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Open Medicine

formerly Central European Journal of Medicine

Editor-in-Chief: Darzynkiewicz, Zbigniew

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IMPACT FACTOR 2016 (Open Medicine): 0.294
IMPACT FACTOR 2016 (Central European Journal of Medicine): 0.116

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2391-5463
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Volume 8, Issue 4

Issues

Volume 10 (2015)

Neurophysiological evaluation in newly diagnosed Diabetes Mellitus type 1

Dragana Matanovic
  • Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Clinic for Physical Medicine and Rehabilitation, Clinical Center of Serbia, Belgrade, Serbia
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Srdjan Popovic
  • Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Clinic of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Belgrade, Serbia
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Biljana Parapid / Ivana Petronic
  • Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Physical Medicine and Rehabilitation Department, University Children’s Hospital, Belgrade, Serbia
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Dejan Nikolic
Published Online: 2013-06-12 | DOI: https://doi.org/10.2478/s11536-013-0181-6

Abstract

The aim of the study was to evaluate the effects of hyperglycemia on nerve conduction in patients with newly diagnosed diabetes mellitus type 1, and to investigate the significance of early electrophysiological diagnostics in these patients. The study included 85 newly disclosed patients with type 1 diabetes mellitus, in the first three months after the disease. Nerve conduction velocities (NCV) of further nerves were evaluated: median, peroneal, tibial and sural nerve as well as late responses (F-wave and H-reflex). Metabolic control parameters that were evaluated included: glycemia rate on the day of investigation and HbA1c. All patients had poor metabolic control parameters. We found NCV slowing predominantly in the tibial nerve (in 82.4% of patients). Prolonged F-wave latency was disclosed in 72.9% of patients, while H-reflex was evoked in 27.1% of patients only. The most sensitive parameter in the early neurophysiologic diagnostics was the measurement of F-wave latency. Our study underline the significance of early neurophysiological diagnosis, since hyperglycemia can play an acute role in NCV slowing, despite the absence of clinical symptoms, particularly in the first three months after the diagnosis has been confirmed.

Keywords: Neurophysiologic parameters; Nerve Conduction Velocity; Diabetes Mellitus; Polyneuropathy

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About the article

Published Online: 2013-06-12

Published in Print: 2013-08-01


Citation Information: Open Medicine, Volume 8, Issue 4, Pages 503–508, ISSN (Online) 2391-5463, DOI: https://doi.org/10.2478/s11536-013-0181-6.

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© 2013 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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