-1345(02)02685-4CrossrefGoogle Scholar

  • [21] Worthington JE, Langton A, Liggett H, Robson AJ, et al. A novel strategy for the detection and definition of HLA-specific antibodies in patients awaiting renal transplantation. Transplant International 1998; Suppl 1:S372–S376 Google Scholar

  • [22] Fernandez-Fresnedo G, Pastor JM, Lopez-Hoyos M, Ruiz JC, et al. Relationship of donor-specific class-I anti-HLA antibodies detected by ELISA after kidney transplantation on the development of acute rejection and graft survival. Nephrology Dialysis Transplantation 2003; 18:990–995 http://dx.doi.org/10.1093/ndt/gfg068CrossrefGoogle Scholar

  • [23] Arnold ML, Zacher T, Dechant M, Kalden JR, et al. Detection and specification of noncomplement binding anti-HLA alloantibodies. Humman Immunology 2004; 65(11):1288–1296 http://dx.doi.org/10.1016/j.humimm.2004.08.182CrossrefGoogle Scholar

  • [24] Flesch B. Laboratory diagnostics of HLA antibodies. Laboratoriums Medizin 2003; 27(9–10):351–458 http://dx.doi.org/10.1046/j.1439-0477.2003.03067.xCrossrefGoogle Scholar

  • [25] Jaramillo A, Smith MA, Phelan D, Sundaresan S, et al. Development of ELISA-detected anti-HLA antibodies precedes the development of bronchiolitis obliterans syndrome and correlates with progresive decline in pulmonary function after lung transplantation. Transplantation 1999; 67(8):1155–1161 http://dx.doi.org/10.1097/00007890-199904270-00012CrossrefGoogle Scholar

About the article

Published Online: 2013-04-17

Published in Print: 2013-06-01

Citation Information: Open Medicine, Volume 8, Issue 3, Pages 317–321, ISSN (Online) 2391-5463, DOI: https://doi.org/10.2478/s11536-012-0073-1.

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© 2013 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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