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Open Medicine

formerly Central European Journal of Medicine

Editor-in-Chief: Darzynkiewicz, Zbigniew


IMPACT FACTOR 2018: 1.221

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2391-5463
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Volume 8, Issue 4

Issues

Volume 10 (2015)

Therapy with acetylsalicylic acid does not interfere with oral surgery

Damian Dudek
  • Private Department of Oral Surgery and Implantology, Szosa Chełmińska Str 84, Toruń, 87-100, Poland
  • Department of Histology and Embryology, Medical University of Silesia in Katowice, Jordana Str 19, Zabrze, 41-808, Poland
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/ Krzysztof Helewski
  • Department of Histology and Embryology, Medical University of Silesia in Katowice, Jordana Str 19, Zabrze, 41-808, Poland
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/ Grzegorz Wyrobiec
  • Department of Histology and Embryology, Medical University of Silesia in Katowice, Jordana Str 19, Zabrze, 41-808, Poland
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/ Marzena Harabin-Słowińska
  • Department of Histology and Embryology, Medical University of Silesia in Katowice, Jordana Str 19, Zabrze, 41-808, Poland
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/ Grażyna Kowalczyk-Ziomek
  • Department of Histology and Embryology, Medical University of Silesia in Katowice, Jordana Str 19, Zabrze, 41-808, Poland
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/ Małgorzata Żaba
  • Department of Histology and Embryology, Medical University of Silesia in Katowice, Jordana Str 19, Zabrze, 41-808, Poland
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/ Piotr Wesołowski
  • Department of Dental Surgery, Medical University of Warsaw, Nowogrodzka Str 59, pawilon 11b, Warszawa, 02-006, Poland
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/ Tomasz Stawski / Romuald Wojnicz
  • Department of Histology and Embryology, Medical University of Silesia in Katowice, Jordana Str 19, Zabrze, 41-808, Poland
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Published Online: 2013-06-12 | DOI: https://doi.org/10.2478/s11536-013-0176-3

Abstract

The acetylsalicylic acid (ASA) treatment is widespread therapeutic strategy in cardiology clinics. On the other hand, patients with heart diseases represent a significant group of cases in dental clinics. Accordingly, we studied the local hemostatic thrombus formation after dental tooth extractions (n=47) and other oral surgery treatment (n=13) in 60 patients with heart disease being on ASA therapy without drug discontinuation. In the control group free of ASA therapy it was: (n=24) and (n=6), respectively. In all studied patients, the aggregative activity of blood platelets by PFA-100 analyzer was assessed. It was found that 61.7% patients treated with ASA presented inhibition of platelets aggregation. Unexpectedly, in 35% of such patients, platelet aggregation function remained unchanged. In the control group, normal platelet aggregation was found in all subjects. It has been shown that ASA therapy has neutral effects on both thrombus formation and pain complications in patients with heart disease underwent tooth extraction and other oral surgery. Thus discontinuation of ASA therapy before surgery seems to be weakly validated.

Keywords: Platelets; Acetylsalicylic acid; Oral surgery; Dental tooth extraction

  • [1] Kośmicki M., Kwas acetylosalicylowy i inne leki przeciwpłytkowe i przeciwkrzepliwe w leczeniu choroby niedokrwiennej serca, Przew. Lek., 2001, 10, 34–44, (in Polish) Google Scholar

  • [2] Born G., Patrono C., Antiplatelet drugs, Br. J. Pharmacol., 2006, 147, S241–S251 http://dx.doi.org/10.1038/sj.bjp.0706401CrossrefGoogle Scholar

  • [3] Patrono C., Coller B., Dalen J.E., et al., Plateletactive drugs: the relationships among dose, effectiveness, and side effects, Chest., 2001, 119, 39S–63S http://dx.doi.org/10.1378/chest.119.1_suppl.39SCrossrefGoogle Scholar

  • [4] Patrono C., Coller B., FitzGerald G.A., Hirsh J., Roth G., Platelet-active drugs: the relationships among dose, effectiveness, and side effects: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy, Chest., 2004, 126, 234S–264S http://dx.doi.org/10.1378/chest.126.3_suppl.234SCrossrefGoogle Scholar

  • [5] Hankey G.J., Eikelboom J.W., Antiplatelet drugs, Med. J. Aust., 2003, 178, 568–574 Google Scholar

  • [6] Hankey G.J., Eikelboom J.W., Aspirin for the primary prevention of cardiovascular events, Med. J. Aust., 2002, 177, 343–344 Google Scholar

  • [7] Golański R., Watała C., Bitner M., Iwaszkiewicz A., Zasłonka J., Golański J., Ocena skuteczności antyagregacyjnego działania kwasu acetylosalicylowego u chorych po bezpośredniej rewaskularyzacji mięśnia sercowego, Kardiochir. Torakochir. Pol., 2004, 1, 116–122, (in Polish) Google Scholar

  • [8] Howard P.A., Aspirin resistance, Ann. Pharmacother., 2002, 36, 1620–1624 http://dx.doi.org/10.1345/aph.1C013CrossrefGoogle Scholar

  • [9] Weber A.A., Zimmermann K.C., Meyer-Kichrath J., Schrör K., Cyclooxygenase-2 in human platelets as a possible factor in aspirin resistance, Lancet, 1999, 353, 900 http://dx.doi.org/10.1016/S0140-6736(99)00498-5CrossrefGoogle Scholar

  • [10] Halushka M.K., Halushka P.V., Why are some individuals resistant to the cardioprotective effects of aspirin? Could it be thromboxane A2?, Circulation., 2002, 105, 1620–1622 http://dx.doi.org/10.1161/01.CIR.0000015422.86569.52CrossrefGoogle Scholar

  • [11] Smout J., Stansby G., Aspirin resistance, Br. J. Surg., 2002, 89, 4–5 http://dx.doi.org/10.1046/j.0007-1323.2001.01971.xCrossrefGoogle Scholar

  • [12] Rdzanek A., Rdzanek H., Pietrasik A., Filipiak K.J., Przeciwpłytkowe działanie kwasu acetylosalicylowego — czy wszyscy pacjenci reagują tak samo?, Stand. Med., 2004, 5, 605–610, (in Polish) Google Scholar

  • [13] Golański J., Chiżyński K., Golański R., Watała C., Zastosowanie analizatora funkcji płytek PFA-100 oraz metody agregacji we krwi pełnej do oceny wrażliwości płytek krwi na działanie kwasu acetylosalicylowego (aspiryny). Czy możliwa jest wiarygodna laboratoryjna weryfikacja leczenia przeciwpłytkowego?, Pol. Arch. Med. Wewn., 2000, 104, 355–361, (in Polish) Google Scholar

  • [14] Keresztes P.A., Tazbir J., The PFA-100: analysis and interpretation of a platelet function measurement, J. Cardiovasc. Nurs., 2005, 20, 405–407 CrossrefGoogle Scholar

  • [15] Haubelt H., Anders C., Hellstern P., Can platelet function tests predict the clinical efficacy of aspirin?, Semin. Thromb. Hemost., 2005, 31, 404–410 http://dx.doi.org/10.1055/s-2005-916674CrossrefGoogle Scholar

  • [16] Coakley M., Self R., Marchant W., Mackie I., Mallett S.V., Mythen M., Use of the platelet function analyzer (PFA-100) to quantify the effect of low dose aspirin in patients with ischaemic heart disease, Anaesthesia., 2005, 60, 1173–1178 http://dx.doi.org/10.1111/j.1365-2044.2005.04291.xCrossrefGoogle Scholar

  • [17] Hayward C.P., Harrison P., Cattaneo M., Ortel T.L., Rao A.K., Platelet function analyzer PFA-100 closure time in the evaluation of platelet disorders and platelet function, J. Thromb. Haemost., 2006, 4, 312–319 http://dx.doi.org/10.1111/j.1538-7836.2006.01771.xGoogle Scholar

  • [18] Cieślik-Bielecka A., Pelc R., Cieślik T., Oral surgery procedures in patients on anticoagulants. Preeliminary report, Kardiol. Pol., 2005, 63, 137–140 Google Scholar

  • [19] Hemelik M., Wahl G., Kessler B., Zahnextraktionen unter Medikation mit Acetylsalicylsaure (ASS), Mund. Kiefer. Gesichtschir., 2006, 10, 3–6 http://dx.doi.org/10.1007/s10006-005-0666-9CrossrefGoogle Scholar

  • [20] Ardekian L., Gaspar R., Peled M., Brener B., Laufer D., Does low-dose aspirin therapy complicate oral surgical procedures?, J. Am. Dent. Assoc., 2000, 131, 331–335 Google Scholar

  • [21] Madan G.A., Madan S.G., Madan G., Madan A.D., Minor oral surgery without stopping daily low-dose aspirin therapy: a study of 51 patients, J. Oral. Maxillofac. Surg., 2005, 63, 1262–1265 http://dx.doi.org/10.1016/j.joms.2005.05.164CrossrefGoogle Scholar

  • [22] Thomason J.M., Seymour R.A., Murphy P., Brigham K.M., Jones P., Aspirin-induced post-gingivectomy haemorrhage: a timely reminder, J. Clin. Periodontol., 1997, 24, 136–138 http://dx.doi.org/10.1111/j.1600-051X.1997.tb00480.xCrossrefGoogle Scholar

  • [23] Lemkin S.R., Billesdon J.E., Davee J.S., Leake D.L., Kattlove H.E., Aspirin induced oral bleeding: correction with platelet transfusion. A reminder, Oral. Surg. Oral Med. Oral Pathol., 1974, 37, 498–501 http://dx.doi.org/10.1016/0030-4220(74)90278-3CrossrefGoogle Scholar

  • [24] McGaul T., Postoperative bleeding caused by aspirin, J. Dent., 1978, 6, 207–209 http://dx.doi.org/10.1016/0300-5712(78)90243-9CrossrefGoogle Scholar

  • [25] Mak S., Amoroso P., Stop those antiplatelet drugs before surgery!, BJU. Int., 2003, 91, 593–594 http://dx.doi.org/10.1046/j.1464-410X.2003.04209.xCrossrefGoogle Scholar

  • [26] Richardson J.D., Cocanour C.S., Kern J.A., et al., Perioperative risk assessment in elderly and high-risk patients, J. Am. Coll. Surg., 2004, 199, 133–146 http://dx.doi.org/10.1016/j.jamcollsurg.2004.02.023CrossrefGoogle Scholar

  • [27] Bochenek A., Wilczyński M., Leki przeciwpłytkowe — krwawiący problem kardiochirurga, Kardiol. Pol., 2006, 64, 1329–1331, (in Polish) Google Scholar

  • [28] Bybee K.A., Powell B.D., Valeti U., et al., Preoperative aspirin therapy is associated with improved postoperative outcomes in patients undergoing coronary artery bypass grafting, Circulation., 2005, 112, I-286–292 Google Scholar

  • [29] Samama C.M., Bastien O., Forestier F., et al., Antiplatelet agents in the perioperative period: expert recommendations of the French Society of Anesthesiology and Intensive Care (SFAR) 2001: summary statement, Can. J. Anaesth., 2002, 49, S26–S35 Google Scholar

  • [30] Lewandowski B., Maresch-Lewandowska M., Surgicell-fibrillar in the prevention of post extraction bleeding in patients receiving prophylactic aspirin, Mag. Stomatol., 2005, 1, 20–23, (in Polish) Google Scholar

About the article

Published Online: 2013-06-12

Published in Print: 2013-08-01


Citation Information: Open Medicine, Volume 8, Issue 4, Pages 392–397, ISSN (Online) 2391-5463, DOI: https://doi.org/10.2478/s11536-013-0176-3.

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© 2013 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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