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Open Medicine

formerly Central European Journal of Medicine

Editor-in-Chief: Darzynkiewicz, Zbigniew

IMPACT FACTOR 2018: 1.221

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Volume 8, Issue 3


Volume 10 (2015)

Urine saturation and promoter/inhibitor parameters and ratios in renal stone disease caused by ceftriaxone

Danko Milošević
  • Department for Pediatric Nephrology, University Children’s Hospital Zagreb, Zagreb School of Medicine, Kišpatićeva 12, 10000, Zagreb, Croatia
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/ Branko Miše / Ivan Habuš / Marija Topalović-Grković / Danica Batinić
  • Department for Pediatric Nephrology, University Children’s Hospital Zagreb, Zagreb School of Medicine, Kišpatićeva 12, 10000, Zagreb, Croatia
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/ Anja Golubić
  • Department for Pediatric Nephrology, University Children’s Hospital Zagreb, Zagreb School of Medicine, Kišpatićeva 12, 10000, Zagreb, Croatia
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/ Daniel Turudić
  • Department for Pediatric Nephrology, University Children’s Hospital Zagreb, Zagreb School of Medicine, Kišpatićeva 12, 10000, Zagreb, Croatia
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Published Online: 2013-04-17 | DOI: https://doi.org/10.2478/s11536-012-0091-z


During ceftriaxone treatment of subdural empyema caused by Streptococcus intermedius urinary and biliary stones were noticed. Increased levels of urinary calcium excretion were detected during ongoing treatment in comparison with 2 months check-up. There were no significant changes in the promoter/inhibitor urolithiasis parameters, oxalate, citrate, urate, cistine, glycosaminoglycans or their ratios. Urine saturation was calculated using EQUIL 2 computer programme (calcium oxalate, brushite) and it was normal. Probable trigger for the ceftriaxone/calcium hydroxy carbonate phosphate mixture of stones was a critical boost of solubility products caused by ceftriaxone treatment and phospnate urine content with a subsequent large-scale spontaneous precipitation of crystals.

Keywords: Ceftriaxone; Urolythiasis; Urine saturation; Stone promoters/inhibitors

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About the article

Published Online: 2013-04-17

Published in Print: 2013-06-01

Citation Information: Open Medicine, Volume 8, Issue 3, Pages 354–357, ISSN (Online) 2391-5463, DOI: https://doi.org/10.2478/s11536-012-0091-z.

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© 2013 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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